A Two-Generation Reproductive Toxicity Study of Lanthanum Nitrate in SD Rats.
Embryo toxicity
Lanthanum nitrate
Liver toxicity
Reproductive toxicity
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
18
05
2021
accepted:
14
07
2021
pubmed:
5
8
2021
medline:
26
4
2022
entrez:
4
8
2021
Statut:
ppublish
Résumé
In order to evaluate the effects of lanthanum nitrate on the development of the parent, offspring, and the third generation of Sprague-Dawley (SD) rats, a two-generation reproductive toxicity experiment, was conducted. Two hundred and forty specific pathogen-free (SPF) healthy SD rats were randomly divided into the control group, low-, medium-, and high-dose group, with 30 male and 30 female rats in each group. The rats in each group were given 0 mg/kg, 10.0 mg/kg, 30.0 mg/kg, and 90.0 mg/kg lanthanum nitrate by gavage, respectively. There was no statistically significant difference between the weight gain and food intake of rats in each group. High-dose lanthanum nitrate had no effect on rat implantation and no embryo toxicity. The absolute and relative liver weights of F1a and F1b male rats in the high-dose group were significantly decreased. The absolute liver and spleen weight of F1b female rats in the high-dose group decreased significantly, but the relative weight did not change significantly. Histopathological examination results showed that there were no significant differences in the effects of different doses of lanthanum nitrate on the uterus, ovaries, oviduct, testes and epididymis, and liver of SD rats. Under the experimental conditions, 90.0 mg/kg lanthanum nitrate had an effect on the liver weight of the SD rats, but there was no liver toxicity. The no visible harmful effect level (NOAEL) of lanthanum nitrate on SD rats' reproduction toxicity is 90 mg/kg.
Identifiants
pubmed: 34347232
doi: 10.1007/s12011-021-02841-9
pii: 10.1007/s12011-021-02841-9
doi:
Substances chimiques
lanthanide nitrate
33A856C3T7
Lanthanum
6I3K30563S
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2268-2282Subventions
Organisme : the National Key R&D Program of China
ID : 2017YFC1600203
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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