T2-High Endotype and Response to Biological Treatments in Patients with
Bronchiectasis
T2-high
eosinophilia
type 2 inflammation
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
02 Jul 2021
02 Jul 2021
Historique:
received:
20
05
2021
revised:
28
06
2021
accepted:
29
06
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
7
8
2021
Statut:
epublish
Résumé
Although bronchiectasis pathophysiology has been historically understood around the presence of airway neutrophilic inflammation, recent experiences are consistent with the identification of a type 2 inflammation (T2) high endotype in bronchiectasis. In order to evaluate prevalence and clinical characteristics of bronchiectasis patients with a T2-high endotype and explore their response to biologicals, two studies were carried out. In a cross-sectional study, bronchiectasis adults without asthma underwent clinical, radiological, and microbiological assessment, along with blood eosinophils and oral fractional exhaled nitric oxide (FeNO) evaluation, during stable state. Prevalence and characteristics of patients with a T2- high endotype (defined by the presence of either eosinophils blood count ≥300 cells·µL
Identifiants
pubmed: 34356836
pii: biomedicines9070772
doi: 10.3390/biomedicines9070772
pmc: PMC8301446
pii:
doi:
Types de publication
Journal Article
Langues
eng
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