Experimental Intestinal Stenosis Alters Crohn's Disease-Like Intestinal Inflammation in Ileitis-Prone Mice.
Crohn’s disease animal model
Intestinal stenosis
Intraluminal pressure
Mechanical factors in Crohn’s
TNFDare mice
Journal
Digestive diseases and sciences
ISSN: 1573-2568
Titre abrégé: Dig Dis Sci
Pays: United States
ID NLM: 7902782
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
20
03
2021
accepted:
08
06
2021
pubmed:
6
8
2021
medline:
1
6
2022
entrez:
5
8
2021
Statut:
ppublish
Résumé
Clinical observations indicate that mechanical factors contribute to the expression or recurrence of Crohn's disease. We investigated whether the creation of an intestinal stenosis could alter the severity of the expected Crohn-like ileitis, in a Crohn's disease animal model, the TNF Thirty-six, 6-weeks-old TNF The triple suture stenosis induced significant muscular hypertrophy proximal to interventional site which was more prominent in TNF The creation of a stenosis in the terminal ileum of TNF
Sections du résumé
BACKGROUND
Clinical observations indicate that mechanical factors contribute to the expression or recurrence of Crohn's disease. We investigated whether the creation of an intestinal stenosis could alter the severity of the expected Crohn-like ileitis, in a Crohn's disease animal model, the TNF
METHODS
Thirty-six, 6-weeks-old TNF
RESULTS
The triple suture stenosis induced significant muscular hypertrophy proximal to interventional site which was more prominent in TNF
CONCLUSION
The creation of a stenosis in the terminal ileum of TNF
Identifiants
pubmed: 34350516
doi: 10.1007/s10620-021-07161-5
pii: 10.1007/s10620-021-07161-5
doi:
Substances chimiques
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1783-1793Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis: a pathologic and clinical entity. J Am Med Assoc. 1932;99:1323–1329.
doi: 10.1001/jama.1932.02740680019005
Gajendran M, Loganathan P, Catinella AP, Hashash JG. A comprehensive review and update on Crohn’s disease. Disease-a-Month. 2018;64:20–57. https://doi.org/10.1016/j.disamonth.2017.07.001 .
doi: 10.1016/j.disamonth.2017.07.001
pubmed: 28826742
Torres J, Mehandru S, Colombel JF, Peyrin-Biroulet L. Crohn’s disease. Lancet. 2017;389:1741–1755.
doi: 10.1016/S0140-6736(16)31711-1
Caprilli R. Why does Crohn ’ s disease usually occur in terminal ileum ? J Crohn’s Colitis 2008;2:352–366. https://doi.org/10.1016/j.crohns.2008.06.001 .
doi: 10.1016/j.crohns.2008.06.001
Pizarro TT, Arseneau KO, Bamias G, Cominelli F. Mouse models for the study of Crohn’s disease. Trends Mol Med. 2003;9:218–222.
doi: 10.1016/S1471-4914(03)00052-2
Cominelli F, Arseneau KO, Rodriguez-Palacios A, Pizarro TT. Uncovering pathogenic mechanisms of inflammatory bowel disease using mouse models of Crohn’s disease-like ileitis: what is the right model? Cell Mol Gastrenterol Hepatol 2017;4:19–32. https://doi.org/10.1016/j.jcmgh.2017.02.010 .
doi: 10.1016/j.jcmgh.2017.02.010
Mizoguchi A. Animal models of inflammatory bowel disease. In: Progress in molecular biology and translational science. Elsevier B.V.; 2012, pp 263–320.
Kontoyiannis D, Boulougouris G, Manoloukos M, Armaka M, Apostolaki M, Pizarro T et al. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor—induced Crohn ’ s-like Inflammatory bowel disease. J Exp Med. 2002;196:1563–1574.
doi: 10.1084/jem.20020281
Reynolds HL, Stellato TA. Crohn’s disease of the foregut. Surg Clin North Am. 2020;81:117–135.
doi: 10.1016/S0039-6109(05)70276-0
Gionchetti P, Dignass A, Danese S, Dias FJM, Rogler G, Lakatos PL et al. 3rd European evidence-based consensus on the diagnosis and management of Crohn’s disease 2016: part 2: Surgical management and special situations. J Crohn’s Colitis 2017;11:135–149.
doi: 10.1093/ecco-jcc/jjw169
Gklavas A, Dellaportas D, Papaconstantinou I. Risk factors for postoperative recurrence of crohn’s disease with emphasis on surgical predictors. Ann Gastroenterol. 2017;30:598–612.
pubmed: 29118554
pmcid: 5670279
Cima RR, Wolff BG. Reoperative Crohn ’ s surgery: tricks of the trade. Intest Res 2007;1:336–343.
