Astrocytes regulate ultra-slow arteriole oscillations via stretch-mediated TRPV4-COX-1 feedback.

Animals Arterioles / physiology Astrocytes / physiology Calcium / metabolism Cyclooxygenase 1 / metabolism Feedback, Physiological Female Male Mice, Inbred C57BL Rats, Sprague-Dawley Stress, Mechanical TRPV Cation Channels / metabolism Vasoconstriction Vasodilation
COX-1 TRPV4 arteriole astrocyte awake in vivo calcium cerebral vasomotion endfeet two-photon microscopy ultra-slow

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
03 08 2021
Historique:
received: 20 08 2020
revised: 22 02 2021
accepted: 24 06 2021
entrez: 4 8 2021
pubmed: 5 8 2021
medline: 12 2 2022
Statut: ppublish

Résumé

Very-low-frequency oscillations in microvascular diameter cause fluctuations in oxygen delivery that are important for fueling the brain and for functional imaging. However, little is known about how the brain regulates ongoing oscillations in cerebral blood flow. In mouse and rat cortical brain slice arterioles, we find that selectively enhancing tone is sufficient to recruit a TRPV4-mediated Ca

Identifiants

DOI: 10.1016/j.celrep.2021.109405 PMID: 34348138
pubmed: 34348138
pii: S2211-1247(21)00818-4
doi: 10.1016/j.celrep.2021.109405
pii:
doi:

Substances chimiques

TRPV Cation Channels 0
Trpv4 protein, mouse 0
Trpv4 protein, rat 0
Cyclooxygenase 1 EC 1.14.99.1
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109405

Subventions

Organisme : CIHR
ID : FDN-148471
Pays : Canada
Organisme : Howard Hughes Medical Institute
Pays : United States

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Jordan N Haidey (JN)

Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

Govind Peringod (G)

Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

Adam Institoris (A)

Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

Kelsea A Gorzo (KA)

Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

Wilten Nicola (W)

Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada; Department of Physics and Astronomy, Faculty of Science, University of Calgary, Calgary, AB T2N 1N4, Canada.

Milène Vandal (M)

Hotchkiss Brain Institute, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

Kenichi Ito (K)

Centre for Genome Engineering, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

Shiying Liu (S)

Centre for Genome Engineering, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

Cameron Fielding (C)

Centre for Genome Engineering, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

Frank Visser (F)

Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

Minh Dang Nguyen (MD)

Hotchkiss Brain Institute, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

Grant R Gordon (GR)

Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. Electronic address: gordong@ucalgary.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Astrocytes regulate ultra-slow arteriole...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Microvaisseaux › Artérioles › Astrocytes regulate ultra-slow arteriole...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Astrocytes regulate ultra-slow arteriole...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Astrocytes regulate ultra-slow arteriole...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Cyclooxygenase 1 › Astrocytes regulate ultra-slow arteriole...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Rétrocontrôle physiologique › Astrocytes regulate ultra-slow arteriole...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Astrocytes regulate ultra-slow arteriole...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Astrocytes regulate ultra-slow arteriole...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Contrainte mécanique › Astrocytes regulate ultra-slow arteriole...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › Astrocytes regulate ultra-slow arteriole...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasoconstriction › Astrocytes regulate ultra-slow arteriole...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › Astrocytes regulate ultra-slow arteriole...