Survival Benefits and Disparities in Adjuvant Radiation Therapy for Patients with Pancreatic Cancer.
Pancreas cancer
Pancreatic neoplasms
Radiation
Radiosurgery
Radiotherapy
Stereotactic
Stereotactic body radiation therapy (SBRT)
Journal
JOP : Journal of the pancreas
ISSN: 1590-8577
Titre abrégé: JOP
Pays: Italy
ID NLM: 101091810
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
7
8
2021
Statut:
ppublish
Résumé
The effects of adjuvant radiation therapy on pancreatic cancer outcomes after resection are not well defined in the literature. We abstracted data from the Surveillance, Epidemiology, and End Result (SEER) database to explore the impact of adjuvant radiation on cancer-specific survival in pancreatic cancer patients who received surgical resection. A total of 10,224 patients met our inclusion criteria with 6768 (66.2%) patients treated with surgery only and 3456 (33.8%) treated with surgery plus adjuvant radiation. Surgery followed by adjuvant radiation was associated with significantly improved survival (HR: 0.753, CI: 0.718-0.789, p<0.001). Additionally, female gender and married status were both independently associated with better survival (p<0.05), while advanced age, Caucasian race, higher TNM stage, and higher grade had worse survival outcomes (p<0.05) Asian and Spanish-Hispanic-Latino patients were less likely to receive adjuvant radiotherapy (p<0.05). Adjuvant radiation was associated with significantly improved survival after resection for pancreatic cancer. There are significant differences in the patient populations who receive adjuvant radiation.
Sections du résumé
BACKGROUND
BACKGROUND
The effects of adjuvant radiation therapy on pancreatic cancer outcomes after resection are not well defined in the literature.
METHODS
METHODS
We abstracted data from the Surveillance, Epidemiology, and End Result (SEER) database to explore the impact of adjuvant radiation on cancer-specific survival in pancreatic cancer patients who received surgical resection.
RESULTS
RESULTS
A total of 10,224 patients met our inclusion criteria with 6768 (66.2%) patients treated with surgery only and 3456 (33.8%) treated with surgery plus adjuvant radiation. Surgery followed by adjuvant radiation was associated with significantly improved survival (HR: 0.753, CI: 0.718-0.789, p<0.001). Additionally, female gender and married status were both independently associated with better survival (p<0.05), while advanced age, Caucasian race, higher TNM stage, and higher grade had worse survival outcomes (p<0.05) Asian and Spanish-Hispanic-Latino patients were less likely to receive adjuvant radiotherapy (p<0.05).
CONCLUSION
CONCLUSIONS
Adjuvant radiation was associated with significantly improved survival after resection for pancreatic cancer. There are significant differences in the patient populations who receive adjuvant radiation.
Types de publication
Journal Article
Langues
eng
Pagination
36-41Subventions
Organisme : NCI NIH HHS
ID : UG1 CA189850
Pays : United States
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