Tissue- and Liquid-Based Biomarkers in Prostate Cancer Precision Medicine.
liquid-based biomarkers
precision medicine
prostate cancer
tissue-based biomarkers
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
15 Jul 2021
15 Jul 2021
Historique:
received:
14
06
2021
revised:
06
07
2021
accepted:
13
07
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
7
8
2021
Statut:
epublish
Résumé
Worldwide, prostate cancer (PC) is the second-most-frequently diagnosed male cancer and the fifth-most-common cause of all cancer-related deaths. Suspicion of PC in a patient is largely based upon clinical signs and the use of prostate-specific antigen (PSA) levels. Although PSA levels have been criticised for a lack of specificity, leading to PC over-diagnosis, it is still the most commonly used biomarker in PC management. Unfortunately, PC is extremely heterogeneous, and it can be difficult to stratify patients whose tumours are unlikely to progress from those that are aggressive and require treatment intensification. Although PC-specific biomarker research has previously focused on disease diagnosis, there is an unmet clinical need for novel prognostic, predictive and treatment response biomarkers that can be used to provide a precision medicine approach to PC management. In particular, the identification of biomarkers at the time of screening/diagnosis that can provide an indication of disease aggressiveness is perhaps the greatest current unmet clinical need in PC management. Largely through advances in genomic and proteomic techniques, exciting pre-clinical and clinical research is continuing to identify potential tissue, blood and urine-based PC-specific biomarkers that may in the future supplement or replace current standard practices. In this review, we describe how PC-specific biomarker research is progressing, including the evolution of PSA-based tests and those novel assays that have gained clinical approval. We also describe alternative diagnostic biomarkers to PSA, in addition to biomarkers that can predict PC aggressiveness and biomarkers that can predict response to certain therapies. We believe that novel biomarker research has the potential to make significant improvements to the clinical management of this disease in the near future.
Identifiants
pubmed: 34357131
pii: jpm11070664
doi: 10.3390/jpm11070664
pmc: PMC8306523
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : The Urology Foundation
ID : R46933
Références
J Urol. 1997 Jan;157(1):195-8
pubmed: 8976249
J Urol. 2013 Mar;189(3):1110-6
pubmed: 22999998
Rev Urol. 2016;18(3):123-132
pubmed: 27833462
Urol Oncol. 2019 Feb;37(2):138-144
pubmed: 30528698
Urology. 2019 Jun;128:62-65
pubmed: 29660369
