Stem cell spreading dynamics intrinsically differentiate acral melanomas from nevi.

Animals Cell Movement / radiation effects Cell Proliferation / radiation effects Cyclin D1 / metabolism Disease Models, Animal Epidermis / pathology Gene Amplification Genomic Instability / radiation effects Melanocytes / pathology Melanoma / diagnosis Mice, Inbred C57BL Nevus / pathology Risk Factors Skin / pathology Skin Pigmentation / radiation effects Stem Cells / pathology Sweat Glands / radiation effects Ultraviolet Rays
acral melanomas acral nevi differential diagnosis eccrine gland melanocyte stem cell melanoma model pigment risk factor stem cells sweat gland

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
03 08 2021
Historique:
received: 14 12 2020
revised: 19 04 2021
accepted: 13 07 2021
entrez: 4 8 2021
pubmed: 5 8 2021
medline: 12 2 2022
Statut: ppublish

Résumé

Early differential diagnosis between malignant and benign tumors and their underlying intrinsic differences are the most critical issues for life-threatening cancers. To study whether human acral melanomas, deadly cancers that occur on non-hair-bearing skin, have distinct origins that underlie their invasive capability, we develop fate-tracing technologies of melanocyte stem cells in sweat glands (glandular McSCs) and in melanoma models in mice and compare the cellular dynamics with human melanoma. Herein, we report that glandular McSCs self-renew to expand their migratory progeny in response to genotoxic stress and trauma to generate invasive melanomas in mice that mimic human acral melanomas. The analysis of melanocytic lesions in human volar skin reveals that genetically unstable McSCs expand in sweat glands and in the surrounding epidermis in melanomas but not in nevi. The detection of such cell spreading dynamics provides an innovative method for an early differential diagnosis of acral melanomas from nevi.

Identifiants

DOI: 10.1016/j.celrep.2021.109492 PMID: 34348144
pubmed: 34348144
pii: S2211-1247(21)00919-0
doi: 10.1016/j.celrep.2021.109492
pii:
doi:

Substances chimiques

Cyclin D1 136601-57-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109492

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Sally Eshiba (S)

Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Department of Dermatology, Tokyo Medical and Dental University Graduate School and Faculty of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Takeshi Namiki (T)

Department of Dermatology, Tokyo Medical and Dental University Graduate School and Faculty of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address: tnamderm@tmd.ac.jp.

Yasuaki Mohri (Y)

Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Tomomi Aida (T)

Department of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Laboratory of Genome Editing for Biomedical Research, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Naotaka Serizawa (N)

Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Takakazu Shibata (T)

Medical Corporation Shibata Dermatology Clinic, 1-1-30 Morinomiya Chuo, Chuo-ku, Osaka 540-0003, Japan.

Hironobu Morinaga (H)

Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Daisuke Nanba (D)

Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Yuichi Hiraoka (Y)

Department of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Laboratory of Genome Editing for Biomedical Research, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Kohichi Tanaka (K)

Department of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Keiko Miura (K)

Department of Pathology, Tokyo Medical and Dental University Graduate School and Faculty of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Masaru Tanaka (M)

Department of Dermatology, Tokyo Women's Medical University Medical Center East, Tokyo, 2-1-10, Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan.

Hisashi Uhara (H)

Department of Dermatology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan.

Hiroo Yokozeki (H)

Department of Dermatology, Tokyo Medical and Dental University Graduate School and Faculty of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Toshiaki Saida (T)

Shinshu University, 7-7-40-220 Kamiochiai, Chuo-ku, Saitama 338-0001, Japan.

Emi K Nishimura (EK)

Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Division of Aging and Regeneration, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Electronic address: emikn@g.ecc.u-tokyo.ac.jp.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Cycline D1 › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Système tégumentaire › Peau › Épiderme › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Amplification de gène › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Cellules › Cellules épithéliales › Mélanocytes › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Naevus › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Système tégumentaire › Peau › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Phénomènes biologiques › Pigmentation › Pigmentation de la peau › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Cellules › Cellules souches › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Système tégumentaire › Peau › Glandes sudoripares › Stem cell spreading dynamics intrinsically...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons ultraviolets › Stem cell spreading dynamics intrinsically...