Alopecia Areata: An Autoimmune Disease of Multiple Players.
alopecia totalis
alopecia universalis
autoimmunity
hair loss
inflammation
Journal
ImmunoTargets and therapy
ISSN: 2253-1556
Titre abrégé: Immunotargets Ther
Pays: New Zealand
ID NLM: 101606565
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
06
2021
accepted:
17
07
2021
entrez:
5
8
2021
pubmed:
6
8
2021
medline:
6
8
2021
Statut:
epublish
Résumé
Alopecia areata (AA) is an autoimmune disease of the hair follicles. It is characterized by a well-defined non-scarring alopecic patch or patches that may extend to the entire scalp or lead to total body hair loss. Due to its unpredictable clinical course, AA causes substantial psychological harm. Despite the high prevalence of this disease and extensive research, its exact pathomechanism is unclear, and current treatments have a high relapse rate that has deemed AA incurable. Over the past few decades, researchers have investigated multiple potential factors that may help alleviate its pathogenesis and provide effective treatment. Given its complex immunopathogenesis, AA is considered an autoimmune disease with multiple factors. This review gathers current evidence that emphasizes molecular mechanisms, possible causative etiologies, and targeted immunotherapies for AA. Understanding its underlying mechanisms may shed light on new strategies to effectively manage AA in the future.
Identifiants
pubmed: 34350136
doi: 10.2147/ITT.S266409
pii: 266409
pmc: PMC8328385
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
299-312Informations de copyright
© 2021 Suchonwanit et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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