Prostate Cancer Prostatic Dis. 2020 Dec;23(4):607-614
pubmed: 32382078
J Urol. 2015 Jul;194(1):65-72
pubmed: 25636659
Mol Med Rep. 2016 Jun;13(6):4549-60
pubmed: 27081843
JAMA. 2018 Mar 6;319(9):883-895
pubmed: 29509864
Sci Rep. 2020 Feb 12;10(1):2463
pubmed: 32051423
Cancer Res. 1999 Dec 1;59(23):5975-9
pubmed: 10606244
Prostate Cancer Prostatic Dis. 2018 Apr;21(1):78-84
pubmed: 29158509
Am J Clin Pathol. 2008 Jan;129(1):57-66
pubmed: 18089489
BJU Int. 2012 Feb;109(3):360-6
pubmed: 21883822
BJU Int. 2017 Nov;120(5B):E80-E86
pubmed: 28371163
Nat Med. 2011 Feb;17(2):211-5
pubmed: 21240262
Prostate. 2014 Feb;74(3):250-9
pubmed: 24166488
J Clin Oncol. 2018 Feb 20;36(6):581-590
pubmed: 29185869
J Urol. 2018 Oct;200(4):758-766
pubmed: 29758219
Eur Urol. 2011 Nov;60(5):1045-54
pubmed: 21871709
Prostate. 2011 Apr;71(5):489-97
pubmed: 20878952
Jpn J Clin Oncol. 2009 Nov;39(11):727-31
pubmed: 19674994
Oncol Rev. 2020 Apr 30;14(1):449
pubmed: 32399138
Medicine (Baltimore). 2018 Mar;97(13):e0249
pubmed: 29595681
Neoplasia. 2013 Apr;15(4):399-408
pubmed: 23555185
Int J Radiat Oncol Biol Phys. 2001 Jul 15;50(4):845-9
pubmed: 11429210
Am Health Drug Benefits. 2016 Dec;9(9):497-502
pubmed: 28465777
ACS Appl Mater Interfaces. 2019 Dec 18;11(50):46645-46650
pubmed: 31765118
Eur Urol. 2020 Dec;78(6):822-830
pubmed: 32811715
JAMA Oncol. 2016 Jul 1;2(7):882-9
pubmed: 27032035
Scand J Prim Health Care. 2020 Sep;38(3):315-322
pubmed: 32772613
Urology. 2017 Jul;105:123-128
pubmed: 28431993
JAMA. 1998 May 20;279(19):1542-7
pubmed: 9605898
J Hematol Oncol. 2021 Mar 29;14(1):51
pubmed: 33781305
Pathol Oncol Res. 2020 Apr;26(2):1049-1056
pubmed: 30989489
Per Med. 2019 Nov;16(6):491-499
pubmed: 31483217
Cancer Epidemiol Biomarkers Prev. 2012 Sep;21(9):1497-509
pubmed: 22736790
Prostate Cancer Prostatic Dis. 2019 Mar;22(1):24-38
pubmed: 30131604
Int J Mol Sci. 2017 Apr 17;18(4):
pubmed: 28420168
Br J Cancer. 2015 Jul 28;113(3):382-9
pubmed: 26103570
Int J Radiat Oncol Biol Phys. 2013 Aug 1;86(5):848-53
pubmed: 23755923
J Natl Compr Canc Netw. 2018 Nov;16(11):1340-1351
pubmed: 30442734
Int J Mol Sci. 2013 May 28;14(6):11347-55
pubmed: 23759986
J Exp Clin Cancer Res. 2015 Feb 06;34:15
pubmed: 25651917
World J Oncol. 2019 Apr;10(2):63-89
pubmed: 31068988
Lancet Oncol. 2016 Nov;17(11):1612-1620
pubmed: 27743920
Clin Cancer Res. 2015 Jul 1;21(13):3061-70
pubmed: 25788493
Br J Cancer. 2007 Sep 3;97(5):678-85
pubmed: 17700571
Prostate. 2017 May;77(6):573-583
pubmed: 27990656
J Clin Oncol. 2005 Sep 1;23(25):6157-62
pubmed: 16135482
World J Urol. 2016 Apr;34(4):509-15
pubmed: 26267808
Cancer. 1998 Jan 15;82(2):342-8
pubmed: 9445192
Sci Transl Med. 2011 Aug 3;3(94):94ra72
pubmed: 21813756
