The JAK-STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms.
Atherosclerosis
Baricitinib
Cardiovascular disease
Inflammation
JAK–STAT pathway
Myeloproliferative neoplasm
Rheumatoid arthritis
Ruxolitinib
Tofacitinib
Journal
European heart journal
ISSN: 1522-9645
Titre abrégé: Eur Heart J
Pays: England
ID NLM: 8006263
Informations de publication
Date de publication:
07 11 2021
07 11 2021
Historique:
received:
10
04
2021
revised:
21
05
2021
accepted:
31
07
2021
pubmed:
4
8
2021
medline:
18
11
2021
entrez:
3
8
2021
Statut:
ppublish
Résumé
Inflammation contributes centrally to cardiovascular diseases, and anti-inflammatory treatments can reduce cardiovascular events. The JAK-STAT pathway is an emerging target in inflammation, mainly in rheumatoid arthritis (RA) and chronic myeloproliferative neoplasms (MPNs), disorders that heighten cardiovascular risk. The aim of this study was to review the international literature on the relationship between dysregulation of the JAK-STAT pathway in RA/MPNs and cardiovascular risk and on the potential cardiovascular effects of JAK-STAT inhibitors. The JAK-STAT pathway sustains inflammatory and thrombotic events in autoimmune disorders such as RA and MPNs. Here, an imbalance exists between pro- and anti-inflammatory cytokines [increased levels of interleukin (IL)-6, IL-1-β, tumour necrosis factor-α, decreased levels of IL-10] and the over-expression of some prothrombotic proteins, such as protein kinase Cε, on the surface of activated platelets. This pathway also operates in atherosclerotic cardiovascular disease. JAK-STAT inhibitors may reduce cardiovascular events and related deaths in such conditions, but the potential of these agents requires more studies, especially with regard to cardiovascular safety, and particularly for potential prothrombotic effects. JAK-STAT inhibitors merit consideration to curb heightened cardiovascular risk in patients with RA and MPNs, with rigorous assessment of the potential benefits and risks.
Identifiants
pubmed: 34343257
pii: 6338052
doi: 10.1093/eurheartj/ehab447
pmc: PMC8572559
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4389-4400Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL134892
Pays : United States
Informations de copyright
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.
Références
Cancer J. 2007 Nov-Dec;13(6):366-71
pubmed: 18032973
Nat Rev Endocrinol. 2017 Apr;13(4):220-231
pubmed: 27716751
Blood. 2012 Dec 13;120(25):4921-8
pubmed: 23043069
Curr Rheumatol Rep. 2021 Jan 28;23(2):9
pubmed: 33511473
Am J Nurs. 2019 Nov;119(11):20
pubmed: 31651491
Am Heart J. 2019 Sep;215:62-69
pubmed: 31284074
JAMA. 2021 Mar 16;325(11):1043-1044
pubmed: 33616637
Blood. 2014 May 1;123(18):2768-76
pubmed: 24366358
J Intern Med. 2014 Dec;276(6):618-32
pubmed: 25156650
Heart Vessels. 2016 Oct;31(10):1714-6
pubmed: 26825737
Nature. 2005 Apr 28;434(7037):1144-8
pubmed: 15793561
Cell Metab. 2017 Jul 5;26(1):71-93
pubmed: 28683296
Arthritis Rheumatol. 2019 Sep;71(9):1450-1459
pubmed: 31385441
Am Heart J. 2019 Dec;218:46-56
