A tail goes viral by forming an anchor and a tether.

Humans Integrases / genetics Leukemia Virus, Murine Transcription Factors / genetics Virus Integration

Journal

Structure (London, England : 1993)
ISSN: 1878-4186
Titre abrégé: Structure
Pays: United States
ID NLM: 101087697

Informations de publication

Date de publication:
05 08 2021
Historique:
entrez: 6 8 2021
pubmed: 7 8 2021
medline: 24 8 2021
Statut: ppublish

Résumé

In this issue of Structure, Aiyer et al. (2021) report NMR structures of BET:MLV IN complexes, highlighting a role for the disordered tail domain of MLV IN in viral integration. These studies expand the understanding of molecular recognition polymorphism in BET complexes and offer insight into cancer and antiviral therapeutics.

Identifiants

DOI: 10.1016/j.str.2021.07.004 PMID: 34358464
pubmed: 34358464
pii: S0969-2126(21)00254-9
doi: 10.1016/j.str.2021.07.004
pii:
doi:

Substances chimiques

Transcription Factors 0
Integrases EC 2.7.7.-

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

783-786

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Elisar Barbar (E)

Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA. Electronic address: elisar.barbar@oregonstate.edu.

Aidan Estelle (A)

Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A tail goes viral by forming an anchor and a tether.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Recombinases › Integrases › A tail goes viral by forming an anchor and a tether.
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Gammaretrovirus › Virus de la leucémie murine › A tail goes viral by forming an anchor and a tether.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › A tail goes viral by forming an anchor and a tether.
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Intégration virale › A tail goes viral by forming an anchor and a tether.