Challenges in Diabetic Macular Edema Management: An Expert Consensus Report.
biomarkers
consensus
diabetes
diabetic macular edema
inflammation
optical coherence tomography
Journal
Clinical ophthalmology (Auckland, N.Z.)
ISSN: 1177-5467
Titre abrégé: Clin Ophthalmol
Pays: New Zealand
ID NLM: 101321512
Informations de publication
Date de publication:
2021
2021
Historique:
received:
25
05
2021
accepted:
23
06
2021
entrez:
5
8
2021
pubmed:
6
8
2021
medline:
6
8
2021
Statut:
epublish
Résumé
This paper aimed to present daily-practice recommendations for the management of diabetic macular edema (DME) patients based on available scientific evidence and the clinical experience of the consensus panel. A group of Spanish retina experts agreed to discuss different aspects related with the clinical management of DME patients. Panel was mainly focused on therapeutic objectives in DME management; definition terms; and role of biomarkers as prognostic and predictive factors to intravitreal treatment response. The panel recommends to start DME treatment as soon as possible in those eyes with a visual acuity less than 20/25 (always according to the retina unit capacity). Naïve patient was defined, in a strict manner, as a patient who, up to that moment, had never received any treatment. A refractory DME patient may be defined as the one who did not achieve a complete resolution of the disease, regardless of the treatment administered. Different optical coherence tomography biomarkers, such as disorganization of the retinal inner layers, hyperreflective dots, and cysts, have been identified as prognostic factors. This document has sought to lay down a set of recommendations and to identify key issues that may be useful for the daily management of DME patients.
Identifiants
pubmed: 34349495
doi: 10.2147/OPTH.S320948
pii: 320948
pmc: PMC8327476
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3183-3195Informations de copyright
© 2021 Udaondo et al.
Déclaration de conflit d'intérêts
Dr Patricia Udaondo reports grants from Allergan, an AbbVie company, during the conduct of the study. Dr Veronica Castro-Navarro reports grants from Allergan, an AbbVie company, over the last year. Dr José María Ruiz Moreno reports grants from Allergan, an AbbVie company, over the last year. Dr Javier Ascaso reports personal fees from Allergan, personal fees from Novartis, personal fees from Bayer, personal fees from Brill Pharma, personal fees from Alcon, outside the submitted work. Dr Alfredo García-Layana reports personal fees from Allergan, personal fees from Novartis, personal fees from Bayer, personal fees from Roche, grants, personal fees from Thea, during the conduct of the study. Dr Francisco Javier Lavid reports personal fees from Allergan, during the conduct of the study; personal fees from Novartis, personal fees from Bayer, personal fees from Allergan, outside the submitted work. The authors report no other conflicts of interest in this work.
Références
Ophthalmology. 2018 Feb;125(2):267-275
pubmed: 28935399
Korean J Ophthalmol. 2018 Apr;32(2):116-125
