Systems modeling of metabolic dysregulation in neurodegenerative diseases.
Neurodegenerative diseases, Metabolic modeling, Multiomics analysis, Network approaches
Journal
Current opinion in pharmacology
ISSN: 1471-4973
Titre abrégé: Curr Opin Pharmacol
Pays: England
ID NLM: 100966133
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
25
05
2021
accepted:
28
06
2021
pubmed:
6
8
2021
medline:
9
11
2021
entrez:
5
8
2021
Statut:
ppublish
Résumé
Neurodegenerative diseases (NDDs) encompass a wide range of conditions that arise owing to progressive degeneration and the ultimate loss of nerve cells in the brain and peripheral nervous system. NDDs such as Alzheimer's, Parkinson's, and Huntington's diseases negatively impact both length and quality of life, due to lack of effective disease-modifying treatments. Herein, we review the use of genome-scale metabolic models, network-based approaches, and integration with multiomics data to identify key biological processes that characterize NDDs. We describe powerful systems biology approaches for modeling NDD pathophysiology by leveraging in silico models that are informed by patient-derived multiomics data. These approaches can enable mechanistic insights into NDD-specific metabolic dysregulations that can be leveraged to identify potential metabolic markers of disease and predisease states.
Identifiants
pubmed: 34352486
pii: S1471-4892(21)00085-0
doi: 10.1016/j.coph.2021.06.012
pmc: PMC8511060
mid: NIHMS1729964
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-65Subventions
Organisme : NIA NIH HHS
ID : RF1 AG058469
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG061835
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG063068
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG059319
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061796
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG046139
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG061359
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062514
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057452
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest statement Nothing declared.
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