Neuronal perception of the social environment generates an inherited memory that controls the development and generation time of C. elegans.
Weismann barrier
developmental timing
generation time
germline
intergenerational epigentics
pheromones
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
11 10 2021
11 10 2021
Historique:
received:
05
05
2021
revised:
29
06
2021
accepted:
13
07
2021
pubmed:
7
8
2021
medline:
9
4
2022
entrez:
6
8
2021
Statut:
ppublish
Résumé
An old and controversial question in biology is whether information perceived by the nervous system of an animal can "cross the Weismann barrier" to alter the phenotypes and fitness of their progeny. Here, we show that such intergenerational transmission of sensory information occurs in the model organism, C. elegans, with a major effect on fitness. Specifically, that perception of social pheromones by chemosensory neurons controls the post-embryonic timing of the development of one tissue, the germline, relative to others in the progeny of an animal. Neuronal perception of the social environment thus intergenerationally controls the generation time of this animal.
Identifiants
pubmed: 34358445
pii: S0960-9822(21)00986-6
doi: 10.1016/j.cub.2021.07.031
pii:
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4256-4268.e7Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors report no competing interests.