Roulis M, Armaka M, Manoloukos M, Apostolaki M, Kollias G. Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology. Proc Natl Acad Sci USA 2011;108:5396–5401.
doi: 10.1073/pnas.1007811108
Strober W, Fuss I, Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Invest. 2007;117:514–521.
doi: 10.1172/JCI30587
Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, Kollias G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- rich elements: implications for joint and gut-associated immunopathologies. Immunity. 1999;10:387–398.
doi: 10.1016/S1074-7613(00)80038-2
Baur P, Martin F-P, Gruber L, Bosco N, Brahmbhatt V, Collino S et al. Metabolic phenotyping of the Crohn’s disease-like IBD etiopathology in the TNF ΔARE/WT mouse model. J Proteome Res. 2011;10:5523–5535.
doi: 10.1021/pr2007973
Gibson PR. Increased gut permeability in Crohn’s disease: is TNF the link ? Gut. 2004;53:1724–1729.
doi: 10.1136/gut.2004.047092
The European Parliament and the Council of the European Union. Directive 2010/63/EU of the European Paliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. Off J Eur Union. 2010;(276):33–79.
President of the Greek Republic. Presidential Decree 56/2013. Εφημερίδα Της Κυβερνήσεως. 2013;(53).
National Centre for the Refinement & Reduction of Animals in Research. The 3Rs | NC3Rs [Internet]. [cited 2021 Jan 31]. https://www.nc3rs.org.uk/the-3rs
Brito MVH, Yasojima EY, Teixeira RKC, de Houat AP, Yamaki VN, da Costa FLS. Fasting does not induce gastric emptying in rats. Acta Cir Bras 2015;30:165–169.
doi: 10.1590/S0102-865020150030000001
Ha SE, Wei L, Jorgensen BG, Lee MY, Park PJ, Poudrier SM et al. A mouse model of intestinal partial obstruction. J Vis Exp. 2018;133:1–7.
Berlin SC, Goske MJ, Obuchowski N, Alexander F, Zepp RC, Goldblum JR et al. Small bowel obstruction in rats: diagnostic accuracy of sonography versus radiography. J Ultrasound Med. 1998;17:497–504.
doi: 10.7863/jum.1998.17.8.497
Georgopoulos I, Mavrigiannaki E, Stasinopoulou S, Renieris G, Nikolakis G, Chaniotakis I et al. Experimental models of partial intestinal obstruction in young mice, establishment, and evaluation. J Surg Res 2020;252:206–215. https://doi.org/10.1016/j.jss.2020.03.007 .
doi: 10.1016/j.jss.2020.03.007
pubmed: 32283334
American Veterinary Medical Association. AVMA guidelines for the Euthanasia of Animals: 2013 Edition [Internet]. 2013. https://www.avma.org/kb/policies/documents/euthanasia.pdf . (January 2018)
National Research Council of the National Academies. Guide for the care and use of laboratory animals [Internet]. 2011. http://www.ncbi.nlm.nih.gov/pubmed/21595115
Katakura K, Lee J, Rachmilewitz D, Li G, Eckmann L, Raz E. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest. 2005;115:695–702.
doi: 10.1172/JCI22996
Dutta S, Sengupta P. Men and mice: relating their ages. Life Sci 2016;152:244–288. https://doi.org/10.1016/j.lfs.2015.10.025 .
doi: 10.1016/j.lfs.2015.10.025
pubmed: 26596563
Velazco C, McMachon L, Ostlie D. Inflammatory bowel disease. In: Holcomb GW, Murphy JP, StPeter SD, Gatti JM, eds. 7th edn. Amsterdam: Elsevier; 2019; 647–663.
