Virus-Like Vesicles Based on Semliki Forest Virus-Containing Rabies Virus Glycoprotein Make a Safe and Efficacious Rabies Vaccine Candidate in a Mouse Model.
Animals
Antibodies, Viral
/ blood
B-Lymphocytes
/ immunology
Disease Models, Animal
Female
Genetic Engineering
/ methods
Germinal Center
/ immunology
Glycoproteins
/ genetics
Immunization
/ methods
Male
Mice
Mice, Inbred ICR
Rabies
/ immunology
Rabies Vaccines
/ immunology
Rabies virus
/ immunology
Semliki forest virus
/ immunology
Vaccination
/ methods
Vesiculovirus
/ genetics
Viral Proteins
/ genetics
Semliki Forest virus
glycoprotein
rabies vaccine
virus-like vesicles
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
27 09 2021
27 09 2021
Historique:
pubmed:
5
8
2021
medline:
29
3
2022
entrez:
4
8
2021
Statut:
ppublish
Résumé
Rabies is a fatal zoonosis that causes encephalitis in mammals, and vaccination is the most effective method to control and eliminate rabies. Virus-like vesicles (VLVs), which are characterized as infectious, self-propagating membrane-enveloped particles composed of only Semliki Forest virus (SFV) replicase and vesicular stomatitis virus glycoprotein (VSV-G), have been proven safe and efficient as vaccine candidates. However, previous studies showed that VLVs containing rabies virus glycoprotein (RABV-G) grew at relatively low titers in cells, impeding their potential use as a rabies vaccine. In this study, we constructed novel VLVs by transfection of a mutant SFV RNA replicon encoding RABV-G. We found that these VLVs could self-propagate efficiently in cell culture and could evolve to high titers (approximately 10
Identifiants
pubmed: 34346765
doi: 10.1128/JVI.00790-21
pmc: PMC8475514
doi:
Substances chimiques
Antibodies, Viral
0
Glycoproteins
0
Rabies Vaccines
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0079021Subventions
Organisme : National Natural Science Foundation of China (NSFC)
ID : 31872451
Organisme : National Natural Science Foundation of China (NSFC)
ID : 31872452
Organisme : National Natural Science Foundation of China (NSFC)
ID : 31720103917
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