pubmed: 29560616
J Diabetes Complications. 2014 Mar-Apr;28(2):166-70
pubmed: 24374138
Br J Ophthalmol. 2018 Feb;102(2):195-203
pubmed: 28724636
Ophthalmology. 2015 Oct;122(10):2044-52
pubmed: 26198808
Acta Ophthalmol. 2019 Jun;97(4):e540-e544
pubmed: 30318792
Ophthalmol Retina. 2019 Nov;3(11):917-919
pubmed: 31699307
Am J Ophthalmol. 2006 Sep;142(3):405-12
pubmed: 16935584
Semin Ophthalmol. 2017;32(1):56-66
pubmed: 28060586
J Ophthalmol. 2017;2017:4834201
pubmed: 28819567
Arch Soc Esp Oftalmol. 2016 Jun;91(6):273-80
pubmed: 26810908
Graefes Arch Clin Exp Ophthalmol. 2005 Jan;243(1):20-5
pubmed: 15290152
Retina. 2016 Dec;36(12):2319-2328
pubmed: 27258668
Ophthalmology. 2020 Mar;127(3):427-429
pubmed: 31767437
BMC Ophthalmol. 2016 Aug 04;16:136
pubmed: 27491545
Korean J Ophthalmol. 2018 Aug;32(4):296-302
pubmed: 30091308
Acta Ophthalmol. 2017 Aug;95(5):464-471
pubmed: 27775223
J Ophthalmol. 2019 Feb 17;2019:8216150
pubmed: 30906587
Ophthalmology. 2018 Oct;125(10):1608-1622
pubmed: 29776671
Indian J Ophthalmol. 2010 Sep-Oct;58(5):381-4
pubmed: 20689191
Ophthalmologica. 2021;244(1):83-92
pubmed: 33045712
J Diabetes Complications. 2019 Dec;33(12):107417
pubmed: 31669065
Graefes Arch Clin Exp Ophthalmol. 2009 Oct;247(10):1325-30
pubmed: 19430805
BMC Ophthalmol. 2016 Jan 18;16:12
pubmed: 26781272
Eye (Lond). 2006 Jun;20(6):674-80
pubmed: 16244647
Retina. 2016 Oct;36(10):1823-42
pubmed: 27328171
Br J Ophthalmol. 2002 Jul;86(7):716-22
pubmed: 12084735
Retina. 2007 Jun;27(5):552-6
pubmed: 17558315
Ophthalmology. 2015 Dec;122(12):2504-13.e1
pubmed: 26452713
Medicine (Baltimore). 2019 Dec;98(51):e18333
pubmed: 31860985
Retina. 2019 Jan;39(1):88-97
pubmed: 29474302
Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT341-7
pubmed: 27409491
Retina. 2017 Nov;37(11):2015-2024
pubmed: 28092342
Ophthalmology. 2016 Jun;123(6):1351-9
pubmed: 26935357
Retina. 2018 Apr;38(4):805-811
pubmed: 28333881
Retina. 2011 May;31(5):915-23
pubmed: 21487341
Retina. 2013 Apr;33(4):740-7
pubmed: 23222391
Ophthalmology. 1987 Jul;94(7):761-74
pubmed: 3658348
Br J Ophthalmol. 2017 Jun;101(6):791-795
pubmed: 27625164
Am J Ophthalmol Case Rep. 2019 Nov 07;16:100567
pubmed: 31788575
Diabetes Res Clin Pract. 2018 Aug;142:243-253
pubmed: 29879494
Diabetes Res Clin Pract. 2018 Apr;138:271-281
pubmed: 29496507
BMC Ophthalmol. 2019 Jan 11;19(1):15
pubmed: 30634940
JAMA Ophthalmol. 2018 Mar 1;136(3):257-269
pubmed: 29392288
Eur J Ophthalmol. 2019 Nov;29(6):573-584
pubmed: 31238719
Ophthalmology. 2010 Dec;117(12):2379-86
pubmed: 20561684
Retina. 2015 Mar;35(3):449-53
pubmed: 25170862
Curr Diab Rep. 2019 Aug 31;19(10):95
pubmed: 31473838
Ophthalmology. 2012 Apr;119(4):789-801
pubmed: 22330964
Arch Ophthalmol. 1995 Sep;113(9):1144-55
pubmed: 7661748
J Ophthalmol. 2018 Oct 3;2018:1089043
pubmed: 30402277
Retina. 2018 Apr;38(4):812-819
pubmed: 28406860
Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):715-721
pubmed: 29392317
Sci Rep. 2019 Jul 29;9(1):10952
pubmed: 31358777
Am J Ophthalmol. 1999 Jun;127(6):688-93
pubmed: 10372879
JAMA Ophthalmol. 2015 Jul;133(7):820-5
