Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 08 2021
03 08 2021
Historique:
received:
01
04
2021
accepted:
06
07
2021
entrez:
4
8
2021
pubmed:
5
8
2021
medline:
10
11
2021
Statut:
epublish
Résumé
The aim of this study was to investigate central pain representations during loading of the periodontium induced by orthodontic and occlusal stress. Nineteen healthy male volunteers (25.7 ± 2.8 years) were tested on two consecutive days: after phenotyping (questionnaires) and determination of warmth (WPT) and heat (HPT) pain thresholds, functional magnetic resonance imaging was performed as event-related paradigm including 36 tooth clenchings of 3 s duration, alternating with rest periods varying between 20-30 s. The task was performed in absence (T1) and 24 h after placement of an elastic separator between the second bicuspid and the first molar on the right side of the lower jaw (T2). No significant changes in WPT and HPT were observed but pain ratings were significantly elevated at T2. Significantly elevated activation at T2, as compared to T1, was found in bilateral sensorimotor cortex, bilateral secondary sensory cortex, supplementary motor area, right rolandic operculum, and bilateral insula. Our data show for the first time in humans that periodontal stimulation, as tested by tooth clenching in the presence of an elastic separator, goes along with specific expressions of pain at behavioral and neuronal network levels. Findings supplement the existing neuroimaging literature on odontogenic pain.
Identifiants
pubmed: 34344918
doi: 10.1038/s41598-021-94775-4
pii: 10.1038/s41598-021-94775-4
pmc: PMC8333250
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15738Informations de copyright
© 2021. The Author(s).
Références
Arch Gen Psychiatry. 1961 Jun;4:561-71
pubmed: 13688369
J Oral Rehabil. 2020 Aug;47(8):1052-1064
pubmed: 32415993
Neuroscience. 2018 Sep 1;387:58-71
pubmed: 28978414
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Neurosci Bull. 2012 Apr;28(2):131-44
pubmed: 22466124
J Clin Periodontol. 2012 May;39(5):441-7
pubmed: 22417324
Eur J Neurosci. 2005 Jun;21(11):3133-42
pubmed: 15978022
J Dent Res. 2004 Oct;83(10):757-61
pubmed: 15381714
Pain. 2005 Dec 5;118(3):390-399
pubmed: 16289801
Clin Oral Investig. 2020 Jun;24(6):2005-2013
pubmed: 31520181
Brain Struct Funct. 2010 Jun;214(5-6):655-67
pubmed: 20512370
Am J Orthod Dentofacial Orthop. 1989 Jul;96(1):47-53
pubmed: 2750720
Periodontol 2000. 2014 Feb;64(1):57-80
pubmed: 24320956
Open Dent J. 2018 Jul 31;12:520-528
pubmed: 30197691
J Oral Facial Pain Headache. 2015 Fall;29(4):349-62
pubmed: 26485382
Neurosci Biobehav Rev. 2000 Jun;24(4):485-501
pubmed: 10817845
Eur J Orthod. 1996 Aug;18(4):349-57
pubmed: 8921656
Hum Brain Mapp. 2013 Jan;34(1):109-49
pubmed: 22131304
Pain. 1975 Sep;1(3):277-299
pubmed: 1235985
J Dent Res. 2012 Feb;91(2):156-60
pubmed: 22157099
Saudi Dent J. 2011 Apr;23(2):55-9
pubmed: 24151415
Front Neurosci. 2013 Feb 05;6:197
pubmed: 23386806
Eur J Orthod. 1999 Aug;21(4):387-96
pubmed: 10502901
J Transl Med. 2020 Jan 13;18(1):22
pubmed: 31931814
J Orofac Orthop. 2013 Sep;74(5):420-34
pubmed: 23974442
Oral Maxillofac Surg Clin North Am. 2008 May;20(2):133-44, v
pubmed: 18343320
Pain. 1992 Mar;48(3):413-420
pubmed: 1594265
Br J Addict. 1991 Sep;86(9):1119-27
pubmed: 1932883
Clin Oral Investig. 2014 Nov;18(8):1949-61
pubmed: 24420503
J Physiol. 1993 May;464:393-405
pubmed: 8229809
Neuroimage. 2007 Jul 1;36(3):511-21
pubmed: 17499520
Eur J Orthod. 1999 Jun;21(3):231-47
pubmed: 10407533
Eur J Oral Sci. 2009 Feb;117(1):27-33
pubmed: 19196315
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491
Cochrane Database Syst Rev. 2017 Nov 28;11:CD003976
pubmed: 29182798
J Pain Res. 2016 Sep 15;9:671-681
pubmed: 27695361
J Orofac Pain. 2013 Summer;27(3):206-16
pubmed: 23882453
Neuroimage. 2005 Jul 1;26(3):839-51
pubmed: 15955494
Prog Mol Biol Transl Sci. 2015;131:251-79
pubmed: 25744676
J Dent Res. 2014 Feb;93(2):126-33
pubmed: 24221915