pubmed: 31706144
Thromb Haemost. 2015 May;113(5):916-30
pubmed: 25716931
Eur J Clin Invest. 2005 Feb;35(2):93-8
pubmed: 15667579
Am J Hematol. 2015 Feb;90(2):109-13
pubmed: 25352381
Eur Heart J. 2010 Jun;31(12):1457-69
pubmed: 20447947
Curr Atheroscler Rep. 2019 Jan 25;21(2):7
pubmed: 30684090
Leukemia. 2016 Aug;30(8):1701-7
pubmed: 27211272
Oncotarget. 2016 Nov 1;7(44):72311-72321
pubmed: 27527867
Blood. 2013 Mar 7;121(10):1701-11
pubmed: 23335367
Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):288-95
pubmed: 25147339
Nature. 2000 Jan 13;403(6766):207-11
pubmed: 10646607
Arthritis Rheum. 2008 Dec 15;59(12):1690-7
pubmed: 19035419
Circulation. 2003 Feb 18;107(6):798-802
pubmed: 12591746
Wien Klin Wochenschr. 2021 Jan 19;:
pubmed: 33464403
Mol Cell Endocrinol. 2017 Aug 15;451:71-79
pubmed: 28167129
J Mol Cell Cardiol. 2002 Nov;34(11):1443-53
pubmed: 12431443
Nat Rev Cardiol. 2020 Jun;17(6):327-340
pubmed: 31996800
Drug Saf. 2020 Sep;43(9):881-891
pubmed: 32533433
Cold Spring Harb Perspect Med. 2020 Feb 3;10(2):
pubmed: 31548225
N Engl J Med. 2019 Dec 26;381(26):2497-2505
pubmed: 31733140
Circ Res. 2018 Jun 8;122(12):1722-1740
pubmed: 29880500
Eur Heart J. 2015 Feb 21;36(8):482-9c
pubmed: 25433021
Haematologica. 2008 Mar;93(3):372-80
pubmed: 18268279
J Geriatr Cardiol. 2017 Feb;14(2):135-150
pubmed: 28491088
Int J Mol Sci. 2019 Mar 30;20(7):
pubmed: 30935055
Front Med (Lausanne). 2021 Feb 05;7:607725
pubmed: 33614673
N Engl J Med. 2004 Oct 21;351(17):1709-11
pubmed: 15470192
Z Rheumatol. 2020 Apr;79(3):232-240
pubmed: 32206866
Blood. 2009 Mar 26;113(13):2895-901
pubmed: 18988864
Front Oncol. 2020 Oct 07;10:579221
pubmed: 33117717
Sci Transl Med. 2018 Apr 11;10(436):
pubmed: 29643232
Rheum Dis Clin North Am. 2010 May;36(2):405-26
pubmed: 20510241
Blood. 2013 Nov 28;122(23):3787-97
pubmed: 24085768
J Am Coll Cardiol. 2016 Feb 16;67(6):712-723
pubmed: 26868696
Clin Exp Rheumatol. 2008 Jul-Aug;26(4):673-9
pubmed: 18799105
Arthritis Rheumatol. 2019 Jul;71(7):1042-1055
pubmed: 30663869
N Engl J Med. 2008 Nov 20;359(21):2195-207
pubmed: 18997196
Arthritis Rheumatol. 2020 Jan;72(1):31-40
pubmed: 31469238
Drugs. 2017 Apr;77(5):521-546
pubmed: 28255960
Exp Hematol. 2007 May;35(5):702-11
pubmed: 17577920
Curr Hematol Malig Rep. 2021 Jun;16(3):304-313
pubmed: 33876389
Rheumatol Int. 2017 Dec;37(12):2079-2085
pubmed: 29030660
J Exp Med. 2020 May 4;217(5):
pubmed: 32267936
N Engl J Med. 2013 May 23;368(21):2004-13
pubmed: 23697515
Circ Res. 2020 Apr 24;126(9):1228-1241
pubmed: 32324499
J Hematol Oncol. 2017 Feb 22;10(1):55
pubmed: 28228106
Haematologica. 2020 Aug;105(8):2020-2031
pubmed: 32554558
Cleve Clin J Med. 2021 Feb 1;:
pubmed: 33526440
Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1579-88
pubmed: 25953648
Cancer J. 2014 Jan-Feb;20(1):61-5
pubmed: 24445766
Am Heart J. 2011 Oct;162(4):597-605
pubmed: 21982649
Mol Diagn Ther. 2012 Oct;16(5):269-83
pubmed: 23023734
Cardiovasc Res. 2019 Jul 1;115(8):1266-1285
pubmed: 30918936
Ann Intern Med. 2018 Mar 6;168(5):317-325
pubmed: 29335713
Biomolecules. 2020 Jul 05;10(7):
