MAIT cell alterations in adults with recent-onset and long-term type 1 diabetes.
Adult
Aged
Antigens, CD
Antigens, Differentiation, T-Lymphocyte
Biomarkers
/ metabolism
Blood Donors
Cytokines
/ metabolism
Diabetes Mellitus, Type 1
/ metabolism
Female
Flow Cytometry
Humans
Interleukin-2 Receptor alpha Subunit
/ metabolism
Lectins, C-Type
Male
Middle Aged
Mucosal-Associated Invariant T Cells
/ metabolism
Phenotype
Programmed Cell Death 1 Receptor
/ metabolism
Proto-Oncogene Proteins c-bcl-2
Young Adult
Autoimmunity
Cytokine
Granzyme
Human
Innate immunity
MAIT cells
Type 1 diabetes
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
07
12
2020
accepted:
27
04
2021
pubmed:
6
8
2021
medline:
19
3
2022
entrez:
5
8
2021
Statut:
ppublish
Résumé
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes expressing an αβ T cell antigen receptor that recognises the MHC-related 1 molecule. MAIT cells are altered in children at risk for and with type 1 diabetes, and mouse model studies have shown MAIT cell involvement in type 1 diabetes development. Since several studies support heterogeneity in type 1 diabetes physiopathology according to the age of individuals, we investigated whether MAIT cells were altered in adults with type 1 diabetes. MAIT cell frequency, phenotype and function were analysed by flow cytometry, using fresh peripheral blood from 21 adults with recent-onset type 1 diabetes (2-14 days after disease onset) and 47 adults with long-term disease (>2 years after diagnosis) compared with 55 healthy blood donors. We also separately analysed 17 women with long-term type 1 diabetes and an associated autoimmune disease, compared with 30 healthy women and 27 women with long-term type 1 diabetes. MAIT cells from adults with recent-onset type 1 diabetes, compared with healthy adult donors, harboured a strongly activated phenotype indicated by an elevated CD25 Alterations in MAIT cell frequency, phenotype and function were more pronounced in adults with long-term type 1 diabetes compared with adults with recent-onset type 1 diabetes. There were several correlations between MAIT cell variables and clinical characteristics. Moreover, the presence of another autoimmune disease in women with long-term type 1 diabetes further exacerbated MAIT cell alterations. Our results suggest that MAIT cell alterations in adults with type 1 diabetes could be associated with two aspects of the disease: impaired glucose homeostasis; and autoimmunity.
Identifiants
pubmed: 34350463
doi: 10.1007/s00125-021-05527-y
pii: 10.1007/s00125-021-05527-y
pmc: PMC8336671
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, T-Lymphocyte
0
Biomarkers
0
CD69 antigen
0
Cytokines
0
IL2RA protein, human
0
Interleukin-2 Receptor alpha Subunit
0
Lectins, C-Type
0
PDCD1 protein, human
0
Programmed Cell Death 1 Receptor
0
Proto-Oncogene Proteins c-bcl-2
0
Banques de données
figshare
['10.6084/m9.figshare.c.5328767']
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2306-2321Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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