BJU Int. 2017 Dec;120(6):793-798
pubmed: 28058757
BMC Cancer. 2017 Apr 17;17(1):273
pubmed: 28412973
Eur Urol. 2010 Jun;57(6):921-7
pubmed: 20189711
Prostate Cancer Prostatic Dis. 2018 Apr;21(1):57-63
pubmed: 29259293
Int J Cancer. 2015 Dec 15;137(12):2795-802
pubmed: 25557753
World J Urol. 2018 Sep;36(9):1495-1500
pubmed: 29679140
Lancet Oncol. 2015 Dec;16(16):1667-76
pubmed: 26563502
Br J Cancer. 2009 May 19;100(10):1603-7
pubmed: 19401683
Oncol Rep. 2013 Nov;30(5):2011-9
pubmed: 23970180
Urol Int. 2020;104(3-4):181-186
pubmed: 32224611
Lancet Oncol. 2011 Mar;12(3):245-55
pubmed: 21310658
Prostate. 2021 May;81(7):368-376
pubmed: 33734461
Lancet. 2014 Dec 6;384(9959):2027-35
pubmed: 25108889
J Urol. 2003 Nov;170(5):1787-91
pubmed: 14532777
J Clin Oncol. 2016 Apr 20;34(12):1402-18
pubmed: 26903579
Cancer Cell. 2010 Jul 13;18(1):11-22
pubmed: 20579941
J Steroid Biochem Mol Biol. 2017 Feb;166:1-15
pubmed: 27117390
J Clin Oncol. 2014 Dec 20;32(36):4066-72
pubmed: 25385735
Clin Cancer Res. 2012 Sep 15;18(18):5134-43
pubmed: 22832933
CA Cancer J Clin. 2018 Jul;68(4):297-316
pubmed: 29846940
Curr Opin Endocrinol Diabetes Obes. 2013 Jun;20(3):204-9
pubmed: 23609043
J Clin Oncol. 2020 May 10;38(14):1549-1557
pubmed: 32130059
Urology. 2020 Sep;143:103-111
pubmed: 32525077
J Urol. 2019 Oct;202(4):702-709
pubmed: 31026214
Eur Urol. 2008 Nov;54(5):1081-8
pubmed: 18602209
JAMA. 2005 Jul 27;294(4):440-7
pubmed: 16046650
BJU Int. 2016 Nov;118(5):723-730
pubmed: 27112799
Genes Dev. 2011 Oct 15;25(20):2158-72
pubmed: 22012619
Oncotarget. 2016 Jun 7;7(23):35478-89
pubmed: 27007155
Cell. 2018 Jun 14;173(7):1770-1782.e14
pubmed: 29906450
Eur Urol. 2019 Jun;75(6):967-987
pubmed: 30342843
BJU Int. 2017 Nov;120(5):659-665
pubmed: 28370948
J Clin Oncol. 2003 Jan 15;21(2):383-91
pubmed: 12525533
Mod Pathol. 2015 Jan;28(1):128-137
pubmed: 24993522
Mod Pathol. 2010 Oct;23(10):1325-33
pubmed: 20562851
Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18490-5
pubmed: 19001271
In Vivo. 2020 Jan-Feb;34(1):393-396
pubmed: 31882504
Eur Urol. 2003 Jul;44(1):8-15; discussion 15-6
pubmed: 12814669
Br J Med Surg Urol. 2012 Jul 1;5(4):162-168
pubmed: 22712027
Prostate Cancer Prostatic Dis. 2019 Mar;22(1):137-142
pubmed: 30171228
Eur Urol. 2015 Mar;67(3):470-9
pubmed: 25306226
J Clin Oncol. 2004 Jun 1;22(11):2133-40
pubmed: 15169799
Eur Urol. 2015 Jul;68(1):123-31
pubmed: 25465337
J Clin Oncol. 2006 Aug 10;24(23):3726-34
pubmed: 16720680
Eur Urol. 2021 Mar;79(3):374-383
pubmed: 33293078
J Clin Oncol. 2019 May 1;37(13):1120-1129
pubmed: 30865549
BMC Med. 2008 Jul 08;6:19
pubmed: 18611265
N Engl J Med. 2004 May 27;350(22):2239-46
pubmed: 15163773
J Urol. 2014 Oct;192(4):1081-7
pubmed: 24747657
J Urol. 1992 Mar;147(3 Pt 2):815-6
