Prevalence and genetic characteristics of Blastocystis hominis and Cystoisospora belli in HIV/AIDS patients in Guangxi Zhuang Autonomous Region, China.
Acquired Immunodeficiency Syndrome
/ complications
Adult
Blastocystis
/ genetics
Blastocystis Infections
/ epidemiology
Blastocystis hominis
/ genetics
China
/ epidemiology
DNA, Protozoan
/ genetics
Feces
/ parasitology
Female
Genetic Variation
/ genetics
Genotype
HIV-1
/ pathogenicity
Humans
Isospora
/ genetics
Isosporiasis
/ epidemiology
Male
Middle Aged
Prevalence
Risk Factors
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 08 2021
05 08 2021
Historique:
received:
15
01
2021
accepted:
06
07
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Blastocystis hominis and Cystoisospora belli are considered to be common opportunistic intestinal protozoa in HIV/AIDS patients. In order to investigate the prevalence and genetic characteristics of B. hominis and C. belli in HIV/AIDS patients, a total of 285 faecal samples were individually collected from HIV/AIDS patients in Guangxi, China. B. hominis and C. belli were investigated by amplifying the barcode region of the SSU rRNA gene and the internal transcribed spacer 1 (ITS-1) region of the rRNA gene, respectively. Chi-square test or Fisher's exact test were conducted to assess the risk factors related to B. hominis and C. belli infection. The prevalence of B. hominis and C. belli was 6.0% (17/285) and 1.1% (3/285) respectively. Four genotypes of B. hominis were detected, with ST3 (n = 8) and ST1 (n = 6) being predominant, followed by ST6 (n = 2) and ST7 (n = 1). Females had a statistically higher prevalence of B. hominis (11.6%) than males (4.2%). The statistical analysis also showed that the prevalence of B. hominis was significantly associated with age group and educational level. Our study provides convincing evidence for the genetic diversity of B. hominis, which indicates its potential zoonotic transmission and is the first report on the molecular characteristics of C. belli in HIV/AIDS patients in China.
Identifiants
pubmed: 34354101
doi: 10.1038/s41598-021-94962-3
pii: 10.1038/s41598-021-94962-3
pmc: PMC8342556
doi:
Substances chimiques
DNA, Protozoan
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15904Informations de copyright
© 2021. The Author(s).
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