Intervertebral disc therapies for non-specific chronic low back pain: a systematic review and meta-analysis.
intervertebral disc
intradiscal therapy
low back pain
systematic review
Journal
Therapeutic advances in musculoskeletal disease
ISSN: 1759-720X
Titre abrégé: Ther Adv Musculoskelet Dis
Pays: England
ID NLM: 101517322
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
01
2021
accepted:
08
06
2021
entrez:
5
8
2021
pubmed:
6
8
2021
medline:
6
8
2021
Statut:
epublish
Résumé
We aim to evaluate the benefits and harms of intervertebral disc therapies (IDTs) in people with non-specific chronic low back pain (NScLBP). We conducted a systematic review and meta-analysis of randomized trials of IDTs Of 18 eligible trials (among 1396 citations), five assessed glucocorticoids (GCs) IDTs and were included in a quantitative synthesis; 13 assessed other products including etanercept ( GC IDTs are associated with a reduction in LBP intensity at short term in people with NScLBP. Positive effects are not sustained. IDTs have no effect on activity limitations. Our conclusions are limited by high heterogeneity and a limited methodological quality across studies. PROSPERO: CRD42019106336.
Identifiants
pubmed: 34349845
doi: 10.1177/1759720X211028001
pii: 10.1177_1759720X211028001
pmc: PMC8287365
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1759720X211028001Informations de copyright
© The Author(s), 2021.
Déclaration de conflit d'intérêts
Conflict of interest statement: AF, MMLC, FR and CN are authors of the following article “Nguyen C, Boutron I, Baron G, Sanchez K, Palazzo C, Benchimol R, Paris G, James-Belin É, Lefèvre-Colau MM, Beaudreuil J, Laredo JD, Béra-Louville A, Cotten A, Drapé JL, Feydy A, Ravaud P, Rannou F, Poiraudeau S. Intradiscal Glucocorticoid Injection for Patients With Chronic Low Back Pain Associated With Active Discopathy: A Randomized Trial. Ann Intern Med. 2017 Apr18; 166(8):547–556,” which reported the positive effect of an intradiscal injection of glucocorticoids on pain at short term in patients with chronic low back pain and active discopathy.
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