pubmed: 1371554
World J Mens Health. 2019 Sep;37(3):288-295
pubmed: 30209899
Urology. 2020 Aug;142:166-173
pubmed: 32277993
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
J Pathol. 1996 Nov;180(3):295-9
pubmed: 8958808
BMC Urol. 2020 Sep 1;20(1):138
pubmed: 32873277
Mod Pathol. 2012 Nov;25(11):1543-9
pubmed: 22684219
Nanoscale. 2019 Sep 7;11(33):15530-15536
pubmed: 31393497
J Urol. 2019 Aug;202(2):256-263
pubmed: 31026217
Sci Rep. 2020 Jun 4;10(1):9104
pubmed: 32499554
Clin Chim Acta. 2014 Aug 5;435:53-8
pubmed: 24803095
Cancer Cell. 2020 Oct 12;38(4):489-499.e3
pubmed: 32916128
Adv Cancer Res. 2015;126:345-82
pubmed: 25727153
Urology. 2019 Apr;126:89-95
pubmed: 30580007
N Engl J Med. 2008 Mar 20;358(12):1250-61
pubmed: 18354103
Int J Radiat Oncol Biol Phys. 2007 Apr 1;67(5):1425-9
pubmed: 17394943
World J Urol. 2021 Jun;39(6):1869-1877
pubmed: 32681273
Onco Targets Ther. 2017 Oct 24;10:5089-5097
pubmed: 29123407
Clin Chem Lab Med. 2013 Apr;51(4):729-39
pubmed: 23154423
Can Urol Assoc J. 2012 Apr;6(2):121-7
pubmed: 22511420
Urol Oncol. 2004 Jul-Aug;22(4):307-12
pubmed: 15283888
Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):965-74
pubmed: 16798415
Prostate Cancer Prostatic Dis. 2020 Mar;23(1):24-37
pubmed: 31197228
J Urol. 2011 May;185(5):1650-5
pubmed: 21419439
BMC Cancer. 2020 Apr 22;20(1):340
pubmed: 32321456
Transl Androl Urol. 2018 Sep;7(Suppl 4):S384-S391
pubmed: 30363476
Urol Oncol. 2017 Aug;35(8):499-506
pubmed: 28648414
Clin Genitourin Cancer. 2019 Dec;17(6):470-475.e1
pubmed: 31530439
Eur Urol. 2015 Sep;68(3):464-70
pubmed: 25454615
BMC Urol. 2021 Feb 25;21(1):29
pubmed: 33632199
Radiat Oncol. 2013 Jul 08;8:170
pubmed: 23835115
Nat Genet. 2014 Oct;46(10):1103-9
pubmed: 25217961
J Clin Oncol. 2017 Jun 20;35(18):1991-1998
pubmed: 28358655
Nat Rev Genet. 2011 Nov 18;12(12):861-74
pubmed: 22094949
Biomed Res Int. 2014;2014:526341
pubmed: 24809052
Can Urol Assoc J. 2020 May;14(5):E214-E219
pubmed: 31793864
Int J Radiat Oncol Biol Phys. 2013 Jun 1;86(2):317-23
pubmed: 23474109
Int J Mol Sci. 2020 Feb 11;21(4):
pubmed: 32053990
AJR Am J Roentgenol. 2020 Mar;214(3):574-578
pubmed: 31913068
J Natl Cancer Inst. 2009 Mar 18;101(6):374-83
pubmed: 19276453
N Engl J Med. 2013 Jan 31;368(5):436-45
pubmed: 23363497
Eur Urol. 2004 Aug;46(2):182-6; discussion 187
pubmed: 15245811
J Reprod Fertil. 1970 Aug;22(3):573-4
pubmed: 4989232
Ont Health Technol Assess Ser. 2017 May 1;17(6):1-75
pubmed: 28572867
JAMA Oncol. 2016 Nov 1;2(11):1441-1449
pubmed: 27262168
Cancer. 1997 Jan 1;79(1):104-9
pubmed: 8988733
Clin Chem. 2013 Jan;59(1):306-14
pubmed: 23213080
Eur Urol. 2019 Mar;75(3):515-522
pubmed: 30391079
J Clin Oncol. 2013 Apr 10;31(11):1428-34
