Epithelial Protein Lost in Neoplasm, EPLIN, the Cellular and Molecular Prospects in Cancers.
EPLIN
cancer progression
interactive partners
molecular signalling
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
16 07 2021
16 07 2021
Historique:
received:
07
06
2021
revised:
11
07
2021
accepted:
13
07
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
2
10
2021
Statut:
epublish
Résumé
Epithelial Protein Lost In Neoplasm (EPLIN), also known as LIMA1 (LIM Domain And Actin Binding 1), was first discovered as a protein differentially expressed in normal and cancerous cell lines. It is now known to be key to the progression and metastasis of certain solid tumours. Despite a slow pace in understanding the biological role in cells and body systems, as well as its clinical implications in the early years since its discovery, recent years have witnessed a rapid progress in understanding the mechanisms of this protein in cells, diseases and indeed the body. EPLIN has drawn more attention over the past few years with its roles expanding from cell migration and cytoskeletal dynamics, to cell cycle, gene regulation, angiogenesis/lymphangiogenesis and lipid metabolism. This concise review summarises and discusses the recent progress in understanding EPLIN in biological processes and its implications in cancer.
Identifiants
pubmed: 34356662
pii: biom11071038
doi: 10.3390/biom11071038
pmc: PMC8301816
pii:
doi:
Substances chimiques
Cytoskeletal Proteins
0
LIMA1 protein, human
0
MicroRNAs
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Biol Chem. 2013 Jan 18;288(3):1469-79
pubmed: 23188829
Science. 2018 Jun 8;360(6393):1087-1092
pubmed: 29880681
Int J Oncol. 2016 Jun;48(6):2488-96
pubmed: 27035883
Kidney Int. 2014 Sep;86(3):548-57
pubmed: 24694988
Mol Cell Biol. 2007 Dec;27(23):8190-204
pubmed: 17875928
Anticancer Res. 2019 Oct;39(10):5311-5327
pubmed: 31570425
Oncogene. 2011 Dec 15;30(50):4941-52
pubmed: 21625216
J Oncol. 2019 Sep 19;2019:7407190
pubmed: 31641356
J Cell Biol. 2020 Jul 6;219(7):
pubmed: 32496561
Mol Biol Cell. 2002 Apr;13(4):1408-16
pubmed: 11950948
World J Gastroenterol. 2015 Jan 7;21(1):84-93
pubmed: 25574081
Cells. 2020 Feb 29;9(3):
pubmed: 32121325
Oncogene. 1998 Apr 16;16(15):1921-30
pubmed: 9591775
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2327-E2336
pubmed: 28270608
Cell Cycle. 2016;15(5):628-43
pubmed: 27104745
Cell Rep. 2019 Oct 22;29(4):1010-1026.e6
pubmed: 31644899
Proc Natl Acad Sci U S A. 2017 May 16;114(20):5201-5206
pubmed: 28465438
J Urol. 2011 Jul;186(1):295-301
pubmed: 21600601
Cancer Cell. 2013 Oct 14;24(4):512-27
pubmed: 24135282
Cancer Metastasis Rev. 2015 Dec;34(4):753-64
pubmed: 26350886
Nat Commun. 2014 Jul 31;5:4428
pubmed: 25079702
Sci Rep. 2018 Feb 1;8(1):2097
pubmed: 29391412
Atherosclerosis. 2014 Dec;237(2):609-17
pubmed: 25463095
Hum Mol Genet. 2014 Jun 1;23(11):2847-57
pubmed: 24403050
Cancer Lett. 2017 Apr 1;390:58-66
pubmed: 28093207
J Pathol. 2017 Jan;241(2):294-309
pubmed: 27859258
Biomolecules. 2021 Apr 08;11(4):
pubmed: 33917939
Physiol Rev. 2004 Oct;84(4):1315-39
pubmed: 15383653
Genes Dis. 2017 Apr 01;4(2):100-107
pubmed: 30258911
Small GTPases. 2014;5(1):e28195
pubmed: 25763873
Nat Cell Biol. 2004 Feb;6(2):154-61
pubmed: 14743221
Angiogenesis. 2010 Dec;13(4):317-26
pubmed: 20848180
Biochemistry. 2019 Nov 26;58(47):4737-4743
pubmed: 30990684
J Cell Biol. 2003 Feb 3;160(3):399-407
pubmed: 12566430
Sci Rep. 2017 Mar 10;7:44328
pubmed: 28281696
J Biol Chem. 2012 Mar 2;287(10):7556-72
pubmed: 22194609
Circ Res. 2007 Feb 2;100(2):174-90
pubmed: 17272819
Cell. 2015 Dec 3;163(6):1484-99
pubmed: 26638075
Oncol Rep. 2006 Oct;16(4):747-54
pubmed: 16969489
Cell Cycle. 2009 Mar 1;8(5):757-64
pubmed: 19221476
J Cell Sci. 2015 Feb 15;128(4):781-9
pubmed: 25609711
Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):13-9
pubmed: 18093941
Anticancer Res. 2012 Apr;32(4):1283-9
pubmed: 22493360
Int J Cancer. 2018 Nov 15;143(10):2537-2550
pubmed: 30098000
Oncogene. 1999 Dec 16;18(54):7838-41
pubmed: 10618726
Mol Cancer. 2008 Sep 16;7:71
pubmed: 18796137
Oncotarget. 2017 Nov 6;8(63):107033-107043
pubmed: 29291009
J Cell Sci. 2019 Jan 3;132(1):
pubmed: 30606730
Gene. 2000 May 2;248(1-2):69-76
pubmed: 10806352
Proc Natl Acad Sci U S A. 1990 Jan;87(2):558-62
pubmed: 2105487