Preoperative imaging of glioblastoma patients using hyperpolarized
bicarbonate
glioblastoma
hyperpolarized
preoperative
pyruvate
Journal
Neuro-oncology advances
ISSN: 2632-2498
Titre abrégé: Neurooncol Adv
Pays: England
ID NLM: 101755003
Informations de publication
Date de publication:
Historique:
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
7
8
2021
Statut:
epublish
Résumé
Glioblastoma remains incurable despite treatment with surgery, radiation therapy, and cytotoxic chemotherapy, prompting the search for a metabolic pathway unique to glioblastoma cells. Three patients with diagnostic MRI suggestive of a glioblastoma were scanned at 3 T 1-2 days prior to tumor resection using a Each tumor was histologically confirmed to be a WHO grade IV glioblastoma with isocitrate dehydrogenase wild type. Total hyperpolarized Prior to surgical resection,
Sections du résumé
BACKGROUND
BACKGROUND
Glioblastoma remains incurable despite treatment with surgery, radiation therapy, and cytotoxic chemotherapy, prompting the search for a metabolic pathway unique to glioblastoma cells.
METHODS
METHODS
Three patients with diagnostic MRI suggestive of a glioblastoma were scanned at 3 T 1-2 days prior to tumor resection using a
RESULTS
RESULTS
Each tumor was histologically confirmed to be a WHO grade IV glioblastoma with isocitrate dehydrogenase wild type. Total hyperpolarized
CONCLUSIONS
CONCLUSIONS
Prior to surgical resection,
Identifiants
pubmed: 34355174
doi: 10.1093/noajnl/vdab092
pii: vdab092
pmc: PMC8331053
doi:
Types de publication
Journal Article
Langues
eng
Pagination
vdab092Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB015908
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107409
Pays : United States
Organisme : NIH HHS
ID : S10 OD018468
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.
Références
J Neurosurg Sci. 2018 Dec;62(6):682-689
pubmed: 29671296
Neuroimage Clin. 2020;27:102323
pubmed: 32623139
Cell Metab. 2012 Jun 6;15(6):827-37
pubmed: 22682223
J Neurol Surg A Cent Eur Neurosurg. 2018 Jul;79(4):330-336
pubmed: 29684925
Circ Res. 2020 Dec 4;127(12):1568-1570
pubmed: 33054563
Circ Res. 2016 Nov 11;119(11):1177-1182
pubmed: 27635086
NMR Biomed. 2012 Nov;25(11):1234-44
pubmed: 22419606
PLoS One. 2017 Jan 19;12(1):e0169292
pubmed: 28103256
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10158-63
pubmed: 12930897
Neuroimage. 2019 Apr 1;189:171-179
pubmed: 30639333
Cancer Res. 2018 Jul 15;78(14):3755-3760
pubmed: 29769199
NMR Biomed. 2016 May;29(5):650-9
pubmed: 26990457
J Magn Reson Imaging. 2011 Jun;33(6):1284-90
pubmed: 21590996
J Neurosurg Sci. 2019 Dec;63(6):625-632
pubmed: 31355623
Curr Treat Options Neurol. 2014 Apr;16(4):284
pubmed: 24595756
Neuro Oncol. 2013 Apr;15(4):433-41
pubmed: 23328814
Neuro Oncol. 2012 Mar;14(3):315-25
pubmed: 22156546
Neuro Oncol. 2010 Feb;12(2):133-44
pubmed: 20150380
Magn Reson Med. 2011 Feb;65(2):557-63
pubmed: 21264939
IEEE Trans Med Imaging. 2020 Feb;39(2):320-327
pubmed: 31283497
Magn Reson Med. 2019 Apr;81(4):2702-2709
pubmed: 30375043
iScience. 2020 Nov 30;23(12):101885
pubmed: 33344923
Neuroimage. 2012 Jan 2;59(1):193-201
pubmed: 21807103
Cell. 2014 Dec 18;159(7):1603-14
pubmed: 25525878
Magn Reson Med. 1993 Dec;30(6):672-9
pubmed: 8139448
NMR Biomed. 2019 Feb;32(2):e4044
pubmed: 30561869
Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11270-5
pubmed: 16837573
Nat Med. 2012 Jan 26;18(4):624-9
pubmed: 22281806
PLoS One. 2019 Dec 12;14(12):e0225313
pubmed: 31830049
N Engl J Med. 2005 Mar 10;352(10):987-96
pubmed: 15758009