Acute localized exanthematous pustulosis: Clinical features, pathophysiology, and therapy.
acute generalized exanthematous pustulosis
acute localized exanthematous pustulosis
cutaneous drug reaction
pustule
Journal
Dermatologic therapy
ISSN: 1529-8019
Titre abrégé: Dermatol Ther
Pays: United States
ID NLM: 9700070
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
29
07
2021
received:
11
11
2020
accepted:
02
08
2021
pubmed:
6
8
2021
medline:
3
11
2021
entrez:
5
8
2021
Statut:
ppublish
Résumé
Acute localized exanthematous pustulosis (ALEP) is a rare disease characterized by the acute onset of multiple localized non-follicular, pinhead-sized pustules. ALEP is considered a localized form of acute generalized exanthematous pustulosis but its pathogeny is not well identified. We performed a systematic review of the literature of all publications regarding ALEP cases using the term "acute localized exanthematous pustulosis," to provide an update on this disease and its management. Results and conclusion ALEP is an uncommon skin condition attributed primarily to a hypersensitivity reaction to a systemic drug (classical or herbal); though a contact mechanism has been reported. It may be misdiagnosed as infectious or inflammatory disease but the clinico-pathological correlation in addition to the rapid response to withdrawal of the culprit agent supports this diagnosis. The pathogenesis of ALEP is still unclear, and there are no standardized treatment guidelines to manage this disease. Both AGEP and ALEP have a good prognosis if an early diagnosis is made.
Types de publication
Journal Article
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15087Informations de copyright
© 2021 Wiley Periodicals LLC.
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