pubmed: 23460710
Urol Int. 2018;100(3):251-262
pubmed: 29161715
Clin Cancer Res. 2008 Jun 1;14(11):3380-5
pubmed: 18519767
BJU Int. 2016 Apr;117 Suppl 4:68-75
pubmed: 26890320
Eur Urol. 2018 Jan;73(1):129-138
pubmed: 28988753
Cancer Res. 2002 May 1;62(9):2695-8
pubmed: 11980670
J Clin Oncol. 2018 Feb 1;36(4):376-382
pubmed: 29261442
JAMA. 2005 Jul 6;294(1):66-70
pubmed: 15998892
Eur Urol. 2016 Mar;69(3):505-11
pubmed: 25979570
Prostate. 2016 Sep;76(12):1078-87
pubmed: 27121847
Eur Urol. 2019 Apr;75(4):558-561
pubmed: 30396635
PLoS One. 2015 Apr 14;10(4):e0124245
pubmed: 25874774
BMC Urol. 2020 Sep 7;20(1):144
pubmed: 32894109
PLoS One. 2018 Aug 9;13(8):e0201384
pubmed: 30092002
CA Cancer J Clin. 2021 Jan;71(1):7-33
pubmed: 33433946
J Urol. 2008 Jan;179(1):156-61; discussion 161-2
pubmed: 18001801
BJU Int. 2015 Oct;116(4):556-67
pubmed: 25762434
Int J Cancer. 2017 Sep 15;141(6):1231-1239
pubmed: 28571116
Asian J Urol. 2017 Jul;4(3):148-151
pubmed: 29264223
J Proteome Res. 2009 Feb;8(2):613-9
pubmed: 19035787
Urol Oncol. 2015 Apr;33(4):163.e15-23
pubmed: 25575715
Mod Pathol. 2016 Aug;29(8):904-14
pubmed: 27174589
Mol Clin Oncol. 2018 Dec;9(6):656-660
pubmed: 30546897
Mol Cancer Ther. 2015 Apr;14(4):847-56
pubmed: 25695955
BJU Int. 2012 Oct;110(7):1032-9
pubmed: 22260273
JCI Insight. 2018 Nov 2;3(21):
pubmed: 30385730
Eur Urol. 2016 Jul;70(1):45-53
pubmed: 25985884
Mod Pathol. 2009 Aug;22(8):1083-93
pubmed: 19407851
Oncogene. 2007 Jul 5;26(31):4596-9
pubmed: 17237811
BJU Int. 2018 Apr;121(4):619-626
pubmed: 29232037
Glycobiology. 2003 Jun;13(6):457-70
pubmed: 12626390
Lancet Oncol. 2016 Jun;17(6):727-737
pubmed: 27155740
Biomark Res. 2021 Feb 18;9(1):14
pubmed: 33602330
Transl Oncol. 2018 Jun;11(3):628-632
pubmed: 29574327
Eur Urol. 2014 Feb;65(2):467-79
pubmed: 24321502
J Clin Oncol. 2015 Mar 10;33(8):944-51
pubmed: 25667284
J Mol Med (Berl). 2013 Apr;91(4):431-7
pubmed: 23519402
N Engl J Med. 1987 Oct 8;317(15):909-16
pubmed: 2442609
Arch Ital Urol Androl. 2009 Dec;81(4):195-8
pubmed: 20608139
Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4118-24
pubmed: 15217948
J Urol. 2019 Jul;202(1):90-95
pubmed: 30810466
Prostate Cancer Prostatic Dis. 2020 Dec;23(4):615-621
pubmed: 32606435
JCO Precis Oncol. 2020;4:370-381
pubmed: 32462107
Urology. 2019 Apr;126:76-82
pubmed: 30611659
Eur Urol. 2017 Nov;72(5):845-852
pubmed: 28528811
Clin Chem Lab Med. 2020 Feb 25;58(3):326-339
pubmed: 31714881
Eur Urol. 2018 Aug;74(2):204-210
pubmed: 29331214
Sci Rep. 2020 Mar 6;10(1):4240
pubmed: 32144327
J Urol. 2014 Jun;191(6):1743-8
pubmed: 24333241
Can Urol Assoc J. 2012 Feb;6(1):46-50
pubmed: 22396369
Onco Targets Ther. 2017 Jun 12;10:2943-2949
pubmed: 28652776
