Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
Animals
Basic Helix-Loop-Helix Transcription Factors
/ genetics
Calcium
/ metabolism
Calcium Channels, L-Type
/ metabolism
Cell Death
HEK293 Cells
Humans
Infarction, Middle Cerebral Artery
/ metabolism
Ischemic Stroke
/ genetics
Male
Mice, Inbred C57BL
Mice, Knockout
Monomeric GTP-Binding Proteins
/ genetics
Neurons
/ metabolism
Organoids
Npas4
ischemic stroke
neural activity–dependent
neuroplasticity
neuroprotection
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
10 08 2021
10 08 2021
Historique:
entrez:
5
8
2021
pubmed:
6
8
2021
medline:
4
1
2022
Statut:
ppublish
Résumé
Ischemic stroke, which results in loss of neurological function, initiates a complex cascade of pathological events in the brain, largely driven by excitotoxic Ca
Identifiants
pubmed: 34349016
pii: 2018850118
doi: 10.1073/pnas.2018850118
pmc: PMC8364162
pii:
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
Calcium Channels, L-Type
0
Npas4 protein, mouse
0
GEM protein, human
EC 3.6.5.2
Gem protein, mouse
EC 3.6.5.2
Monomeric GTP-Binding Proteins
EC 3.6.5.2
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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