Adverse postnatal developmental effects in offspring from humidifier disinfectant biocide inhaled pregnant rats.
Developmental toxicity
Extended one-generation reproductive toxicity study (EOGRTS)
Hazard identification
Polyhexamethylene guanidine phosphate (PHMG-P)
Reproductive toxicity
Journal
Chemosphere
ISSN: 1879-1298
Titre abrégé: Chemosphere
Pays: England
ID NLM: 0320657
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
22
01
2021
revised:
19
07
2021
accepted:
20
07
2021
pubmed:
7
8
2021
medline:
18
11
2021
entrez:
6
8
2021
Statut:
ppublish
Résumé
Inhalation exposure to polyhexamethylene guanidine phosphate (PHMG-P), one of the primary biocides used in humidifier disinfectants, caused a fatal pulmonary disease in Korea. Pregnant women were also exposed to PHMG-P, and subsequent studies showed that PHMG-P inhalation during pregnancy adversely affects their health and embryo-fetal development. However, the postnatal developmental effects after birth on prenatally PHMG-P-exposed offspring have not yet been investigated. Therefore, in this study, we aimed to examine the postnatal development of prenatally PHMG-P-exposed offspring. Pregnant rats (22 or 24 females per group) were exposed to PHMG-P during pregnancy in a whole-body inhalation chamber at the target concentrations of 0, 0.14, 1.60, and 3.20 mg/m
Identifiants
pubmed: 34358894
pii: S0045-6535(21)02108-1
doi: 10.1016/j.chemosphere.2021.131636
pii:
doi:
Substances chimiques
Disinfectants
0
Guanidines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
131636Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.