Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram.
Journal
RSC medicinal chemistry
ISSN: 2632-8682
Titre abrégé: RSC Med Chem
Pays: England
ID NLM: 101759460
Informations de publication
Date de publication:
21 Jul 2021
21 Jul 2021
Historique:
received:
06
03
2021
accepted:
27
05
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
7
8
2021
Statut:
epublish
Résumé
The utilization of fluorescent ligands to study the monoamine transporters (MATs) has increased our knowledge of their function and distribution in live cell systems. In this study, we extend SAR for nisoxetine and talopram as parent compounds, to identify high affinity rhodamine-labeled fluorescent probes for the norepinephrine transporter (NET). Nisoxetine-based fluorescent probe
Identifiants
pubmed: 34355183
doi: 10.1039/d1md00072a
pii: d1md00072a
pmc: PMC8292982
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1174-1186Subventions
Organisme : Intramural NIH HHS
ID : ZIA DA000610
Pays : United States
Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There is no conflict of interest to declare.
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