Do biologic therapies reduce aortic inflammation in rheumatoid arthritis patients?
Aortic inflammation
Biologic therapy
FDG PET/CT
Rheumatoid arthritis
Journal
Arthritis research & therapy
ISSN: 1478-6362
Titre abrégé: Arthritis Res Ther
Pays: England
ID NLM: 101154438
Informations de publication
Date de publication:
03 08 2021
03 08 2021
Historique:
received:
13
05
2021
accepted:
14
07
2021
entrez:
4
8
2021
pubmed:
5
8
2021
medline:
14
8
2021
Statut:
epublish
Résumé
Rheumatoid arthritis (RA) patients have an increased risk of cardiovascular disease (CVD). In the present study, we evaluated the inflammatory activity of the ascending aorta in RA patients who received biological treatment. We assessed the aortic wall inflammation of RA patients using A total of 64 patients were included in the analysis (mean age, 58.4 ± 13.8 years old; female, 77%). The Disease Activity Score for 28 joints (DAS28) erythrocyte sedimentation rate (ESR) had significantly decreased after 6 months: from 5.0 ± 1.2 to 3.3 ± 1.2 (p < 0.001). The FDG uptake in the ascending aorta changed from baseline to 6 months, showing a maximum SUV (SUV The inflammation activity at the ascending aorta in RA patients did not change significantly after 6 months of biological treatment. RA patients with a low disease activity or in clinical remission after 6 months of biological treatment still had an increased inflammatory activity at the aortic wall.
Identifiants
pubmed: 34344436
doi: 10.1186/s13075-021-02585-w
pii: 10.1186/s13075-021-02585-w
pmc: PMC8330127
doi:
Substances chimiques
Radiopharmaceuticals
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
206Informations de copyright
© 2021. The Author(s).
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