World J Urol. 2015 Aug;33(8):1165-71
pubmed: 25344896
J Urol. 2018 Dec;200(6):1215-1220
pubmed: 29906434
BJU Int. 2016 Jan;117(1):72-9
pubmed: 25818705
J Urol. 2018 Mar;199(3):683-690
pubmed: 29203269
Proc Natl Acad Sci U S A. 2011 May 24;108(21):8809-14
pubmed: 21555566
Cancer Epidemiol Biomarkers Prev. 2020 Jan;29(1):246-253
pubmed: 31757784
Eur Urol. 2018 Apr;73(4):521-523
pubmed: 29306513
Prostate Cancer. 2013;2013:717080
pubmed: 24222860
Clin Cancer Res. 2011 Oct 15;17(20):6563-73
pubmed: 21878536
Eur Urol. 2013 Dec;64(6):876-92
pubmed: 23787356
Prostate Cancer Prostatic Dis. 2017 Sep;20(3):339-342
pubmed: 28417979
Prostate Cancer Prostatic Dis. 2010 Jun;13(2):126-31
pubmed: 20084081
Indian J Urol. 2019 Jan-Mar;35(1):6-17
pubmed: 30692719
Chin J Cancer Res. 2016 Feb;28(1):58-64
pubmed: 27041927
Urology. 2014 Aug;84(2):365-71
pubmed: 24925834
Eur J Cancer. 2015 May;51(7):817-24
pubmed: 25794605
Eur Urol. 2018 Dec;74(6):731-738
pubmed: 30237023
Eur Urol. 2015 Apr;67(4):795-802
pubmed: 25454616
Clin Biochem. 2010 Jul;43(10-11):926-8
pubmed: 20450900
JAMA. 2017 Jun 27;317(24):2532-2542
pubmed: 28655021
J Urol. 1996 Aug;156(2 Pt 1):350-4
pubmed: 8683677
Cancer Cell Int. 2007 Mar 15;7:2
pubmed: 17362521
J Clin Oncol. 2010 May 20;28(15):2493-8
pubmed: 20421547
Front Oncol. 2019 Nov 22;9:1287
pubmed: 31824860
Theranostics. 2016 May 24;6(8):1190-204
pubmed: 27279911
Cancer. 2008 Jan 1;112(1):55-60
pubmed: 17968996
J Clin Oncol. 2006 Aug 20;24(24):3984-90
pubmed: 16921051
Eur Urol. 2012 Nov;62(5):745-52
pubmed: 22704366
Eur Urol Oncol. 2019 Sep;2(5):589-596
pubmed: 31411980
BJU Int. 2017 Dec;120(6):808-814
pubmed: 28481440
Cancer Cell. 2018 May 14;33(5):843-852.e4
pubmed: 29657128
Cancer Cell. 2011 Jun 14;19(6):792-804
pubmed: 21620777
J Urol. 2014 Aug;192(2):409-14
pubmed: 24508632
Eur Urol. 2012 Dec;62(6):953-61
pubmed: 22652152
Clin Cancer Res. 2010 Mar 1;16(5):1572-6
pubmed: 20160063
Curr Med Res Opin. 2014 Aug;30(8):1547-56
pubmed: 24803160
Rev Urol. 2015;17(4):231-40
pubmed: 26839521
Front Oncol. 2020 Nov 24;10:565382
pubmed: 33330035
Turk J Urol. 2014 Jun;40(2):82-8
pubmed: 26328156
JAMA. 1999 May 5;281(17):1591-7
pubmed: 10235151
J Urol. 2013 Aug;190(2):496-501
pubmed: 23466239
J Urol. 2020 Sep;204(3):466-475
pubmed: 32191585
Ann Agric Environ Med. 2019 Mar 22;26(1):120-124
pubmed: 30922041
Eur Urol. 2017 Feb;71(2):183-192
pubmed: 27451135
N Engl J Med. 2014 Sep 11;371(11):1028-38
pubmed: 25184630
Oncotarget. 2017 Apr 27;8(45):79279-79288
pubmed: 29108306
Cancer Manag Res. 2020 Oct 16;12:10251-10260
pubmed: 33116879
J Urol. 2013 Jul;190(1):64-9
pubmed: 23416644
J Urol. 2016 Mar;195(3):612-8
pubmed: 26403586
Prostate Cancer Prostatic Dis. 2019 Mar;22(1):101-109
pubmed: 30127462