pubmed: 32635659
J Am Coll Cardiol. 2021 Apr 20;77(15):1856-1858
pubmed: 33858621
Cytokine. 2021 Aug;144:155549
pubmed: 33962843
Ann Pharmacother. 2019 Sep;53(9):947-953
pubmed: 30907116
Biochem Pharmacol. 2006 Mar 14;71(6):713-21
pubmed: 16426581
Cells. 2021 Apr 20;10(4):
pubmed: 33924019
Int J Cardiol. 2015 Mar 1;182:48-9
pubmed: 25585370
BMC Cancer. 2018 Apr 13;18(1):420
pubmed: 29653557
Arthritis Rheum. 2001 Dec;44(12):2737-45
pubmed: 11762933
Case Rep Hematol. 2015;2015:161764
pubmed: 26064712
Hematol Oncol. 2020 Apr;38(2):121-128
pubmed: 31833567
Circ Res. 2020 Apr 24;126(9):1260-1280
pubmed: 32324502
Circulation. 2005 Mar 22;111(11):1355-61
pubmed: 15753219
Drugs. 2019 Nov;79(16):1819-1828
pubmed: 31642025
Leukemia. 2013 Aug;27(8):1617-20
pubmed: 23558521
Blood Rev. 2020 Jul;42:100711
pubmed: 32505517
Drugs. 2019 Jun;79(8):887-891
pubmed: 31093950
Nature. 2021 Apr;592(7853):296-301
pubmed: 33731931
Circ Res. 2020 Apr 24;126(9):1112-1126
pubmed: 32324494
Nat Immunol. 2017 Mar 22;18(4):374-384
pubmed: 28323260
J Thromb Haemost. 2020 Apr;18(4):916-925
pubmed: 32017387
J Clin Med. 2020 Jul 08;9(7):
pubmed: 32650513
JAKSTAT. 2012 Apr 1;1(2):118-24
pubmed: 24058760
J Hematol Oncol. 2017 Sep 29;10(1):156
pubmed: 28962635
Blood. 2011 Jun 2;117(22):5857-9
pubmed: 21490340
Blood. 2007 Jul 1;110(1):354-9
pubmed: 17376889
J Mol Cell Cardiol. 2011 Apr;50(4):589-97
pubmed: 21223971
Eur Heart J. 2021 Jan 1;42(1):113-131
pubmed: 32176778
J Biol Chem. 2008 Feb 29;283(9):5258-66
pubmed: 18158285
Trends Immunol. 2019 Jul;40(7):648-664
pubmed: 31155315
Thromb Haemost. 2016 Jan;115(1):73-80
pubmed: 26489695
J Gen Intern Med. 2021 Aug;36(8):2517-2518
pubmed: 32705476
Ann Rheum Dis. 2017 Nov;76(11):1949-1952
pubmed: 28916714
Thromb Haemost. 2016 Nov 30;116(6):1012-1021
pubmed: 27535617
Lancet. 2017 Jun 10;389(10086):2328-2337
pubmed: 28612747
Cytokine Growth Factor Rev. 2015 Dec;26(6):673-85
pubmed: 26005197
Atherosclerosis. 2013 Jul;229(1):174-81
pubmed: 23746537
J Clin Oncol. 2005 Apr 1;23(10):2224-32
pubmed: 15710945
J Clin Invest. 2010 Sep;120(9):3280-95
pubmed: 20697158
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
Curr Opin Lipidol. 2016 Oct;27(5):473-83
pubmed: 27472409
Circ Res. 2018 May 25;122(11):1488-1490
pubmed: 29798896
Eur Heart J. 2016 Aug 07;37(30):2406-13
pubmed: 27161611
Am J Physiol Cell Physiol. 2004 Sep;287(3):C771-80
pubmed: 15151905
Chem Biol. 2006 Nov;13(11):1235-42
pubmed: 17114005
Semin Arthritis Rheum. 2016 Dec;46(3):261-271
pubmed: 27443588
Ann Transl Med. 2017 Jul;5(13):273
pubmed: 28758099
Ann Rheum Dis. 2017 Aug;76(8):1396-1404
pubmed: 28219882
Rheumatol Int. 2020 Aug;40(8):1181-1191
pubmed: 32524301
Ann Rheum Dis. 2019 Aug;78(8):1048-1054
pubmed: 31088790
Trials. 2021 Feb 5;22(1):116
pubmed: 33546739
Biochem Biophys Rep. 2020 Nov 02;24:100838
pubmed: 33195828
Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15818-15826
pubmed: 32541024
N Engl J Med. 2017 Jul 13;377(2):111-121
pubmed: 28636844
Sci STKE. 2004 Nov 23;2004(260):tr8
pubmed: 15561980
Blood. 2010 Jan 28;115(4):778-82
