The Potential Role of Extracorporeal Cytokine Removal in Hemodynamic Stabilization in Hyperinflammatory Shock.

cytosorb therapy decatecholaminization hemoadsorption hemodynamic stabilization hypeinflammation shock

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
01 Jul 2021
Historique:
received: 10 04 2021
revised: 26 06 2021
accepted: 27 06 2021
entrez: 6 8 2021
pubmed: 7 8 2021
medline: 7 8 2021
Statut: epublish

Résumé

Hemodynamic instability due to dysregulated host response is a life-threatening condition requiring vasopressors and vital organ support. Hemoadsorption with Cytosorb has proven to be effective in reducing cytokines and possibly in attenuating the devastating effects of the cytokine storm originating from the immune over-response to the initial insult. We reviewed the PubMed database to assess evidence of the impact of Cytosorb on norepinephrine needs in the critically ill. We further analyzed those studies including data on control cohorts in a comparative pooled analysis, defining a treatment effect as the standardized mean differences in relative reductions in vasopressor dosage at 24 h. The literature search returned 33 eligible studies. We found evidence of a significant reduction in norepinephrine requirement after treatment: median before, 0.55 (IQR: 0.39-0.90); after, 0.09 (0.00-0.25) μg/kg/min,

Identifiants

pubmed: 34356830
pii: biomedicines9070768
doi: 10.3390/biomedicines9070768
pmc: PMC8301410
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Fatime Hawchar (F)

Department of Anaesthesiology and Intensive Therapy, University of Szeged, 6 Semmelweis Str., H-6725 Szeged, Hungary.

Cristina Rao (C)

Cytosorbents Europe GmbH, Müggelseedamm 131, 12587 Berlin, Germany.

Ali Akil (A)

Department of Thoracic Surgery and Lung Support, Klinikum Ibbenbueren, Grosse Strasse 41, 49477 Ibbenbueren, Germany.

Yatin Mehta (Y)

Institute of Critical Care and Anesthesiology, Medanta the Medicity, CH Baktawar Singh Rd, Gurugram 122001, Haryana, India.

Christopher Rugg (C)

Department of Anesthesiology and Critical Care Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.

Joerg Scheier (J)

Cytosorbents Europe GmbH, Müggelseedamm 131, 12587 Berlin, Germany.

Harriet Adamson (H)

Cytosorbents Europe GmbH, Müggelseedamm 131, 12587 Berlin, Germany.

Efthymios Deliargyris (E)

Cytosorbents Corporation, 7 Deer Park Drive Suite K, Monmouth Junction, NJ 08852, USA.

Zsolt Molnar (Z)

Department of Anaesthesiology and Intensive Therapy, University of Szeged, 6 Semmelweis Str., H-6725 Szeged, Hungary.
Institute for Translational Medicine, School of Medicine, University of Pécs, Szigeti Str. 12, H-7624 Pécs, Hungary.
Department of Anaesthesiology and Intensive Therapy and Pain Management, Poznan University for Medical Sciences, 61-701 Poznan, Poland.
Department of Anaesthesiology and Intensive Therapy, Semmelweis University, 1085 Budapest, Hungary.

Classifications MeSH