Effective Detection and Monitoring of Glioma Using [

[18F]FPIA PET imaging fatty acid metabolism glioma proliferation

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
13 Jul 2021
Historique:
received: 10 05 2021
revised: 25 06 2021
accepted: 09 07 2021
entrez: 6 8 2021
pubmed: 7 8 2021
medline: 7 8 2021
Statut: epublish

Résumé

Reprogrammed cellular metabolism is a cancer hallmark. In addition to increased glycolysis, the oxidation of acetate in the citric acid cycle is another common metabolic phenotype. We have recently developed a novel fluorine-18-labelled trimethylacetate-based radiotracer, [ We evaluated the potential of [ Longitudinal PET imaging showed gradual increase in [ Our findings support the use of [

Sections du résumé

BACKGROUND BACKGROUND
Reprogrammed cellular metabolism is a cancer hallmark. In addition to increased glycolysis, the oxidation of acetate in the citric acid cycle is another common metabolic phenotype. We have recently developed a novel fluorine-18-labelled trimethylacetate-based radiotracer, [
METHODS METHODS
We evaluated the potential of [
RESULTS RESULTS
Longitudinal PET imaging showed gradual increase in [
CONCLUSIONS CONCLUSIONS
Our findings support the use of [

Identifiants

pubmed: 34356874
pii: biomedicines9070811
doi: 10.3390/biomedicines9070811
pmc: PMC8301305
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Medical Research Council
ID : MR/T029226/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C2536/A16584
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N020782/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701159
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 25887
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 16584
Pays : United Kingdom

Références

Biochim Biophys Acta. 2011 Jun;1807(6):726-34
pubmed: 21692241
Oncotarget. 2017 Feb 28;8(9):14860-14875
pubmed: 28118603
Nucl Med Rev Cent East Eur. 2002;5(2):127-30
pubmed: 14600871
J Nucl Med. 2008 Feb;49(2):327-34
pubmed: 18199615
Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1669-F1679
pubmed: 31682169
Biochem Pharmacol. 1987 Oct 15;36(20):3405-9
pubmed: 3675603
Cell. 2014 Dec 18;159(7):1603-14
pubmed: 25525878
Br J Cancer. 2010 May 25;102(11):1555-77
pubmed: 20502460
Chem Biol Interact. 2009 Aug 14;180(3):472-7
pubmed: 19539806
Endocrinology. 2020 Feb 1;161(2):
pubmed: 31900483
Neuro Oncol. 2017 Jan;19(1):43-54
pubmed: 27365097
Nat Rev Cancer. 2016 Nov;16(11):718-731
pubmed: 27562463
J Nucl Med. 2014 Sep;55(9):1506-12
pubmed: 25012458
J Nucl Med. 2006 May;47(5):776-82
pubmed: 16644747
Neuro Oncol. 2016 Oct 1;18(suppl_5):v1-v75
pubmed: 28475809
J Nucl Med. 2015 Aug;56(8):1239-45
pubmed: 26045312
Pharmacol Rev. 2002 Dec;54(4):589-98
pubmed: 12429869
Nat Rev Cancer. 2016 Nov;16(11):708-717
pubmed: 27562461
NMR Biomed. 2012 Nov;25(11):1234-44
pubmed: 22419606
Mol Imaging Biol. 2015 Aug;17(4):529-38
pubmed: 25561013
Br J Cancer. 2008 Dec 16;99(12):2037-43
pubmed: 19034272
Neuro Oncol. 2013 Mar;15(3):341-51
pubmed: 23335162
PLoS Biol. 2018 Mar 29;16(3):e2003782
pubmed: 29596410
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
PLoS One. 2017 May 17;12(5):e0176528
pubmed: 28520730
Eur J Nucl Med Mol Imaging. 2012 Jun;39(6):1021-9
pubmed: 22491781
JAMA. 2013 Nov 6;310(17):1842-50
pubmed: 24193082
AJNR Am J Neuroradiol. 2011 Dec;32(11):1978-85
pubmed: 21393407
Curr Neurol Neurosci Rep. 2016 Feb;16(2):17
pubmed: 26759318
Neuro Oncol. 2012 Nov;14 Suppl 5:v1-49
pubmed: 23095881
Eur J Nucl Med Mol Imaging. 2020 Oct;47(11):2549-2561
pubmed: 32123971
Clin Cancer Res. 2019 May 1;25(9):2874-2886
pubmed: 30670496
Cancer Lett. 2015 Jan 28;356(2 Pt A):211-6
pubmed: 24569091
Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:663-687
pubmed: 29309257
Drug Metab Pharmacokinet. 2008;23(4):293-303
pubmed: 18762717
J Neurochem. 2021 Mar;156(5):642-657
pubmed: 32654140

Auteurs

Vessela Vassileva (V)

Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

Marta Braga (M)

Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

Chris Barnes (C)

Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

Justyna Przystal (J)

Department of Medicine, Division of Brain Sciences, Imperial College London, Hammersmith Campus, Burlington Danes, London W12 0NN, UK.

Ali Ashek (A)

Department of Medicine, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

Louis Allott (L)

Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

Diana Brickute (D)

Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

Joel Abrahams (J)

Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

Keittisak Suwan (K)

Department of Medicine, Division of Brain Sciences, Imperial College London, Hammersmith Campus, Burlington Danes, London W12 0NN, UK.

Angel M Carcaboso (AM)

Institute de Recerca Sant Joan de Deu, 08950 Barcelona, Spain.

Amin Hajitou (A)

Department of Medicine, Division of Brain Sciences, Imperial College London, Hammersmith Campus, Burlington Danes, London W12 0NN, UK.

Eric O Aboagye (EO)

Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

Classifications MeSH