Cyclic growth of dermal papilla and regeneration of follicular mesenchymal components during feather cycling.
Animals
Cell Differentiation
/ physiology
Cell Proliferation
/ physiology
Chickens
/ physiology
Dermis
/ physiology
Epidermal Cells
/ physiology
Feathers
/ physiology
Hair
/ physiology
Hair Follicle
/ physiology
Molting
/ physiology
Regeneration
/ physiology
Signal Transduction
/ physiology
Stem Cells
/ physiology
Chicken
Dermis
Evo-Devo
Evolution
Follicle
Morphogenesis
Stem cell niche
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
15 09 2021
15 09 2021
Historique:
received:
15
11
2020
accepted:
08
07
2021
entrez:
3
8
2021
pubmed:
4
8
2021
medline:
9
11
2021
Statut:
ppublish
Résumé
How dermis maintains tissue homeostasis in cyclic growth and wounding is a fundamental unsolved question. Here, we study how dermal components of feather follicles undergo physiological (molting) and plucking injury-induced regeneration in chickens. Proliferation analyses reveal quiescent, transient-amplifying (TA) and long-term label-retaining dermal cell (LRDC) states. During the growth phase, LRDCs are activated to make new dermal components with distinct cellular flows. Dermal TA cells, enriched in the proximal follicle, generate both peripheral pulp, which extends distally to expand the epithelial-mesenchymal interactive interface for barb patterning, and central pulp, which provides nutrition. Entering the resting phase, LRDCs, accompanying collar bulge epidermal label-retaining cells, descend to the apical dermal papilla. In the next cycle, these apical dermal papilla LRDCs are re-activated to become new pulp progenitor TA cells. In the growth phase, lower dermal sheath can generate dermal papilla and pulp. Transcriptome analyses identify marker genes and highlight molecular signaling associated with dermal specification. We compare the cyclic topological changes with those of the hair follicle, a convergently evolved follicle configuration. This work presents a model for analyzing homeostasis and tissue remodeling of mesenchymal progenitors.
Identifiants
pubmed: 34344024
pii: 271168
doi: 10.1242/dev.198671
pmc: PMC10656464
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK048522
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR047364
Pays : United States
Organisme : NIAMS NIH HHS
ID : R37 AR060306
Pays : United States
Informations de copyright
© 2021. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing or financial interests.
Références
Nat Protoc. 2016 Sep;11(9):1650-67
pubmed: 27560171
Sci Rep. 2018 Nov 13;8(1):16766
pubmed: 30425309
Cell. 2019 Nov 27;179(6):1409-1423.e17
pubmed: 31778655
Exp Dermatol. 2017 Jun;26(6):505-509
pubmed: 28418596
Annu Rev Anim Biosci. 2015;3:169-95
pubmed: 25387232
Nature. 2005 Dec 15;438(7070):1026-9
pubmed: 16355227
Am J Pathol. 1991 Feb;138(2):427-40
pubmed: 1704192
Stem Cell Reports. 2018 May 8;10(5):1432-1438
pubmed: 29742389
Dev Biol. 2018 May 15;437(2):63-74
pubmed: 29544769
Physiology (Bethesda). 2012 Apr;27(2):61-72
pubmed: 22505663
Dev Cell. 2014 Dec 8;31(5):543-58
pubmed: 25465495
J Invest Dermatol. 1999 Dec;113(6):873-7
pubmed: 10594724
Curr Opin Genet Dev. 2012 Oct;22(5):485-93
pubmed: 23084810
J Invest Dermatol. 2010 May;130(5):1202-4
pubmed: 20393474
Dev Cell. 2017 Nov 20;43(4):387-401
pubmed: 29161590
NPJ Regen Med. 2017 Apr 14;2:11
pubmed: 29302347
Cold Spring Harb Perspect Med. 2014 Jul 01;4(7):a015180
pubmed: 24985131
Science. 2016 Dec 23;354(6319):1533-1534
pubmed: 28008029
Dev Biol. 2014 Mar 15;387(2):167-78
pubmed: 24463139
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):951-5
pubmed: 16418297
Cell. 2017 Apr 20;169(3):483-496.e13
pubmed: 28413068
Genome Biol. 2014;15(12):550
pubmed: 25516281
Dev Biol. 2012 Dec 1;372(1):45-54
pubmed: 23000358
Development. 2013 Apr;140(8):1676-83
pubmed: 23487317
J Invest Dermatol. 2012 Dec;132(12):2681-90
pubmed: 22763785
Dev Cell. 2020 Apr 20;53(2):185-198.e7
pubmed: 32315612
J Invest Dermatol. 2003 Jun;120(6):895-904
pubmed: 12787113
J Tissue Eng Regen Med. 2019 Sep;13(9):1738-1755
pubmed: 31216380
Nat Biotechnol. 2015 Mar;33(3):290-5
pubmed: 25690850
Nat Rev Mol Cell Biol. 2011 Feb;12(2):126-31
pubmed: 21253000
J Morphol. 2009 Oct;270(10):1166-208
pubmed: 19396862
Nat Commun. 2017 Jan 20;8:ncomms14139
pubmed: 28106042
Science. 2014 Dec 12;346(6215):1253293
pubmed: 25504729
J Invest Dermatol. 2004 Jun;122(6):1348-55
pubmed: 15175023
J Invest Dermatol. 2010 Nov;130(11):2664-6
pubmed: 20574444
Development. 1992 Nov;116(3):563-71
pubmed: 1289054
Dev Growth Differ. 2019 Jan;61(1):124-138
pubmed: 30569461
Wiley Interdiscip Rev Dev Biol. 2013 Jan-Feb;2(1):97-112
pubmed: 23539312
Dev Cell. 2019 Jan 7;48(1):17-31.e6
pubmed: 30595533
Int J Dev Biol. 2004;48(2-3):181-91
pubmed: 15272383
J Cell Sci. 2008 May 1;121(Pt 9):1435-43
pubmed: 18398001
J Exp Zool B Mol Dev Evol. 2003 Aug 15;298(1):42-56
pubmed: 12949768
J Invest Dermatol. 2003 Dec;121(6):1267-75
pubmed: 14675169
Exp Dermatol. 2019 Apr;28(4):419-424
pubmed: 30919474
Science. 2013 Jun 21;340(6139):1442-5
pubmed: 23618762