Holvoet T, Devriese S, Castermans K, Boland S, Leysen D, Vandewynckel Y-P et al. Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local rho kinase inhibitor. Gastroenterology 2017;153:1054–1067.
doi: 10.1053/j.gastro.2017.06.013
Rieder F, Kessler S, Sans M, Fiocchi C. Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease. Am J Physiol Gastrointest Liver Physiol 2012;303:G786–G801.
doi: 10.1152/ajpgi.00059.2012
Chen W, Lu C, Hirota C, Iacucci M, Ghosh S, Gui X. Smooth muscle hyperplasia/hypertrophy is the most prominent histological change in Crohn’s fibrostenosing bowel strictures: a semiquantitative analysis by using a novel histological grading scheme. J Crohn’s Colitis 2017;11:92–104.
doi: 10.1093/ecco-jcc/jjw126
Pizarro TT, Pastorelli L, Bamias G, Garg RR, Reuter BK, Mercado JR et al. The SAMP1/YitFc mouse strain: a spontaneous model of Crohn’s disease-like ileitis. Inflamm Bowel Dis 2011;17:2566–2584.
doi: 10.1002/ibd.21638
Zhao J, Liao D, Yang J, Gregersen H. Phasic and tonic smooth muscle function of the partially obstructed guinea pig intestine. J Biomed Biotechnol. 2011;2011:1–9.
Gabella G. Hypertrophy of intestinal smooth muscle. Cell Tissue Res. 1975;163:199–214.
doi: 10.1007/BF00221727
Nair DG, Miller KG, Lourenssen SR, Blennerhassett MG. Inflammatory cytokines promote growth of intestinal smooth muscle cells by induced expression of PDGF-Rβ. J Cell Mol Med. 2014;18:444–454.
doi: 10.1111/jcmm.12193
Nair DG, Han TY, Lourenssen S, Blennerhassett MG. Proliferation modulates intestinal smooth muscle phenotype in vitro and in colitis in vivo. Am J Physiol Gastrointest Liver Physiol. 2011;300:903–913.
doi: 10.1152/ajpgi.00528.2010
Arrieta MC, Bistritz L, Meddings JB. Alterations in intestinal permeability. Gut 2006;55:1512–1520.
doi: 10.1136/gut.2005.085373
Roulis M, Bongers G, Armaka M, Salviano T, He Z, Singh A et al. Host and microbiota interactions are critical for development of murine Crohn’s-like ileitis. Mucosal Immunol. 2016;9:787–797.
doi: 10.1038/mi.2015.102
Schaubeck M, Clavel T, Calasan J, Lagkouvardos I, Haange SB, Jehmlich N et al. Dysbiotic gut microbiota causes transmissible Crohn’s disease-like ileitis independent of failure in antimicrobial defence. Gut. 2016;65:225–237.
doi: 10.1136/gutjnl-2015-309333
Dinning PG, Bampton PA, Kennedy ML, Kajimoto T, Lubowski DZ, Carle DJDE et al. Basal pressure patterns and reflexive motor responses in the human ileocolonic junction. Am J Physiol 1999;276:G331–G340.
pubmed: 9950806
Quigley EMM, Borody TJ, Phillips SF, Wienbeck M, Tucker RL, Haddad A. Motility of the terminal ileum and ileocecal sphincter in healthy humans. Gastroenterology 1984;87:857–866. https://doi.org/10.1016/0016-5085(84)90080-5 .
doi: 10.1016/0016-5085(84)90080-5
pubmed: 6468873
Baker WNW, Mann CV. The rectosigmoid junction zone: another sphincter? In: Alimentary sphincters and their disorders. London: Palgrave Macmillan UK; 1981, pp 201–11. https://doi.org/10.1007/978-1-349-03940-1_9
Hill JR, Kelley ML, Schlegel JF, Code CF. Pressure profile of the rectum and anus of healthy persons. Dis Colon Rectum 1960;3:203–209.
doi: 10.1007/BF02616555
Enochsson L, Nylander G, Öhman U. Effects of intraluminal pressure on regional blood flow in obstructed and unobstructed small intestines in the rat. Am J Surg 1982;144:558–561.
doi: 10.1016/0002-9610(82)90580-3
Hörmannsperger G, Schaubeck M, Haller D. Intestinal microbiota in animal models of inflammatory diseases. ILAR J. 2015;56:179–191.
doi: 10.1093/ilar/ilv019
Kastl AJ, Terry NA, Wu GD, Albenberg LG. The structure and function of the human small intestinal microbiota: current understanding and future directions. Cmgh 2009;9:33–45. https://doi.org/10.1016/j.jcmgh.2019.07.006 .
doi: 10.1016/j.jcmgh.2019.07.006