Molecular characterization of canine parvovirus from domestic dogs in Nigeria: Introduction and spread of a CPV-2c mutant and replacement of older CPV-2a by the "new CPV-2a" strain.
Canine parvovirus
Molecular characterization
Mutations
Nigeria
Predicted amino acid changes
Protoparvovirus
Journal
Virusdisease
ISSN: 2347-3584
Titre abrégé: Virusdisease
Pays: India
ID NLM: 101624144
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
09
03
2020
accepted:
10
04
2021
entrez:
5
8
2021
pubmed:
6
8
2021
medline:
6
8
2021
Statut:
ppublish
Résumé
Canine parvovirus (CPV) is a contagious and highly pathogenic virus of dogs. After its first report in 1978, the CPV original type (CPV-2) was rapidly and totally replaced by three antigenic variants named CPV-2a, CPV-2b and CPV-2c that circulate in various countries at different frequencies and recently reported in Nigeria. This study describes the molecular characterization of 28 CPV strains in dogs presenting with gastroenteritis in veterinary clinics at Lagos and Ibadan, Nigeria. The results show the predominance (92.8%) of CPV-2a, while CPV-2c was found only in two samples. Phylogenetic analyses revealed that the CPV Nigerian strains were closely related to Asian strains and 26 CPV-2a out of 28 CPV sequences fell into 2 different subclades consistent with predicted amino acid mutations at position 267, 321, 324 and 440. Lys321Asn was evident in all the Nigerian strains whilst Phe267Tyr and Tyr324Ile were observed in 96.4% of the sequences, respectively. Thr440Ala occurred in 89.3% of sequences from this study. The new CPV-2a was predominant and appears to have replaced other CPV-2a strains in South-western Nigeria whilst the CPV-2c strain which is identical to the isolate recently reported in Northern Nigeria, may have been introduced in this country at the time of this study. Monitoring virus epidemiology is important to better understand the dynamics of CPV evolution and the eventual need to change or improve existing vaccination strategies.
Identifiants
pubmed: 34350320
doi: 10.1007/s13337-021-00689-0
pii: 689
pmc: PMC8324694
doi:
Types de publication
Journal Article
Langues
eng
Pagination
361-368Informations de copyright
© Indian Virological Society 2021.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare that there is no conflict of interests regarding the publication of this article.
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