pubmed: 19965680
Autoimmun Rev. 2019 Nov;18(11):102390
pubmed: 31520803
Circ Res. 2019 Jan 4;124(1):150-160
pubmed: 30605419
Arthritis Rheumatol. 2015 Mar;67(3):616-25
pubmed: 25470338
Int J Cardiol. 2013 Oct 15;168(6):5126-34
pubmed: 23978367
J Hematol Oncol. 2020 Dec 2;13(1):162
pubmed: 33267911
Clin Exp Rheumatol. 2021 Jan 6;:
pubmed: 33427624
N Engl J Med. 2019 Feb 21;380(8):752-762
pubmed: 30415610
Blood Coagul Fibrinolysis. 2016 Sep;27(6):648-52
pubmed: 26569516
Mayo Clin Proc. 2020 Jul;95(7):1404-1419
pubmed: 32499126
BMC Public Health. 2021 Feb 25;21(1):401
pubmed: 33632204
BMJ. 2018 Apr 23;361:k1036
pubmed: 29685876
Nat Rev Rheumatol. 2013 Sep;9(9):513-23
pubmed: 23774906
Ther Adv Musculoskelet Dis. 2018 Jun;10(5-6):117-127
pubmed: 29942363
Nat Rev Dis Primers. 2019 Aug 16;5(1):56
pubmed: 31420554
Joint Bone Spine. 2020 Mar;87(2):119-129
pubmed: 31521793
Int J Mol Sci. 2017 Feb 24;18(3):
pubmed: 28245561
Haematologica. 2006 Feb;91(2):169-75
pubmed: 16461300
Front Cardiovasc Med. 2020 May 05;7:53
pubmed: 32478094
Clin Lymphoma Myeloma Leuk. 2018 Jan;18(1):1-12
pubmed: 29277359
Int J Cardiol. 2018 May 15;259:213-215
pubmed: 29579604
JAMA. 2016 Apr 19;315(15):1591-9
pubmed: 27043082
Cells. 2020 Dec 24;10(1):
pubmed: 33374145
Front Med (Lausanne). 2020 May 05;7:124
pubmed: 32432116
Clin Rev Allergy Immunol. 2020 Dec;59(3):334-351
pubmed: 32222877
Ann Rheum Dis. 2020 Jun;79(6):685-699
pubmed: 31969328
Rheumatology (Oxford). 2019 Feb 1;58(Suppl 1):i43-i54
pubmed: 30806709
Expert Rev Hematol. 2020 Oct;13(10):1067-1072
pubmed: 32873088
Eur Heart J. 2017 Jun 7;38(22):1702-1704
pubmed: 30052884
Immunol Res. 2013 Jul;56(2-3):267-86
pubmed: 23584985
Haematologica. 2016 Jul;101(7):821-9
pubmed: 27102499
Blood Adv. 2020 Jan 28;4(2):380-386
pubmed: 31985808
J Immunol. 2016 Jan 15;196(2):596-606
pubmed: 26667168
Blood Res. 2021 Apr 30;56(S1):S26-S33
pubmed: 33935032
Circ Res. 2009 Jan 30;104(2):e9-18
pubmed: 19096025
Curr Cancer Drug Targets. 2011 Jan;11(1):20-30
pubmed: 21062246
Leukemia. 2008 Oct;22(10):1813-7
pubmed: 18754026
Rheumatology (Oxford). 2019 Feb 1;58(Suppl 1):i17-i26
pubmed: 30806707
Blood. 2013 Nov 28;122(23):3705-6
pubmed: 24288407
Arch Cardiovasc Dis. 2010 Apr;103(4):253-61
pubmed: 20656636
N Engl J Med. 2010 Jul 22;363(4):396-7
pubmed: 20660412
Lancet. 2012 Mar 31;379(9822):1205-13
pubmed: 22421339
Thrombosis. 2011;2011:794240
pubmed: 22084668
BMC Rheumatol. 2018 Apr 11;2:10
pubmed: 30886961
Leukemia. 2007 Sep;21(9):1952-9
pubmed: 17625606
J Am Coll Cardiol. 2013 Jan 29;61(4):404-410
pubmed: 23265346
Clin Exp Rheumatol. 2020 Nov-Dec;38(6):1201-1205
pubmed: 32452351
Clin Ther. 2014 Jul 1;36(7):1074-86
pubmed: 25047498
J Clin Invest. 2018 Oct 1;128(10):4359-4371
pubmed: 30024857
Clin Lymphoma Myeloma Leuk. 2015 Apr;15(4):214-221.e1
pubmed: 25682576
Rheumatology (Oxford). 2020 Mar 1;59(3):505-512
pubmed: 31504942
Br J Haematol. 2020 Dec;191(5):764-774
pubmed: 32583458
Br J Haematol. 2003 Apr;121(1):76-85
pubmed: 12670334
N Engl J Med. 2005 Apr 28;352(17):1779-90
pubmed: 15858187