Biphasic Effects of Blue Light Irradiation on Human Umbilical Vein Endothelial Cells.
angiogenesis
apoptosis
blue light
endothelial cell
photobiomodulation
reactive oxygen species
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
16 Jul 2021
16 Jul 2021
Historique:
received:
21
06
2021
revised:
12
07
2021
accepted:
12
07
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
7
8
2021
Statut:
epublish
Résumé
Blue light regulates biological function in various cells, such as proliferation, oxidative stress, and cell death. We employed blue light illumination on human umbilical vein endothelial cells utilizing a LED device at 453 nm wavelength and revealed a novel biphasic response on human umbilical vein endothelial cells (HUVECs). The results showed that low fluence blue light irradiation promoted the fundamental cell activities, including cell viability, migration and angiogenesis by activating the angiogenic pathways such as the VEGF signaling pathway. In contrast, high fluence illumination caused the opposite effect on those activities by upregulating pro-apoptotic signaling cascades like ferroptosis, necroptosis and the p53 signaling pathways. Our results provide an underlying insight into photobiomodulation by blue light and may help to implement potential treatment strategies for treating angiogenesis-dependent diseases.
Identifiants
pubmed: 34356893
pii: biomedicines9070829
doi: 10.3390/biomedicines9070829
pmc: PMC8301484
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : China Sponsorship Council
ID : 201706230250; 201706230257
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