Prevalence and early-life risk factors for tree nut sensitization and allergy in young adults.
Ana o 3
BAMSE
Cor a 1
Cor a 14
Cor a 9
Jug r 1
birth cohort
molecular allergology
sensitization
tree nut allergy
Journal
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
ISSN: 1365-2222
Titre abrégé: Clin Exp Allergy
Pays: England
ID NLM: 8906443
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
06
06
2021
received:
08
04
2021
accepted:
18
06
2021
pubmed:
7
8
2021
medline:
1
4
2022
entrez:
6
8
2021
Statut:
ppublish
Résumé
Tree nut allergy may cause anaphylaxis. There are limited population-based studies on prevalence and early-life risk factors. We evaluated the prevalence of reported symptoms and allergic sensitization to tree nuts at age 24 years in the BAMSE population-based cohort study and assessed early-life factors associated with the development of tree nut allergy. We estimated tree nut allergy prevalence, by analysing questionnaire data on tree nut ingestion and symptoms at age 12, 16 and 24 years, and IgE sensitization at age 24 years to hazelnut, walnut, pecan, cashew, pistachio, Brazil nut, almond extracts and allergen molecules Cor a 1, 9, 14 (hazelnut), Jug r 1 (walnut) and Ana o 3 (cashew). We evaluated eczema, asthma, food allergies, inherited risk of allergy and gender as potential early-life risk factors. Data were available for 2215/4089 (54%) BAMSE study participants, for estimation of the prevalence of tree nut sensitization (21.2%), tree nut allergy symptoms (9.8%) and combined sensitization and symptoms (7.9%, 2.1% for storage protein sensitization and symptoms, 4.3% for any sensitization and non-mild symptoms). Sixty-three per cent of sensitized individuals (295/470) were asymptomatic, but only 76/470 (16%) storage protein sensitized individuals. Egg allergy (OR In this Swedish cohort, we found tree nut whole extract sensitization is common but usually asymptomatic. Storage protein sensitization is a more reliable indicator of tree nut symptoms. Tree nut allergy is associated with early onset, persistent and severe atopic disease.
Sections du résumé
BACKGROUND
Tree nut allergy may cause anaphylaxis. There are limited population-based studies on prevalence and early-life risk factors.
METHODS
We evaluated the prevalence of reported symptoms and allergic sensitization to tree nuts at age 24 years in the BAMSE population-based cohort study and assessed early-life factors associated with the development of tree nut allergy. We estimated tree nut allergy prevalence, by analysing questionnaire data on tree nut ingestion and symptoms at age 12, 16 and 24 years, and IgE sensitization at age 24 years to hazelnut, walnut, pecan, cashew, pistachio, Brazil nut, almond extracts and allergen molecules Cor a 1, 9, 14 (hazelnut), Jug r 1 (walnut) and Ana o 3 (cashew). We evaluated eczema, asthma, food allergies, inherited risk of allergy and gender as potential early-life risk factors.
RESULTS
Data were available for 2215/4089 (54%) BAMSE study participants, for estimation of the prevalence of tree nut sensitization (21.2%), tree nut allergy symptoms (9.8%) and combined sensitization and symptoms (7.9%, 2.1% for storage protein sensitization and symptoms, 4.3% for any sensitization and non-mild symptoms). Sixty-three per cent of sensitized individuals (295/470) were asymptomatic, but only 76/470 (16%) storage protein sensitized individuals. Egg allergy (OR
CONCLUSIONS
In this Swedish cohort, we found tree nut whole extract sensitization is common but usually asymptomatic. Storage protein sensitization is a more reliable indicator of tree nut symptoms. Tree nut allergy is associated with early onset, persistent and severe atopic disease.
Substances chimiques
Allergens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1429-1437Subventions
Organisme : The Swedish Society of Medicine
Organisme : The King Gustaf V 80th Birthday Foundation
Organisme : The Swedish Cancer and Allergy Foundation
Organisme : Swedish Grand lodge of Freemasonry Foundation Barnahuset
Organisme : The Hesselman foundation
Organisme : Karolinska Institutet grants
Organisme : The Samariten Foundation for Paediatric research
Organisme : H2020 European Research Council
ID : 757919
Organisme : The Sven Jerring Foundation
Organisme : Astma- och Allergiförbundet
Organisme : Hjärt-Lungfonden
Organisme : Kerstin Hejdenberg's arresting's scholarship
Organisme : Swedish Research Council
Organisme : Region Stockholm
Organisme : The Konsul Th C Bergh's Foundation
Organisme : The Magnus Bergwall foundation
Organisme : The Pediatric Research Foundation at Astrid Lindgren Children's Hospital
Organisme : Swedish Association for Allergology research grant
Informations de copyright
© 2021 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd.
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