Is ABO-Incompatible Living Donor Liver Transplantation Really a Good Alternative for Pediatric Recipients?
ABO incompatibility
C4d immunostaining
acute humoral rejection
biliary complications
pediatric liver transplantation
Journal
Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936
Informations de publication
Date de publication:
16 Jul 2021
16 Jul 2021
Historique:
received:
21
05
2021
revised:
21
06
2021
accepted:
14
07
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
7
8
2021
Statut:
epublish
Résumé
ABO-incompatible (ABOi) living donor liver transplantation (LDLT) has been proposed to compensate for donor shortage. To date, few studies have reported detailed ABOi LDLT results in large series of pediatric patients. C4d complement deposition in graft capillaries has been reported to be associated with antibody-mediated rejection in solid organ transplantation. A retrospective case-control study was conducted, comparing clinical outcomes of each of 34 consecutive pediatric ABOi LDLT recipients with those of 2 non-ABOi pairs ( The incidence of biliary complications was higher in ABOi recipients ( ABOi LDLT is a feasible option for pediatric end-stage liver disease but carries increased risks for the recipient, especially for children older than 1 year, even with a specific preparation protocol. C4d immunostaining may be a hallmark of acute humoral rejection in ABOi liver transplantation.
Sections du résumé
BACKGROUND
BACKGROUND
ABO-incompatible (ABOi) living donor liver transplantation (LDLT) has been proposed to compensate for donor shortage. To date, few studies have reported detailed ABOi LDLT results in large series of pediatric patients. C4d complement deposition in graft capillaries has been reported to be associated with antibody-mediated rejection in solid organ transplantation.
METHODS
METHODS
A retrospective case-control study was conducted, comparing clinical outcomes of each of 34 consecutive pediatric ABOi LDLT recipients with those of 2 non-ABOi pairs (
RESULTS
RESULTS
The incidence of biliary complications was higher in ABOi recipients (
CONCLUSIONS
CONCLUSIONS
ABOi LDLT is a feasible option for pediatric end-stage liver disease but carries increased risks for the recipient, especially for children older than 1 year, even with a specific preparation protocol. C4d immunostaining may be a hallmark of acute humoral rejection in ABOi liver transplantation.
Identifiants
pubmed: 34356579
pii: children8070600
doi: 10.3390/children8070600
pmc: PMC8303569
pii:
doi:
Types de publication
Journal Article
Langues
eng
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