Genetic Evidence on the Association of Interleukin (IL)-1-Mediated Chronic Inflammation with Airflow Obstruction: A Mendelian Randomization Study.
Airway Obstruction
/ genetics
Chronic Disease
Female
Genome-Wide Association Study
Humans
Inflammation
/ genetics
Intercellular Signaling Peptides and Proteins
/ genetics
Interleukin 1 Receptor Antagonist Protein
/ genetics
Interleukin-1
/ genetics
Male
Mendelian Randomization Analysis
Middle Aged
Polymorphism, Single Nucleotide
Pulmonary Disease, Chronic Obstructive
/ genetics
Receptors, Interleukin-1
/ genetics
Airflow obstruction
IL-1
IL-1 receptor antagonists
IL-1 receptors
Mendelian randomization
Journal
COPD
ISSN: 1541-2563
Titre abrégé: COPD
Pays: England
ID NLM: 101211769
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
pubmed:
6
8
2021
medline:
13
1
2022
entrez:
5
8
2021
Statut:
ppublish
Résumé
Preclinical studies suggest interleukin (IL)-1α/β is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, recent trials of anti-IL-1 therapies showed limited benefit for COPD. To clarify, we primarily examined total and direct effects of IL-1 and its receptors/coreceptors/receptor antagonists (IL-1/IL-1Rs) on airflow obstruction (AO) using Mendelian randomization (MR), and secondarily explored reverse causation using bidirectional MR. We selected independent
Identifiants
pubmed: 34348529
doi: 10.1080/15412555.2021.1955848
doi:
Substances chimiques
Intercellular Signaling Peptides and Proteins
0
Interleukin 1 Receptor Antagonist Protein
0
Interleukin-1
0
Receptors, Interleukin-1
0
interleukin-18 binding protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM