Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study.
diabetes mellitus
epidemiology
longitudinal studies
muscles
type 2
Journal
BMJ open diabetes research & care
ISSN: 2052-4897
Titre abrégé: BMJ Open Diabetes Res Care
Pays: England
ID NLM: 101641391
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
26
08
2020
accepted:
24
01
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
12
8
2021
Statut:
ppublish
Résumé
Grip strength has been associated with chronic diseases and mortality. However, current evidence of the association between grip strength and incident type 2 diabetes mellitus (T2DM) is controversial. The aim of this study was to investigate the associations of absolute and relative grip strength with incident T2DM and whether these associations differ by sociodemographic, lifestyle and adiposity-related factors. This was a prospective cohort study of 166 894 participants in the UK Biobank (mean age 56.5 years, 54.4% women). The outcome was T2DM incidence and the exposure was grip strength, expressed in absolute (kg) and relative (kg per kg of body weight) values. The association between grip strength and T2DM incidence was investigated using Cox-proportional regression. The median follow-up was 5.3 years (IQR: 4.7-6.1). During this time, 3713 participants developed T2DM. Lower grip strength was associated with a higher risk of T2DM in both sexes. Those in the lowest quintile of absolute grip strength had a 50% higher risk in men (HR: 1.50 (95% CI: 1.30 to 1.73)) and 25% higher risk in women (HR: 1.25 (95% CI: 1.06 to 1.47)) compared with those in the highest quintile. For relative grip strength, risk of diabetes was more than double for men (HR: 2.22 (95% CI: 1.84 to 2.67)) and 96% higher for women (HR: 1.96 (95% CI: 1.52 to 2.53)) in the lowest compared with highest quintiles. Grip strength is associated with a higher risk of T2DM incidence in both men and women independent of important confounding factors including age, deprivation, adiposity and lifestyle. However, the associations were stronger when grip strength is expressed relative to body weight, which could reflect the importance of muscle quality.
Identifiants
pubmed: 34353878
pii: 9/1/e001865
doi: 10.1136/bmjdrc-2020-001865
pmc: PMC8344322
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL125442
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
BMJ. 2018 May 8;361:k1651
pubmed: 29739772
Int J Epidemiol. 2016 Feb;45(1):278-84
pubmed: 26675753
Curr Opin Clin Nutr Metab Care. 2015 Sep;18(5):465-70
pubmed: 26147527
Metabolism. 2016 Jun;65(6):883-92
pubmed: 27173467
Mayo Clin Proc. 2020 May;95(5):879-888
pubmed: 32299669
World Health Organ Tech Rep Ser. 1995;854:1-452
pubmed: 8594834
J Clin Endocrinol Metab. 2016 Apr;101(4):1847-55
pubmed: 26930180
Eur Heart J. 2017 Jan 7;38(2):116-122
pubmed: 28158566
Lancet Public Health. 2018 Dec;3(12):e576-e585
pubmed: 30467019
BMJ Open Diabetes Res Care. 2019 Dec 17;7(1):e000765
pubmed: 31908795
Diabet Med. 2018 Feb;35(2):270-276
pubmed: 29171078
BMC Med. 2018 May 24;16(1):77
pubmed: 29792209
Age Ageing. 2011 Jul;40(4):423-9
pubmed: 21624928
N Engl J Med. 2017 Apr 13;376(15):1407-1418
pubmed: 28402770
BMJ. 2010 Sep 09;341:c4467
pubmed: 20829298
Diabet Med. 2017 Aug;34(8):1120-1128
pubmed: 28144980
Diabetes Care. 2017 Dec;40(12):1710-1718
pubmed: 28986505
Nat Commun. 2017 Jul 12;8:16015
pubmed: 29313844
Lancet. 2015 Jul 18;386(9990):266-73
pubmed: 25982160
Am J Prev Med. 2020 Jun;58(6):757-765
pubmed: 32273132
Age Ageing. 2019 Sep 1;48(5):684-691
pubmed: 31204772
Am J Epidemiol. 2017 Nov 1;186(9):1026-1034
pubmed: 28641372
Eur J Epidemiol. 2015 Jul;30(7):529-42
pubmed: 26092138
Age Ageing. 2018 Sep 1;47(5):685-691
pubmed: 29726885
Rejuvenation Res. 2019 Jun;22(3):230-234
pubmed: 30200809
PLoS Med. 2015 Mar 31;12(3):e1001779
pubmed: 25826379
Mayo Clin Proc. 2019 Apr;94(4):643-651
pubmed: 30871784
Lancet. 2007 Jun 16;369(9578):1980-1982
pubmed: 17574079
Diabetologia. 2019 Jul;62(7):1129-1142
pubmed: 31011778
Diabetes Res Clin Pract. 2011 May;92(2):261-4
pubmed: 21281974
Lancet. 2012 Mar 31;379(9822):1173-4
pubmed: 22463865