pubmed: 25950417
Graefes Arch Clin Exp Ophthalmol. 2001 Feb;239(2):96-101
pubmed: 11372551
Pharmacoeconomics. 2006;24(2):193-205
pubmed: 16460138
Graefes Arch Clin Exp Ophthalmol. 2019 Nov;257(11):2381-2390
pubmed: 31451909
Acta Ophthalmol. 2013 Nov;91(7):e529-36
pubmed: 23647578
Jpn J Ophthalmol. 2019 May;63(3):234-242
pubmed: 30783942
Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5541-5546
pubmed: 27768792
Ophthalmologica. 2018;240(2):61-72
pubmed: 29617689
Ophthalmology. 2013 Oct;120(10):2013-22
pubmed: 23706949
Ophthalmologica. 2011;226(2):57-63
pubmed: 21555906
Int Ophthalmol. 2017 Apr;37(2):333-339
pubmed: 27221365
Eur J Epidemiol. 2020 Jan;35(1):11-23
pubmed: 31515657
Ophthalmology. 2005 Oct;112(10):1747-57
pubmed: 16154196
Int Ophthalmol. 2019 Apr;39(4):821-828
pubmed: 29524030
PLoS One. 2018 Oct 31;13(10):e0206482
pubmed: 30379920
Ophthalmology. 2014 Oct;121(10):1892-903
pubmed: 24935282
Acta Diabetol. 2019 Jul;56(7):777-784
pubmed: 30903434
Ophthalmologica. 2017;237(4):185-222
pubmed: 28423385
Biomed Res Int. 2015;2015:981471
pubmed: 26167510
Ophthalmologica. 2010;224 Suppl 1:2-7
pubmed: 20714175
Ophthalmology. 2011 Jun;118(6):1107-18
pubmed: 21529957
Ophthalmology. 2016 Jun;123(6):1399-401
pubmed: 26783096
Curr Diab Rep. 2019 Jul 29;19(9):68
pubmed: 31359157
Am J Ophthalmol. 2010 Jul;150(1):63-67.e1
pubmed: 20451897
Invest Ophthalmol Vis Sci. 2017 Nov 1;58(13):5958-5967
pubmed: 29183041
JAMA Ophthalmol. 2016 Feb;134(2):127-34
pubmed: 26605836
Eye (Lond). 2020 Mar;34(3):480-490
pubmed: 31320738
Int Ophthalmol. 2018 Feb;38(1):241-249
pubmed: 28160192
Eye (Lond). 2021 May;35(5):1490-1495
pubmed: 32690922
Ophthalmology. 2015 Jul;122(7):1395-401
pubmed: 25870079
Ophthalmology. 2014 Nov;121(11):2247-54
pubmed: 25012934
Ophthalmology. 2014 Dec;121(12):2473-81
pubmed: 25155371
Expert Opin Pharmacother. 2020 Mar;21(4):467-475
pubmed: 31957495
JAMA Ophthalmol. 2014 Nov;132(11):1309-16
pubmed: 25058813
JAMA. 2019 May 21;321(19):1880-1894
pubmed: 31037289
Graefes Arch Clin Exp Ophthalmol. 2012 Jan;250(1):61-70
pubmed: 21874345
Acta Ophthalmol. 2020 Mar;98(2):e217-e223
pubmed: 31421028
Asia Pac J Ophthalmol (Phila). 2018 Jan-Feb;7(1):22-27
pubmed: 29376234
Retina. 2012 Nov-Dec;32(10):2150-7
pubmed: 22617833
Indian J Ophthalmol. 2018 Dec;66(12):1736-1750
pubmed: 30451174
Int J Ophthalmol. 2019 Mar 18;12(3):442-450
pubmed: 30918814
Br J Ophthalmol. 2018 May;102(5):575-585
pubmed: 29545417
Retina. 2014 Apr;34(4):741-8
pubmed: 23975003
Ophthalmology. 2013 Sep;120(9):1843-51
pubmed: 23706947
JAMA Ophthalmol. 2018 Jan 1;136(1):29-38
pubmed: 29127949
Indian J Ophthalmol. 2015 May;63(5):416-22
pubmed: 26139803
Mol Vis. 2013 Aug 04;19:1760-8
pubmed: 23922493
J Ocul Pharmacol Ther. 2019 Dec;35(10):551-557
pubmed: 31603371
JAMA Ophthalmol. 2018 Feb 1;136(2):202-208
pubmed: 29327033
Ophthalmology. 2016 Apr;123(4):850-7
pubmed: 26832658
N Engl J Med. 2015 Mar 26;372(13):1193-203
pubmed: 25692915
Ophthalmology. 2011 Apr;118(4):626-635.e2
pubmed: 21459216
Ophthalmologica. 2018;239(4):205-214
pubmed: 29402873