Deep-Sea Coral Garden Invertebrates and Their Associated Fungi Are Genetic Resources for Chronic Disease Drug Discovery.
High-throughput screening
anti-inflammatory
hMSC
marine fungi
natural products
osteoarthritis
osteoporosis
regenerative medicine
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
13 Jul 2021
13 Jul 2021
Historique:
received:
02
06
2021
revised:
05
07
2021
accepted:
09
07
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Chronic diseases characterized by bone and cartilage loss are associated with a reduced ability of progenitor cells to regenerate new tissues in an inflammatory environment. A promising strategy to treat such diseases is based on tissue repair mediated by human mesenchymal stem cells (hMSCs), but therapeutic outcomes are hindered by the absence of small molecules to efficiently modulate cell behaviour. Here, we applied a high-throughput drug screening technology to bioprospect a large library of extracts from Irish deep-sea organisms to induce hMSC differentiation toward musculoskeletal lineages and reduce inflammation of activated macrophages. The library included extracts from deep-sea corals, sponges and filamentous fungi representing a novel source of compounds for the targeted bioactivity. A validated hit rate of 3.4% was recorded from the invertebrate library, with cold water sea pens (octocoral order Pennatulacea), such as
Identifiants
pubmed: 34356815
pii: md19070390
doi: 10.3390/md19070390
pmc: PMC8303266
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Science Foundation Ireland
ID : 09/SRC/B1794
Pays : Ireland
Organisme : Science Foundation Ireland
ID : SFI/15/IA/3100
Pays : Ireland
Organisme : Irish Research Council
ID : GOIPG/2016/1113
Organisme : Fulbright Commission Ireland
ID : PM2020
Organisme : College of Medicine Nursing and 527 Health Sciences at NUI Galway
ID : PM2020
Organisme : Irish Government's Pro- 530 gramme for Research in Third Level Institutions
ID : Cycles 4 and 5
Organisme : Marine Institute and the European Regional Development Fund
ID : 2014-2020
Références
Nature. 2001 Feb 22;409(6823):1092-101
pubmed: 11234023
PLoS One. 2011;6(10):e26678
pubmed: 22046332
Stem Cells. 2016 Apr;34(4):913-23
pubmed: 26840742
Clin Orthop Relat Res. 2004 Oct;(427 Suppl):S27-36
pubmed: 15480070
Life Sci. 2009 Feb 27;84(9-10):290-5
pubmed: 19162043
Nat Prod Commun. 2009 Dec;4(12):1717-28
pubmed: 20120114
Int J Artif Organs. 2011 Oct;34(10):998-1011
pubmed: 22161283
Curr Drug Targets. 2007 Feb;8(2):283-92
pubmed: 17305506
J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 2):S151-8
pubmed: 11314793
Cell. 2007 Oct 19;131(2):324-36
pubmed: 17956733
Molecules. 2019 Oct 31;24(21):
pubmed: 31683674
Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11201-6
pubmed: 14500910
Nat Prod Rep. 2008 Dec;25(6):1131-66
pubmed: 19030606
Front Bioeng Biotechnol. 2019 Jan 29;7:9
pubmed: 30761298
Biotechnol Bioeng. 2011 Jan;108(1):163-74
pubmed: 20824673
Exp Cell Res. 2001 Aug 15;268(2):189-200
pubmed: 11478845
J Org Chem. 1997 Apr 18;62(8):2636-2639
pubmed: 11671610
Exp Cell Res. 1998 Jan 10;238(1):265-72
pubmed: 9457080
Mar Drugs. 2018 Oct 10;16(10):
pubmed: 30308948
Biomol Eng. 2003 Jul;20(4-6):325-31
pubmed: 12919816
J Cell Biochem. 2006 Jun 1;98(3):538-54
pubmed: 16317727
Expert Opin Biol Ther. 2001 Sep;1(5):817-29
pubmed: 11728217
Nat Prod Rep. 2014 Aug;31(8):999-1025
pubmed: 24871201
Environ Microbiol. 2021 May 3;:
pubmed: 33939869
J Bone Joint Surg Am. 2002 Dec;84(12):2123-34
pubmed: 12473698
Mar Drugs. 2020 Apr 05;18(4):
pubmed: 32260516
Mar Drugs. 2019 Nov 09;17(11):
pubmed: 31717541
Eur J Pharm Biopharm. 2017 May;114:69-78
pubmed: 28087378
Tissue Eng Part B Rev. 2014 Dec;20(6):596-608
pubmed: 24749845
Nat Biotechnol. 2016 Aug 9;34(8):828-837
pubmed: 27504778
J Cell Biochem. 1997 Feb;64(2):295-312
pubmed: 9027589
Rheumatology (Oxford). 2001 Jan;40(1):74-83
pubmed: 11157145
Sci Total Environ. 2018 Sep 1;634:1077-1091
pubmed: 29660864
Curr Pharm Des. 2009;15(12):1334-48
pubmed: 19355972
Mar Biotechnol (NY). 2009 Mar-Apr;11(2):260-9
pubmed: 18795368
Chembiochem. 2002 Jul 2;3(7):619-27
pubmed: 12324995
Biotechnol Adv. 2011 Nov-Dec;29(6):610-7
pubmed: 21527337
Arthritis Rheum. 2007 Dec;56(12):4065-73
pubmed: 18050218