Severe deficiency of the voltage-gated sodium channel Na

Action Potentials Aging / physiology Animals Down-Regulation Ion Channel Gating Mice, Inbred C57BL NAV1.2 Voltage-Gated Sodium Channel / deficiency Neurons / physiology Potassium Channels / metabolism
K(V)1.1 Na(V)1.2 SCN2A/Scn2a epilepsy gene trap neuronal excitability potassium channel voltage-gated sodium channel

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
03 08 2021
Historique:
received: 10 02 2021
revised: 30 06 2021
accepted: 14 07 2021
entrez: 4 8 2021
pubmed: 5 8 2021
medline: 12 2 2022
Statut: ppublish

Résumé

Scn2a encodes the voltage-gated sodium channel Na

Identifiants

DOI: 10.1016/j.celrep.2021.109495 PMID: 34348148 PMC: PMC8382316
pubmed: 34348148
pii: S2211-1247(21)00922-0
doi: 10.1016/j.celrep.2021.109495
pmc: PMC8382316
mid: NIHMS1730383
pii:
doi:

Substances chimiques

NAV1.2 Voltage-Gated Sodium Channel 0
Potassium Channels 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

109495

Subventions

Organisme : NCI NIH HHS
ID : P30 CA082709
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA212403
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS117585
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023168
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002529
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS123154
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Références

J Physiol. 2002 Jun 1;541(Pt 2):467-82
pubmed: 12042352
Epilepsia. 2019 Dec;60 Suppl 3:S86-S91
pubmed: 31904118
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Neurosci Lett. 2008 Sep 5;442(1):69-73
pubmed: 18601978
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Front Cell Neurosci. 2014 Sep 23;8:297
pubmed: 25294986
J Neurosci. 2013 Apr 24;33(17):7368-83
pubmed: 23616543
Nat Protoc. 2009;4(8):1184-91
pubmed: 19617889
Sci Rep. 2015 Aug 05;5:12813
pubmed: 26242757
J Neurosci. 2010 Dec 15;30(50):16922-37
pubmed: 21159963
Neuroscience. 2010 Mar 10;166(1):195-200
pubmed: 20006674
J Neurosci. 2019 Apr 17;39(16):3159-3169
pubmed: 30755487
Nat Neurosci. 2009 Aug;12(8):996-1002
pubmed: 19633666
Elife. 2018 Nov 01;7:
pubmed: 30382937
Brain. 2019 Feb 1;142(2):362-375
pubmed: 30601941
Hippocampus. 2016 Mar;26(3):380-404
pubmed: 26342161
Brain. 2017 May 1;140(5):1316-1336
pubmed: 28379373
Brain. 2019 May 1;142(5):1282-1295
pubmed: 30938430
Commun Biol. 2018;1:96
pubmed: 30175250
Neurol Genet. 2016 Aug 22;2(5):e96
pubmed: 27602407
Sci Transl Med. 2012 Nov 21;4(161):161ra152
pubmed: 23147003
J Neurosci. 2017 Jun 14;37(24):5846-5860
pubmed: 28522735
J Physiol. 2005 May 1;564(Pt 3):803-15
pubmed: 15760941
Sci Rep. 2020 Feb 21;10(1):3213
pubmed: 32081855
J Physiol. 2018 Jan 15;596(2):317-342
pubmed: 29178354
Trends Neurosci. 2018 Jul;41(7):442-456
pubmed: 29691040
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Genome Biol. 2014;15(12):550
pubmed: 25516281
Front Neural Circuits. 2013 Oct 01;7:153
pubmed: 24101895
Epilepsia. 2021 Jan;62(1):258-268
pubmed: 33236786
J Neurophysiol. 2016 Feb 1;115(2):947-57
pubmed: 26609114
Front Mol Neurosci. 2019 Jun 04;12:145
pubmed: 31249508
Neuroscientist. 2018 Aug;24(4):368-380
pubmed: 29542386
J Physiol. 2003 Apr 1;548(Pt 1):1-20
pubmed: 12611922
Nat Neurosci. 2016 Feb;19(2):223-32
pubmed: 26691832
Nat Neurosci. 2017 Aug;20(8):1172-1179
pubmed: 28671695
Neuron. 2018 Sep 19;99(6):1355
pubmed: 30236286
J Neurosci. 2008 Dec 31;28(53):14329-40
pubmed: 19118165
Nat Neurosci. 2014 Jun;17(6):764-72
pubmed: 24866042
J Pharmacol Exp Ther. 2020 Jun;373(3):391-401
pubmed: 32217768
Genesis. 2004 Mar;38(3):151-8
pubmed: 15048813
Nature. 2011 Jun 15;474(7351):337-42
pubmed: 21677750
J Physiol. 2006 Mar 1;571(Pt 2):371-89
pubmed: 16373387
Nature. 2016 Feb 25;530(7591):481-4
pubmed: 26886798
Channels (Austin). 2017 Nov 2;11(6):534-554
pubmed: 28922053
Biophys J. 2000 Jun;78(6):2878-91
pubmed: 10827969
Science. 2006 Aug 18;313(5789):976-9
pubmed: 16917065
J Neurosci. 2019 Sep 11;39(37):7438-7449
pubmed: 31350261
FEBS Lett. 2000 Sep 1;480(2-3):137-41
pubmed: 11034315
Nat Neurosci. 2005 May;8(5):650-6
pubmed: 15852012
Nat Commun. 2016 Nov 08;7:13316
pubmed: 27824329
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Neuroscience. 2020 Oct 1;445:50-68
pubmed: 32059984
J Physiol. 2000 Jun 15;525 Pt 3:593-609
pubmed: 10856115
Neuroscience. 2012 Oct 25;223:429-38
pubmed: 22858596
Front Neural Circuits. 2012 Jul 27;6:47
pubmed: 22866029
J Physiol. 2010 Sep 1;588(Pt 17):3187-200
pubmed: 20519310
J Neurosci. 2017 Jan 18;37(3):576-586
pubmed: 28100740
Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7184-E7192
pubmed: 29991598
Neurobiol Dis. 2020 Apr;137:104759
pubmed: 31978607
Epilepsia. 2019 Dec;60 Suppl 3:S59-S67
pubmed: 31904126
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Cell Rep. 2021 Aug 3;36(5):109483
pubmed: 34348157
Biochem Biophys Res Commun. 2017 Sep 30;491(4):1070-1076
pubmed: 28784306
Nat Commun. 2014 Nov 21;5:5525
pubmed: 25413837
Neuron. 2020 Dec 9;108(5):876-886.e4
pubmed: 33108748
Nat Methods. 2014 Jul;11(7):763-72
pubmed: 24908100
Nat Genet. 2004 Jun;36(6):543-4
pubmed: 15167922
Mol Pharmacol. 2010 Dec;78(6):1088-95
pubmed: 20843955
Front Cell Neurosci. 2017 Apr 24;11:115
pubmed: 28484374
J Pharmacol Sci. 2017 Apr;133(4):223-231
pubmed: 28391996
Neuron. 2020 Apr 22;106(2):277-290.e6
pubmed: 32075716
Genes Brain Behav. 2021 Apr;20(4):e12725
pubmed: 33369088
Neuron. 2017 Mar 8;93(5):1165-1179.e6
pubmed: 28238546
Toxicol In Vitro. 2010 Mar;24(2):397-403
pubmed: 19895883
Front Neurosci. 2016 Feb 09;10:27
pubmed: 26903795
Nature. 2012 Apr 04;485(7397):237-41
pubmed: 22495306
Hum Mol Genet. 2015 Mar 1;24(5):1457-68
pubmed: 25378553
Epilepsia. 2019 Dec;60 Suppl 3:S68-S76
pubmed: 31904120
Nat Commun. 2019 Apr 23;10(1):1917
pubmed: 31015467
J Neurosci. 2009 Sep 2;29(35):10979-88
pubmed: 19726656
Bioinformatics. 2005 Aug 15;21(16):3439-40
pubmed: 16082012
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2383-2388
pubmed: 28193882
Cell. 2020 Feb 6;180(3):568-584.e23
pubmed: 31981491
Nat Rev Drug Discov. 2009 Dec;8(12):982-1001
pubmed: 19949402
J Membr Biol. 2009 Mar;228(1):1-14
pubmed: 19219384
Annu Rev Neurosci. 2012;35:249-65
pubmed: 22443507
Neuron. 2019 Aug 21;103(4):673-685.e5
pubmed: 31230762
J Neurosci. 1992 Jun;12(6):2259-67
pubmed: 1318958
Biol Psychiatry. 2017 Aug 1;82(3):224-232
pubmed: 28256214

