Anastasis: Return Journey from Cell Death.

anastasis apoptosis mitochondria stress survival

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
22 Jul 2021
Historique:
received: 29 06 2021
revised: 16 07 2021
accepted: 17 07 2021
entrez: 7 8 2021
pubmed: 8 8 2021
medline: 8 8 2021
Statut: epublish

Résumé

For over 20 years, it has been a dogma that once the integrity of mitochondria is disrupted and proapoptotic proteins that are normally located in the intermembrane space of mitochondria appeared in the cytoplasm, the process of cell death becomes inevitable. However, it has been recently shown that upon removal of the death signal, even at the stage of disturbance in the mitochondria, cells can recover and continue to grow. This phenomenon was named anastasis. Here, we will critically discuss the present knowledge concerning the mechanisms of cell death reversal, or development of anastasis, methods for its detection, and what role signaling from different intracellular compartments plays in anastasis stimulation.

Identifiants

pubmed: 34359573
pii: cancers13153671
doi: 10.3390/cancers13153671
pmc: PMC8345212
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Subventions

Organisme : Russian Science Foundation
ID : 19-15-00125
Organisme : Ministry of Science and Higher Education of the Russian Federation
ID : 075-15-2020-789
Organisme : Russian Foundation of Basic Research
ID : 18-29-09005
Organisme : Cancerfonden
ID : 190345
Organisme : Radiumhemmets Forskningsfonder
ID : 181301

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Auteurs

Victoria Zaitceva (V)

Faculty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia.

Gelina S Kopeina (GS)

Faculty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia.

Boris Zhivotovsky (B)

Faculty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia.
Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177 Stockholm, Sweden.

Classifications MeSH