Urology. 2006 Nov;68(5):1067-71
pubmed: 17095070
Eur Urol. 2011 Jul;60(1):21-8
pubmed: 21295399
Cancer Biomark. 2016 Jun 7;17(1):83-8
pubmed: 27314296
Sci Rep. 2016 Oct 17;6:35364
pubmed: 27748407
Nat Rev Cancer. 2015 Sep;15(9):540-55
pubmed: 26289314
Urology. 2016 May;91:12-8
pubmed: 26850815
Cancer Manag Res. 2020 Sep 07;12:8105-8114
pubmed: 32982407
Arch Pathol Lab Med. 2021 Apr 1;145(4):461-493
pubmed: 32589068
Mod Pathol. 2007 Apr;20(4):467-73
pubmed: 17334351
Urol Oncol. 2018 Aug;36(8):385-388
pubmed: 29555412
Prostate Cancer Prostatic Dis. 2017 Jun;20(2):228-233
pubmed: 28117387
Eur Urol. 2015 Aug;68(2):207-13
pubmed: 25682340
Int J Mol Sci. 2017 Feb 22;18(2):
pubmed: 28241428
Urology. 2003 Jul;62(1):177-81
pubmed: 12837462
Cancer Res. 2009 Feb 15;69(4):1400-6
pubmed: 19190343
Eur Urol. 2016 Nov;70(5):740-748
pubmed: 27108162
Trends Mol Med. 2014 Jul;20(7):385-93
pubmed: 24703619
Clin Cancer Res. 2007 Sep 1;13(17):5103-8
pubmed: 17785564
JCO Precis Oncol. 2019;2019:
pubmed: 30801051
Eur Urol. 2015 Jul;68(1):139-46
pubmed: 25151013
Clin Cancer Res. 2015 Jun 1;21(11):2591-600
pubmed: 25733599
JAMA. 2019 Feb 19;321(7):704-706
pubmed: 30743264
Lancet Oncol. 2010 Feb;11(2):174-83
pubmed: 20152769
Sci Transl Med. 2014 Mar 26;6(229):229ra42
pubmed: 24670686
Eur Urol. 2017 Sep;72(3):448-454
pubmed: 27889277
Eur Urol Focus. 2018 Sep;4(5):707-710
pubmed: 28753803
Rev Urol. 2017;19(1):1-10
pubmed: 28522924
Eur Urol. 2017 Apr;71(4):618-629
pubmed: 27568654
J Clin Oncol. 2018 May 20;36(15):1521-1539
pubmed: 29608397
JAMA. 2018 May 8;319(18):1901-1913
pubmed: 29801017
Eur Urol Focus. 2019 Jul;5(4):561-567
pubmed: 29137895
Nat Rev Cancer. 2008 Apr;8(4):268-78
pubmed: 18337732
Urology. 2016 Apr;90:148-52
pubmed: 26809071
J Urol. 2015 Apr;193(4):1163-9
pubmed: 25463993
JAMA. 2018 May 8;319(18):1914-1931
pubmed: 29801018
PLoS One. 2013 Jun 24;8(6):e66855
pubmed: 23826159
J Natl Compr Canc Netw. 2019 May 1;17(5):479-505
pubmed: 31085757
Urol Oncol. 2018 Jun;36(6):310.e7-310.e13
pubmed: 29655620
J Urol. 2013 Dec;190(6):2047-53
pubmed: 23770138
Eur Urol. 2014 Sep;66(3):550-60
pubmed: 24836057
N Engl J Med. 2004 Jul 8;351(2):125-35
pubmed: 15247353
Science. 2005 Oct 28;310(5748):644-8
pubmed: 16254181
Eur Urol. 2018 Apr;73(4):519-520
pubmed: 29373214
Eur Urol Focus. 2021 Mar 20;:
pubmed: 33757735
Clin Chem. 2006 Jun;52(6):1089-95
pubmed: 16627561
Clin Chim Acta. 2019 Jan;488:40-49
pubmed: 30389454
Cancer. 2017 Feb 15;123(4):592-599
pubmed: 27911486
JAMA. 1992 Apr 22-29;267(16):2215-20
pubmed: 1372942
Prostate Cancer Prostatic Dis. 2019 Sep;22(3):399-405
pubmed: 30542054
BMJ. 1995 Nov 18;311(7016):1340-3
pubmed: 7496284
Oncol Rep. 2007 May;17(5):1033-6
pubmed: 17390040
