Urinary Metabolites Reveal Hyperinsulinemia and Insulin Resistance in Polycystic Ovarian Syndrome (PCOS).
PCOS
hyperinsulinemia
insulin resistance
urine metabolomics
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
02 Jul 2021
02 Jul 2021
Historique:
received:
16
06
2021
revised:
25
06
2021
accepted:
25
06
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
7
8
2021
Statut:
epublish
Résumé
The identification of insulin resistance and hyperinsulinemia in polycystic ovary syndrome (PCOS) is not a minor issue. The homeostasis model assessment of insulin resistance index (HOMA) is the most used index of IR (Insulin Resistance), validated in overweight and obese patients but not in normal-weight PCOS subjects, who can still present with increased insulin secretion by an oral glucose tolerance test (OGTT). The evaluation of insulin secretion and resistance represents a still unresolved problem. The aim of this study is to identify a possible yet noninvasive method to properly evaluate the insulin metabolism in young non-diabetic subjects. Girls aged 14-22 years, afferent to the center of Gynecological Diseases in Childhood and Adolescence of Cagliari (Italy), were screened for PCOS. A total of 42 subjects comprised the study group. Hormonal assays, OGTT, transabdominal (TA) or transvaginal (TV) US, and urine collection for
Identifiants
pubmed: 34357331
pii: metabo11070437
doi: 10.3390/metabo11070437
pmc: PMC8307496
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Proteome Res. 2012 May 4;11(5):2937-46
pubmed: 22428626
Acta Eur Fertil. 1976 Dec;7(4):299-314
pubmed: 140576
J Clin Endocrinol Metab. 2020 May 1;105(5):
pubmed: 32119099
Horm Res. 2001;55(2):65-70
pubmed: 11509861
Hum Reprod. 1997 Sep;12(9):1897-901
pubmed: 9363702
Am J Obstet Gynecol. 2002 Nov;187(5):1362-9
pubmed: 12439532
Diabetes. 1979 Dec;28(12):1039-57
pubmed: 510803
Metabolomics. 2020 Jan 24;16(2):20
pubmed: 31980950
Front Microbiol. 2017 Feb 28;8:324
pubmed: 28293234
Fertil Steril. 2018 Aug;110(3):364-379
pubmed: 30033227
PLoS One. 2016 Apr 19;11(4):e0153196
pubmed: 27093642
Lancet. 2007 Aug 25;370(9588):685-97
pubmed: 17720020
J Adolesc Health. 2010 May;46(5):474-81
pubmed: 20413084
Sci Rep. 2018 Sep 14;8(1):13853
pubmed: 30217994
Reprod Biol Endocrinol. 2016 Jul 16;14(1):38
pubmed: 27423183
Nature. 2008 Oct 23;455(7216):1054-6
pubmed: 18948945
Gastroenterology. 2012 Oct;143(4):913-6.e7
pubmed: 22728514
Gynecol Endocrinol. 2011 Jul;27(7):468-74
pubmed: 20540677
J Clin Endocrinol Metab. 1961 Nov;21:1440-7
pubmed: 13892577
J Pediatr Adolesc Gynecol. 2021 Feb 8;:
pubmed: 33571658
Curr Opin Clin Nutr Metab Care. 2011 Sep;14(5):483-90
pubmed: 21681087
Clin Endocrinol (Oxf). 2019 Jan;90(1):138-144
pubmed: 30229990
Clin Endocrinol (Oxf). 2020 Aug;93(2):163-172
pubmed: 32286715
Nutrients. 2019 Sep 23;11(10):
pubmed: 31547562
Fertil Steril. 2004 Sep;82(3):661-5
pubmed: 15374711
Hum Reprod. 1990 Feb;5(2):143-9
pubmed: 2108986
J Endocr Soc. 2019 Jun 14;3(8):1545-1573
pubmed: 31384717
J Pharm Biomed Anal. 2020 Jun 5;185:113262
pubmed: 32222648
Am J Obstet Gynecol. 2010 Sep;203(3):201.e1-5
pubmed: 20435290
J Obstet Gynaecol Res. 2014 May;40(5):1353-60
pubmed: 24606639
Fertil Steril. 2006 Aug;86(2):398-404
pubmed: 16769061
Clin Endocrinol (Oxf). 2017 Dec;87(6):775-782
pubmed: 29044581
BMC Med. 2012 Nov 30;10:153
pubmed: 23198915
Behav Brain Res. 2001 Nov 1;125(1-2):279-84
pubmed: 11682119
Hum Reprod. 1997 Nov;12(11):2508-10
pubmed: 9436695
PLoS One. 2010 May 28;5(5):e10883
pubmed: 20526369
Gynecol Endocrinol. 2015 Apr;31(4):291-5
pubmed: 25561024
Diabetes. 1989 Sep;38(9):1165-74
pubmed: 2670645
Clin Med (Lond). 2015 Dec;15 Suppl 6:s72-6
pubmed: 26634686
Anal Chem. 2006 Jul 1;78(13):4430-42
pubmed: 16808451
Endocrine. 2006 Aug;30(1):19-26
pubmed: 17185788
Nat Rev Endocrinol. 2011 Apr;7(4):219-31
pubmed: 21263450
J Clin Endocrinol Metab. 2004 Mar;89(3):1096-101
pubmed: 15001593
Int J Biochem Cell Biol. 2017 Dec;93:119-128
pubmed: 28782601
Curr Pediatr Rev. 2020;16(3):183-193
pubmed: 31642785
Hum Reprod. 2013 Aug;28(8):2245-52
pubmed: 23595974
Eur J Pediatr. 2019 Dec;178(12):1813-1822
pubmed: 31522316
Med Hypotheses. 2012 Apr;78(4):475-8
pubmed: 22336088
Oncotarget. 2017 Jul 6;8(46):80472-80480
pubmed: 29113318
Hum Reprod Update. 2012 Nov-Dec;18(6):618-37
pubmed: 22767467
J Chromatogr A. 2016 Jan 22;1430:80-95
pubmed: 26763302
Med Hypotheses. 2012 Jul;79(1):104-12
pubmed: 22543078
Obstet Gynecol Surv. 2008 Dec;63(12):796-802
pubmed: 19017415
Reprod Sci. 2021 Mar;28(3):728-735
pubmed: 33174185
Hum Reprod Update. 2015 Jan-Feb;21(1):136-52
pubmed: 25180023
Metabolism. 2017 Jun;71:52-63
pubmed: 28521878
Hum Reprod. 2016 Dec;31(12):2841-2855
pubmed: 27664216
J Endocrinol Invest. 2021 Jun;44(6):1309-1319
pubmed: 33025552
J Clin Endocrinol Metab. 1980 Jan;50(1):113-6
pubmed: 7350174
Hum Reprod. 2017 Dec 1;32(12):2515-2521
pubmed: 29040529