Auteurs

Jingliang Zhang (J)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

Xiaoling Chen (X)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Muriel Eaton (M)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

Jiaxiang Wu (J)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

Zhixiong Ma (Z)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

Shirong Lai (S)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

Anthony Park (A)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

Talha S Ahmad (TS)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

Zhefu Que (Z)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

Ji Hea Lee (JH)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

Tiange Xiao (T)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

Yuansong Li (Y)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

Yujia Wang (Y)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

Maria I Olivero-Acosta (MI)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.

James A Schaber (JA)

Bioscience Imaging Facility, Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA.

Krishna Jayant (K)

Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Chongli Yuan (C)

Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Zhuo Huang (Z)

Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.

Nadia A Lanman (NA)

Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA; Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.

William C Skarnes (WC)

The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.

Yang Yang (Y)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA. Electronic address: yangyang@purdue.edu.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Severe deficiency of the voltage-gated sodium...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Severe deficiency of the voltage-gated sodium...
questionsmedicales.fr › Eucaryotes › Animaux › Severe deficiency of the voltage-gated sodium...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › Severe deficiency of the voltage-gated sodium...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes électrophysiologiques › Ouverture et fermeture des portes des canaux ioniques › Severe deficiency of the voltage-gated sodium...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Severe deficiency of the voltage-gated sodium...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.2 › Severe deficiency of the voltage-gated sodium...
questionsmedicales.fr › Cellules › Neurones › Severe deficiency of the voltage-gated sodium...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Severe deficiency of the voltage-gated sodium...