Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line.

NF-κB Sirtuin-1 Sirtuin-1 activating compound aging inflammation monoterpene

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
04 Jul 2021
Historique:
received: 07 05 2021
revised: 22 06 2021
accepted: 01 07 2021
entrez: 6 8 2021
pubmed: 7 8 2021
medline: 7 8 2021
Statut: epublish

Résumé

The signaling pathways involved in age-related inflammation are increasingly recognized as targets for the development of preventive and therapeutic strategies. Our previous study elucidated the structure-activity relationship of monoterpene compounds derived from

Identifiants

pubmed: 34356841
pii: biomedicines9070777
doi: 10.3390/biomedicines9070777
pmc: PMC8301357
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Fundação para a Ciência e a Tecnologia
ID : POCI-01-0145-FEDER-028424
Organisme : Fundação para a Ciência e a Tecnologia
ID : UID/NEU/04539/2019
Organisme : Fundação para a Ciência e a Tecnologia
ID : SFRH/79600/2011

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Auteurs

Cátia Sousa (C)

Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.
Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal.

Bruno Miguel Neves (BM)

Department of Medical Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal.

Alcino Jorge Leitão (AJ)

Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.
Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal.

Alexandrina Ferreira Mendes (AF)

Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.
Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal.

Classifications MeSH