Effect of a nutritional supplementation on growth and body composition in short and lean preadolescent boys: A randomised, double-blind, placebo-controlled study.
body composition
linear growth
nutritional supplementation
preadolescents
short stature
Journal
Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Titre abrégé: Acta Paediatr
Pays: Norway
ID NLM: 9205968
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
revised:
01
08
2021
received:
24
02
2021
accepted:
02
08
2021
pubmed:
5
8
2021
medline:
28
1
2022
entrez:
4
8
2021
Statut:
ppublish
Résumé
To evaluate the effect of nutritional supplementation on height, weight and body composition in short and lean male preadolescents. A randomised, double-blinded, placebo-controlled trial of nutritional supplementation of short and lean prepubertal 10-14.5-year-old boys. Primary outcomes included Δheight-SDS and Δweight-SDS. Secondary outcomes included changes in body composition and BMI-SDS. Of 160 boys enrolled, 126 (80%) completed 6 months' intervention. Baseline age, height-SDS, weight-SDS, BMI-SDS, body composition and dietary intake were similar in the formula and placebo groups. 'Good' formula consumers (intake of ≥50% of the recommended dose, n = 30) gained significantly more in weight-SDS, BMI-SDS, fat-free-mass and muscle mass (p < 0.05) than did 'poor' consumers (n = 35) and the placebo group (n = 61). Only in the formula group, positive dose-response correlations were found between consumption of the formula and changes in the outcome parameters examined, including Δheight-SDS (r = 0.301, p = 0.015). Boys aged >11.4 years who were 'good' formula consumers maintained their Δheight-SDS, while Δheight-SDS declined in 'poor' consumers and the placebo group of the same age (p = 0.033). Intervention with a multi-nutrient, protein-rich formula was effective in increasing weight-SDS, fat-free-mass, muscle mass and BMI-SDS in short and lean prepubertal male adolescents. Good consumption of the formula prevented Δheight-SDS decline in the older participants.
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
141-150Informations de copyright
©2021 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
Références
Spear BA. Adolescent growth and development. J Am Diet Assoc. 2002;102(3):S23-S29.
Cole TJ. Tanner's tempo of growth in adolescence: recent SITAR insights with the Harpenden Growth Study and ALSPAC. Ann Hum Biol. 2020;47(2):181-198.
Hermanussen M. Auxology: an update. Horm Res Paediatr. 2010;74(3):153-164. https://doi.org/10.1159/000317440
Tanner JM. Growth at Adolescence, 2nd ed. Blackwell Scientific Publications; 1962.
Jacob JA, Nair MKC. Protein and micronutrient supplementation in complementing pubertal growth. Indian J Pediatr. 2012;79(1):S84-S91.
Lifshitz F. Nutrition and growth. In: Paige DM, ed. Clinical Nutrition. Nutrition and Growth Supplement 4. C.V. Mosby; 1985. pp. 40-47.
Baron J, Sävendahl L, De Luca F, et al. Short and tall stature: a new paradigm emerges. Nat Rev Endocrinol. 2015;11(12):735-746.
Lebenthal Y, Yackobovitch-Gavan M, Lazar L, et al. Effect of a nutritional supplement on growth in short and lean prepubertal children: a prospective, randomized, double-blind, placebo-controlled study. J Pediatr. 2014;165(6):1190-1193.e1.
Yackobovitch-Gavan M, Lebenthal Y, Lazar L, et al. Effect of nutritional supplementation on growth in short and lean prepubertal children after 1 year of intervention. J Pediatr. 2016;179:154-159.e1.
Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. National Academy Press; 2005.
Roberts JL, Stein AD. The impact of nutritional interventions beyond the first 2 years of life on linear growth: a systematic review and meta-analysis. Adv Nutr. 2017;8(2):323-336.
Lassi ZS, Moin A, Das JK, Salam RA, Bhutta ZA. Systematic review on evidence-based adolescent nutrition interventions. Ann N Y Acad Sci. 2017;1393:34-50.
Campisi S, Carducci B, Söder O, Bhutta Z. The intricate relationship between chronic undernutrition, impaired linear growth and delayed puberty: Is ‘catch-up’ growth possible during adolescence? 2018. Innocenti Working Papers no. 2018-12, UNICEF Office of Research -. Innocenti, Florence.
Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, et al. CDC growth charts: United States. Adv Data. 2000;314:1-27.
Tzameret 3 software. Israel center for disease control and the ministry of health. 2016.
IBM Corp. Released 2017. IBM SPSS Statistics for Windows, Version 25.0. IBM Corp; 2017.
Tanner JM, Davies PS. Clinical longitudinal standards for height and height velocity for North American children. J Pediatr. 1985;107(3):317-329.
Sedlmeyer IL. Palmert MR Delayed puberty: analysis of a large case series from an academic center. J Clin Endocrinol Metab. 2002;87(4):1613-1620.
Solans CV. Lifshitz F Body weight progression and nutritional status of patients with familial short stature with and without constitutional delay in growth. Am J Dis Child. 1992;146:296-302.
Wudy SA, Hagemann S, Dempfle A, et al. Children with idiopathic short stature are poor eaters and have decreased body mass index. Pediatrics. 2005;116(1):e52-57.
Han JC, Balagopal P, Sweeten S, Darmaun D, Mauras N. Evidence for hypermetabolism in boys with constitutional delay of growth and maturation. J Clin Endocrinol Metab. 2006;91(6):2081-2086.
Sarma KVR, Udaykumar P, Balakrishna N, Vijayaraghavan K, Sivakumar BD. Effect of micronutrient supplementation on health and nutritional status of schoolchildren: growth and morbidity. Nutrition. 2006;22(1):S8-S14.
Han JC, Damaso L, Welch S, Balagopal P, Hossain J, Mauras N. Effects of growth hormone and nutritional therapy in boys with constitutional growth delay: a randomized controlled trial. J Pediatr. 2011;158(3):427-432.