Hippocampal volume reduction is associated with direct measure of insulin resistance in adults.
Adiposity
Hippocampal volume
Insulin resistance
Journal
Neuroscience research
ISSN: 1872-8111
Titre abrégé: Neurosci Res
Pays: Ireland
ID NLM: 8500749
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
30
03
2021
revised:
16
07
2021
accepted:
28
07
2021
pubmed:
6
8
2021
medline:
11
1
2022
entrez:
5
8
2021
Statut:
ppublish
Résumé
Hippocampal integrity is highly susceptible to metabolic dysfunction, yet its mechanisms are not well defined. We studied 126 healthy individuals aged 23-61 years. Insulin resistance (IR) was quantified by measuring steady-state plasma glucose (SSPG) concentration during the insulin suppression test. Body mass index (BMI), adiposity, fasting insulin, glucose, leptin as well as structural neuroimaing with automatic hippocampal subfield segmentation were performed. Data analysis using unsupervised machine learning (k-means clustering) identified two subgroups reflecting a pattern of more pronounced hippocampal volume reduction being concurrently associated with greater adiposity and insulin resistance; the hippocampal volume reductions were uniform across subfields. Individuals in the most deviant subgroup were predominantly women (79 versus 42 %) with higher BMI [27.9 (2.5) versus 30.5 (4.6) kg/m
Identifiants
pubmed: 34352294
pii: S0168-0102(21)00176-0
doi: 10.1016/j.neures.2021.07.006
pmc: PMC9164143
mid: NIHMS1783621
pii:
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-24Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK116074
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG050345
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
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