Fine Particulate Matter and Dementia Incidence in the Adult Changes in Thought Study.
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
entrez:
4
8
2021
pubmed:
5
8
2021
medline:
17
3
2022
Statut:
ppublish
Résumé
Air pollution may be associated with elevated dementia risk. Prior research has limitations that may affect reliability, and no studies have evaluated this question in a population-based cohort of men and women in the United States. We evaluated the association between time-varying, 10-y average fine particulate matter ( Using the Adult Changes in Thought (ACT) population-based prospective cohort study in Seattle, we linked spatiotemporal model-based We report 1,136 cases of incident dementia among 4,166 individuals with nonmissing APOE status. Mean [mean ± standard deviation (SD)] 10-y average In this prospective cohort study with extensive exposure data and consensus-based outcome ascertainment, elevated long-term exposure to
Sections du résumé
BACKGROUND
Air pollution may be associated with elevated dementia risk. Prior research has limitations that may affect reliability, and no studies have evaluated this question in a population-based cohort of men and women in the United States.
OBJECTIVES
We evaluated the association between time-varying, 10-y average fine particulate matter (
METHODS
Using the Adult Changes in Thought (ACT) population-based prospective cohort study in Seattle, we linked spatiotemporal model-based
RESULTS
We report 1,136 cases of incident dementia among 4,166 individuals with nonmissing APOE status. Mean [mean ± standard deviation (SD)] 10-y average
DISCUSSION
In this prospective cohort study with extensive exposure data and consensus-based outcome ascertainment, elevated long-term exposure to
Identifiants
pubmed: 34347531
doi: 10.1289/EHP9018
pmc: PMC8336685
doi:
Substances chimiques
Air Pollutants
0
Particulate Matter
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
87001Subventions
Organisme : NIEHS NIH HHS
ID : F31 ES030972
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS091272
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005136
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG052354
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES026187
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES007033
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006781
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056711
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057033
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES015459
Pays : United States
Commentaires et corrections
Type : CommentIn
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