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8
pubmed: 18663219
Lancet. 2020 Oct 31;396(10260):1413-1421
pubmed: 33002429
Hum Pathol. 2010 Jun;41(6):781-93
pubmed: 20466122
Clin Cancer Res. 2010 Jun 15;16(12):3232-9
pubmed: 20400522
Eur Urol. 2013 Jun;63(6):986-94
pubmed: 23375961
Br J Cancer. 2014 Sep 9;111(6):1201-12
pubmed: 25032733
PLoS One. 2012;7(3):e33729
pubmed: 22442719
Korean J Urol. 2015 Sep;56(9):624-9
pubmed: 26366274
J Urol. 2005 Dec;174(6):2191-6
pubmed: 16280762
Eur Urol. 2019 Aug;76(2):142-150
pubmed: 31092338
Prostate. 2010 Jan 1;70(1):10-6
pubmed: 19708043
Curr Opin Genet Dev. 2009 Feb;19(1):82-91
pubmed: 19233641
Mol Cancer Ther. 2017 Nov;16(11):2598-2608
pubmed: 28835386
Urol Oncol. 2015 Aug;33(8):337.e7-14
pubmed: 26055430
Eur Urol. 2018 Aug;74(2):146-154
pubmed: 29478736
Urology. 1996 Dec;48(6A Suppl):81-7
pubmed: 8973706
Sci Rep. 2020 Nov 17;10(1):20015
pubmed: 33203873
Rev Urol. 2004 Spring;6(2):58-72
pubmed: 16985579
Urol Oncol. 2013 Jul;31(5):566-71
pubmed: 21600800
Endocr Relat Cancer. 2016 Dec;23(12):T179-T197
pubmed: 27799360
J Cancer. 2020 Sep 17;11(22):6484-6490
pubmed: 33046969
Eur Urol. 2015 Apr;67(4):778-86
pubmed: 25466945
J Clin Med. 2018 Dec 18;7(12):
pubmed: 30567361
Future Oncol. 2020 Dec;16(36):3061-3074
pubmed: 32902306
Epidemiol Rev. 2001;23(1):181-6
pubmed: 11588846
EXCLI J. 2020 Apr 15;19:501-513
pubmed: 32398974
Prostate Cancer Prostatic Dis. 2020 Mar;23(1):102-107
pubmed: 31243337
Int J Clin Pract. 2017 Jun;71(6):
pubmed: 28497893
Clin Sci (Lond). 2017 Feb 1;131(3):197-210
pubmed: 28057891
J Clin Oncol. 2017 Jul 1;35(19):2149-2156
pubmed: 28384066
Anticancer Res. 2011 Dec;31(12):4445-9
pubmed: 22199313
Cancer Epidemiol Biomarkers Prev. 2020 Jul;29(7):1381-1388
pubmed: 32385116
Asian J Androl. 2016 Jul-Aug;18(4):580-5
pubmed: 27174161
Can J Urol. 2019 Jun;26(3):9758-9762
pubmed: 31180305
Eur Urol. 2019 Nov;76(5):676-685
pubmed: 31036442
Virchows Arch. 2014 Mar;464(3):293-300
pubmed: 24487790
Prostate. 2017 Oct;77(14):1401-1407
pubmed: 28853167
J Magn Reson Imaging. 2020 Apr;51(4):1075-1085
pubmed: 31566845
BJU Int. 2015 Mar;115(3):419-29
pubmed: 24784420
Int J Radiat Oncol Biol Phys. 2005 Jul 1;62(3):714-8
pubmed: 15936550
Mol Clin Oncol. 2017 Feb;6(2):249-254
pubmed: 28357104
N Engl J Med. 1991 Apr 25;324(17):1156-61
pubmed: 1707140
Oncotarget. 2013 Apr;4(4):600-9
pubmed: 23592338
Curr Med Res Opin. 2014 Jun;30(6):1025-31
pubmed: 24576172
Br J Cancer. 2010 Aug 24;103(5):708-14
pubmed: 20664589
Prostate Cancer Prostatic Dis. 2014 Mar;17(1):64-9
pubmed: 24145624
Glycobiology. 2017 Jan;27(1):3-49
pubmed: 27558841
BJU Int. 2018 Aug;122(2):173-180
pubmed: 30134062
Clin Chem. 2019 Jan;65(1):e1-e9
pubmed: 30538125