Classification of Myocardial

Computer Aided Diagnosis Computer Application-Detection/Diagnosis Heart PET

Journal

Radiology. Artificial intelligence
ISSN: 2638-6100
Titre abrégé: Radiol Artif Intell
Pays: United States
ID NLM: 101746556

Informations de publication

Date de publication:
Jul 2021
Historique:
received: 30 06 2020
revised: 17 02 2021
accepted: 11 03 2021
entrez: 5 8 2021
pubmed: 6 8 2021
medline: 6 8 2021
Statut: epublish

Résumé

To perform automated myocardial segmentation and uptake classification from whole-body fluorine 18 fluorodeoxyglucose (FDG) PET. In this retrospective study, consecutive patients who underwent FDG PET imaging for oncologic indications were included (July-August 2018). The left ventricle (LV) on whole-body FDG PET images was manually segmented and classified as showing no myocardial uptake, diffuse uptake, or partial uptake. A total of 609 patients (mean age, 64 years ± 14 [standard deviation]; 309 women) were included and split between training (60%, 365 patients), validation (20%, 122 patients), and testing (20%, 122 patients) datasets. Two sequential neural networks were developed to automatically segment the LV and classify the myocardial uptake pattern using segmentation and classification training data provided by human experts. Linear regression was performed to correlate findings from human experts and deep learning. Classification performance was evaluated using receiver operating characteristic (ROC) analysis. There was moderate agreement of uptake pattern between experts and deep learning (as a fraction of correctly categorized images) with 78% (36 of 46) for no uptake, 71% (34 of 48) for diffuse uptake, and 71% (20 of 28) for partial uptake. There was no bias in LV volume for partial or diffuse uptake categories Deep learning was able to segment and classify myocardial uptake patterns on FDG PET images.

Identifiants

DOI: 10.1148/ryai.2021200148 PMID: 34350405 PMC: PMC8328107
pubmed: 34350405
doi: 10.1148/ryai.2021200148
pmc: PMC8328107
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e200148

Subventions

Organisme : NIBIB NIH HHS
ID : T32 EB009384
Pays : United States

Informations de copyright

2021 by the Radiological Society of North America, Inc.

Déclaration de conflit d'intérêts

Disclosures of Conflicts of Interest: N.J. Activities related to the present article: institution receives grant (1R01HL137984-01A1). Activities not related to the present article: disclosed no relevant relationships. Other relationships: disclosed no relevant relationships. M.T.M. Activities related to the present article: author received grant from Sarnoff Cardiovascular Research Foundation. Activities not related to the present article: disclosed no relevant relationships. Other relationships: disclosed no relevant relationships. C.J. disclosed no relevant relationships. B.F. Activities related to the present article: given minimum wage through grant money. Activities not related to the present article: disclosed no relevant relationships. Other relationships: disclosed no relevant relationships. B.F.M. Activities related to the present article: paid consulting fee or honorarium by University of Pennsylvania. Activities not related to the present article: disclosed no relevant relationships. Other relationships: disclosed no relevant relationships. E.H. disclosed no relevant relationships. S.K.I. disclosed no relevant relationships. H.L. disclosed no relevant relationships. Y.H. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: author was consultant for GE Healthcare; institution has grants from Gilead and Pfizer. Other relationships: disclosed no relevant relationships. F.K. disclosed no relevant relationships. P.E.B. disclosed no relevant relationships. W.R.W. Activities related to the present article: institution received grant from National Institutes of Health/National Heart, Lung, and Blood Institute (1R01HL137984-01A1). Activities not related to the present article: disclosed no relevant relationships. Other relationships: disclosed no relevant relationships.

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Auteurs

Nicholas Josselyn (N)

Departments of Radiology (N.J., M.T.M., C.J., B.F., H.L., Y.H., F.K., P.E.B., W.R.W.), Bioengineering (B.F.M., E.H., S.K.I.), and Medicine (Y.H., P.B.), Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104.

Matthew T MacLean (MT)

Departments of Radiology (N.J., M.T.M., C.J., B.F., H.L., Y.H., F.K., P.E.B., W.R.W.), Bioengineering (B.F.M., E.H., S.K.I.), and Medicine (Y.H., P.B.), Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104.

Christopher Jean (C)

Departments of Radiology (N.J., M.T.M., C.J., B.F., H.L., Y.H., F.K., P.E.B., W.R.W.), Bioengineering (B.F.M., E.H., S.K.I.), and Medicine (Y.H., P.B.), Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104.

Ben Fuchs (B)

Departments of Radiology (N.J., M.T.M., C.J., B.F., H.L., Y.H., F.K., P.E.B., W.R.W.), Bioengineering (B.F.M., E.H., S.K.I.), and Medicine (Y.H., P.B.), Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104.
ORCID: 0000-0002-5346-7195

Brianna F Moon (BF)

Departments of Radiology (N.J., M.T.M., C.J., B.F., H.L., Y.H., F.K., P.E.B., W.R.W.), Bioengineering (B.F.M., E.H., S.K.I.), and Medicine (Y.H., P.B.), Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104.
ORCID: 0000-0003-0642-0551

Eileen Hwuang (E)

Departments of Radiology (N.J., M.T.M., C.J., B.F., H.L., Y.H., F.K., P.E.B., W.R.W.), Bioengineering (B.F.M., E.H., S.K.I.), and Medicine (Y.H., P.B.), Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104.
ORCID: 0000-0002-7376-2810

Srikant Kamesh Iyer (SK)

Departments of Radiology (N.J., M.T.M., C.J., B.F., H.L., Y.H., F.K., P.E.B., W.R.W.), Bioengineering (B.F.M., E.H., S.K.I.), and Medicine (Y.H., P.B.), Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104.

Harold Litt (H)

Departments of Radiology (N.J., M.T.M., C.J., B.F., H.L., Y.H., F.K., P.E.B., W.R.W.), Bioengineering (B.F.M., E.H., S.K.I.), and Medicine (Y.H., P.B.), Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104.
ORCID: 0000-0003-2394-6053

Yuchi Han (Y)

Departments of Radiology (N.J., M.T.M., C.J., B.F., H.L., Y.H., F.K., P.E.B., W.R.W.), Bioengineering (B.F.M., E.H., S.K.I.), and Medicine (Y.H., P.B.), Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104.
ORCID: 0000-0001-7582-1848

Fatemeh Kaghazchi (F)

Departments of Radiology (N.J., M.T.M., C.J., B.F., H.L., Y.H., F.K., P.E.B., W.R.W.), Bioengineering (B.F.M., E.H., S.K.I.), and Medicine (Y.H., P.B.), Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104.

Paco E Bravo (PE)

Departments of Radiology (N.J., M.T.M., C.J., B.F., H.L., Y.H., F.K., P.E.B., W.R.W.), Bioengineering (B.F.M., E.H., S.K.I.), and Medicine (Y.H., P.B.), Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104.

Walter R Witschey (WR)

Departments of Radiology (N.J., M.T.M., C.J., B.F., H.L., Y.H., F.K., P.E.B., W.R.W.), Bioengineering (B.F.M., E.H., S.K.I.), and Medicine (Y.H., P.B.), Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104.
ORCID: 0000-0003-1669-2120

Classifications MeSH