Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis.
Journal
NPJ Regenerative medicine
ISSN: 2057-3995
Titre abrégé: NPJ Regen Med
Pays: United States
ID NLM: 101699846
Informations de publication
Date de publication:
03 Aug 2021
03 Aug 2021
Historique:
received:
04
08
2020
accepted:
07
07
2021
entrez:
4
8
2021
pubmed:
5
8
2021
medline:
5
8
2021
Statut:
epublish
Résumé
Tissue repair after lesion usually leads to scar healing and thus loss of function in adult mammals. In contrast, other adult vertebrates such as amphibians have the ability to regenerate and restore tissue homeostasis after lesion. Understanding the control of the repair outcome is thus a concerning challenge for regenerative medicine. We recently developed a model of induced tissue regeneration in adult mice allowing the comparison of the early steps of regenerative and scar healing processes. By using studies of gain and loss of function, specific cell depletion approaches, and hematopoietic chimeras we demonstrate here that tissue regeneration in adult mammals depends on an early and transient peak of granulocyte producing reactive oxygen species and an efficient efferocytosis specifically by tissue-resident macrophages. These findings highlight key and early cellular pathways able to drive tissue repair towards regeneration in adult mammals.
Identifiants
pubmed: 34344890
doi: 10.1038/s41536-021-00151-1
pii: 10.1038/s41536-021-00151-1
pmc: PMC8333253
doi:
Types de publication
Journal Article
Langues
eng
Pagination
41Subventions
Organisme : Fondation pour la Recherche Médicale (Foundation for Medical Research in France)
ID : FDT201904008033
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR 16-CE14-0006-01
Informations de copyright
© 2021. The Author(s).
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