Transcriptomic analyses of livers from mice exposed to 1,4-dioxane for up to 90 days to assess potential mode(s) of action underlying liver tumor development.
1,4-Dioxane
Hepatotoxicity
Mechanisms
Mode of action
Transcriptomics
Journal
Current research in toxicology
ISSN: 2666-027X
Titre abrégé: Curr Res Toxicol
Pays: Netherlands
ID NLM: 101771915
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
10
2020
revised:
06
01
2021
accepted:
07
01
2021
entrez:
4
8
2021
pubmed:
5
8
2021
medline:
5
8
2021
Statut:
epublish
Résumé
1,4-Dioxane is a volatile organic compound with industrial and commercial applications as a solvent and in the manufacture of other chemicals. 1,4-Dioxane has been demonstrated to induce liver tumors in chronic rodent bioassays conducted at very high doses. The available evidence for 1,4-dioxane-induced liver tumors in rodents aligns with a threshold-dependent mode of action (MOA), with the underlying mechanism being less clear in the mouse than in rats. To gain a better understanding of the underlying molecular mechanisms related to liver tumor development in mice orally exposed to 1,4-dioxane, transcriptomics analysis was conducted on liver tissue collected from a 90-day drinking water study in female B6D2F
Identifiants
pubmed: 34345848
doi: 10.1016/j.crtox.2021.01.003
pii: S2666-027X(21)00003-7
pmc: PMC8320614
doi:
Types de publication
Journal Article
Langues
eng
Pagination
30-41Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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