Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma.
MCOLN
MITF
TFEB
TPC
TPC1
TPC2
TRPML
TRPML1
calcium
lysosome
mTOR
melanocytes
melanoma
mucolipin
two-pore
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
13 07 2021
13 07 2021
Historique:
received:
16
06
2021
revised:
08
07
2021
accepted:
12
07
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
7
10
2021
Statut:
epublish
Résumé
Microphthalmia-associated transcription factor (MITF) is the principal transcription factor regulating pivotal processes in melanoma cell development, growth, survival, proliferation, differentiation and invasion. In recent years, convincing evidence has been provided attesting key roles of endolysosomal cation channels, specifically TPCs and TRPMLs, in cancer, including breast cancer, glioblastoma, bladder cancer, hepatocellular carcinoma and melanoma. In this review, we provide a gene expression profile of these channels in different types of cancers and decipher their roles, in particular the roles of two-pore channel 2 (TPC2) and TRPML1 in melanocytes and melanoma. We specifically discuss the signaling cascades regulating MITF and the relationship between endolysosomal cation channels, MAPK, canonical Wnt/GSK3 pathways and MITF.
Identifiants
pubmed: 34356645
pii: biom11071021
doi: 10.3390/biom11071021
pmc: PMC8301777
pii:
doi:
Substances chimiques
Calcium Channels
0
Ion Channels
0
MCOLN1 protein, human
0
MITF protein, human
0
Microphthalmia-Associated Transcription Factor
0
TPCN2 protein, human
0
Transient Receptor Potential Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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