Rosacea: An Update in Diagnosis, Classification and Management.

alpha-adrenergic agonist anti-parasitic antibiotic diagnosis dicarboxylic acid erythema laser therapy management phenotype approach phyma retinoids rosacea telangiectasia

Journal

Skin therapy letter
ISSN: 1201-5989
Titre abrégé: Skin Therapy Lett
Pays: Canada
ID NLM: 9891441

Informations de publication

Date de publication:
Jul 2021
Historique:
entrez: 4 8 2021
pubmed: 5 8 2021
medline: 29 10 2021
Statut: ppublish

Résumé

The diagnosis and classification of rosacea has been modified to reflect presenting features. On exclusion of differentials, the diagnosis of rosacea is based on the presence of either (1) phymatous changes, or (2) centrofacial persistent erythema. In their absence, diagnosis can be established by presence of any two of: flushing/transient erythema, papules and pustules, telangiectases, or ocular manifestations. Management of rosacea depends on presenting feature(s), their severity, and impact. General management includes gentle skin care, sun protection, and trigger avoidance. Evidence-based treatment recommendations include topical brimonidine and oxymetazoline for persistent erythema; topical azelaic acid, ivermectin, metronidazole, minocycline and oral doxycycline, tetracycline and isotretinoin for papules and pustules; vascular lasers and light devices for telangiectases; and omega-3 fatty acids and cyclosporine ophthalmic emulsion for ocular rosacea. While surgical or laser therapy can be considered for clinically noninflamed phyma, there are no trials on their utility. Combination therapies include topical brimonidine with topical ivermectin, or topical metronidazole with oral doxycycline. Topical metronidazole, topical ivermectin, and topical azelaic acid are appropriate for maintenance therapy. In conclusion, the updated phenotype approach, based on presenting clinical features, is the foundation for current diagnosis, classification, and treatment of rosacea.

Identifiants

pubmed: 34347259

Substances chimiques

Dermatologic Agents 0
Metronidazole 140QMO216E
Brimonidine Tartrate 4S9CL2DY2H
Doxycycline N12000U13O

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-8

Déclaration de conflit d'intérêts

Cindy Kang and Monica Shah have no conflicts of interest to disclose. Jerry Tan has been a consultant, investigator and/or speaker for Almirall, Bausch, Boots/Walgreens, Cipher, Galderma, L’Oréal, Promius, Sun and Vichy. Disclaimers: This manuscript is an original submission. Views expressed in the submitted article are our own and not official positions of our institutions.

Auteurs

Cindy Na-Young Kang (CN)

Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Monica Shah (M)

Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Jerry Tan (J)

Windsor Clinical Research, Windsor, ON, Canada.
Western University, Schulich School of Medicine, Windsor, ON, Canada.

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Classifications MeSH