Prevalence and predictors of bowel dysfunction in a large multiple sclerosis outpatient population: an Italian multicenter study.

Disabled Persons Female Gastrointestinal Diseases Humans Multiple Sclerosis / complications Outpatients Prevalence

Bowel Gut dysfunction Multicenter study Multiple sclerosis Symptoms

Journal

Journal of neurology

ISSN: 1432-1459

Titre abrégé: J Neurol

Pays: Germany

ID NLM: 0423161

Informations de publication

Date de publication:
Mar 2022

Historique:

received: 12 01 2021

accepted: 27 07 2021

revised: 04 06 2021

pubmed: 5 8 2021

medline: 23 2 2022

entrez: 4 8 2021

Statut: ppublish

Résumé

Bowel dysfunction (BD) is reported as a common and disabling symptom in multiple sclerosis (MS) patients. To date, no studies have explored the prevalence of these symptoms in a large multicenter outpatient setting. The aims of the present study are to assess: (i) the prevalence of BD in a large multicenter Italian MS population, and (ii) the correlation between clinico-demographic variables and the severity of BD. Each of the nine participating center screened MS patients prospectively: 1100 subjects were enrolled. All patients underwent the Expanded Disability Status Scale (EDSS) and completed the Neurogenic Bowel Dysfunction score (NBDs). Multivariable linear and logistic regression models were used to assess the association between NBDs and several clinico-demographic variables. Fourteen percent of MS patients showed a moderate/severe BD (NBDs > 10); this percentage increased in patients with high disability, ranging from 26 to 32%. Moderate/severe BD was more frequent in MS patients with: progressive phenotypes, higher disability, older age, and longer disease duration. NBDs severity was predicted by female sex, ambulation impairment and bladder symptoms. This study confirms the relatively high prevalence of moderate/severe BD in a large, multicenter, unselected, outpatient MS population. BD appears to be mainly associated to female sex and MS-related disability.

Identifiants

DOI: 10.1007/s00415-021-10737-w PMID: 34347149 PMC: PMC8857096

pubmed: 34347149

doi: 10.1007/s00415-021-10737-w

pii: 10.1007/s00415-021-10737-w

pmc: PMC8857096

doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

Pagination

1610-1617

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Références

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