Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins.
cancer
cancer prevention
keratinocyte carcinoma
mechanism of action
photocarcinogenesis
phytochemicals
skin
skin cancer
ultraviolet radiation
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
22 Jul 2021
22 Jul 2021
Historique:
received:
29
06
2021
revised:
16
07
2021
accepted:
18
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
Ultraviolet radiation (UVR) arising from sun exposure represents a major risk factor in the development of keratinocyte carcinomas (KCs). UVR exposure induces dysregulated signal transduction, oxidative stress, inflammation, immunosuppression and DNA damage, all of which promote the induction and development of photocarcinogenesis. Because the incidence of KCs is increasing, better prevention strategies are necessary. In the concept of photoprevention, protective compounds are administered either topically or systemically to prevent the effects of UVR and the development of skin cancer. In this review, we provide descriptions of the pathways underlying photocarcinogenesis and an overview of selected photoprotective compounds, such as repurposed pharmaceuticals, plant-derived phytochemicals and vitamins. We discuss the protective potential of these compounds and their effects in pre-clinical and human trials, summarising the mechanisms of action involved in preventing photocarcinogenesis.
Identifiants
pubmed: 34359586
pii: cancers13153684
doi: 10.3390/cancers13153684
pmc: PMC8345172
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Danish Research Center for Skin Cancer
ID : N/A
Organisme : The Lundbeck Foundation
ID : R307-2018-3318
Références
Free Radic Biol Med. 2002 Nov 15;33(10):1355-62
pubmed: 12419467
Exp Dermatol. 2008 Aug;17(8):653-8
pubmed: 18312382
Endocrinology. 2006 Oct;147(10):4831-42
pubmed: 16809442
Cancer Lett. 1998 Nov 13;133(1):19-26
pubmed: 9929156
Photochem Photobiol. 2005 Jul-Aug;81(4):830-6
pubmed: 15760277
J Nutr. 2006 May;136(5):1150-5
pubmed: 16614396
J Med Chem. 2004 Oct 7;47(21):5021-40
pubmed: 15456246
Clin Cancer Res. 2003 Aug 15;9(9):3312-9
pubmed: 12960117
J Invest Dermatol. 2007 Mar;127(3):707-15
pubmed: 17170736
Cell Biochem Funct. 2019 Jan;37(1):4-10
pubmed: 30520054
Trends Genet. 1997 Oct;13(10):410-4
pubmed: 9351343
Toxicol Appl Pharmacol. 2014 Oct 1;280(1):127-37
pubmed: 25062774
Sci Rep. 2018 Nov 1;8(1):16199
pubmed: 30385817
Iran J Pharm Res. 2011 Fall;10(4):655-83
pubmed: 24250402
Mutat Res. 2001 Mar;488(1):65-76
pubmed: 11223405
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5826-30
pubmed: 9159159
J Photochem Photobiol B. 2018 Aug;185:241-253
pubmed: 29966991
J Am Acad Dermatol. 1998 Jan;38(1):45-8
pubmed: 9448204
Radiat Environ Biophys. 2007 Mar;46(1):61-8
pubmed: 17279358
Am J Pathol. 2009 Nov;175(5):1952-61
pubmed: 19808641
Cancer Prev Res (Phila). 2010 Nov;3(11):1451-61
pubmed: 20947488
Carcinogenesis. 2006 Jan;27(1):95-102
pubmed: 15987716
Cancer Lett. 1995 Aug 16;95(1-2):213-9
pubmed: 7656233
N Engl J Med. 2015 Oct 22;373(17):1618-26
pubmed: 26488693
J Am Acad Dermatol. 2018 Apr;78(4):694-700
pubmed: 29246826
Ann Intern Med. 2002 Jul 2;137(1):25-33
pubmed: 12093242
J Cosmet Dermatol. 2009 Sep;8(3):169-73
pubmed: 19735513
J Am Acad Dermatol. 2004 Dec;51(6):910-8
pubmed: 15583582
J Invest Dermatol. 1992 Apr;98(4):475-80
pubmed: 1312566
Eur J Drug Metab Pharmacokinet. 2013 Mar;38(1):15-25
pubmed: 23161396
Mol Cell Endocrinol. 2011 Dec 5;347(1-2):80-9
pubmed: 21664236
Exp Dermatol. 2014 May;23(5):345-6
pubmed: 24521225
Cancer Chemother Pharmacol. 2011 Sep;68(3):593-601
pubmed: 21116625
Int J Mol Sci. 2012;13(4):4458-83
pubmed: 22605990
J Nucleic Acids. 2010 Jul 25;2010:
pubmed: 20725615
J Am Acad Dermatol. 2021 Jan 20;:
pubmed: 33484767
Arthritis Care Res (Hoboken). 2010 Nov;62(11):1588-93
pubmed: 20556817
Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10124-8
pubmed: 1946433
J Invest Dermatol. 2009 May;129(5):1258-70
pubmed: 19020550
J Clin Aesthet Dermatol. 2012 Sep;5(9):18-23
pubmed: 23050030
Int J Mol Sci. 2020 Jan 25;21(3):
pubmed: 31991834
J Immunol. 2010 Oct 15;185(8):4633-40
pubmed: 20844203
Photochem Photobiol. 1989 Aug;50(2):267-75
pubmed: 2675139
Genes Dis. 2014 Dec 1;1(2):188-198
pubmed: 25642450
Australas J Dermatol. 1977 Aug;18(2):57-61
pubmed: 588190
Mod Rheumatol. 2008;18(6):609-14
pubmed: 18682889
Biochim Biophys Acta. 2005 May 30;1740(2):170-8
pubmed: 15949684
Photochem Photobiol. 2015 Nov;91(6):1435-43
pubmed: 26256790
Int J Cancer. 2003 Jan 1;103(1):110-5
pubmed: 12455062
Mol Med Rep. 2019 Sep;20(3):2294-2302
pubmed: 31322186
Cancers (Basel). 2020 Jul 01;12(7):
pubmed: 32630288
Exp Dermatol. 2008 Nov;17(11):972-4
pubmed: 18616577
BMC Gastroenterol. 2009 Jun 05;9:41
pubmed: 19500343
Mol Cancer Ther. 2007 Mar;6(3):995-1005
pubmed: 17363493
Oxid Med Cell Longev. 2014;2014:162414
pubmed: 25302089
J Photochem Photobiol B. 2006 Mar 1;82(3):173-9
pubmed: 16388959
Lab Invest. 2007 Jan;87(1):49-55
pubmed: 17075575
J Am Acad Dermatol. 2003 Jun;48(6):866-74
pubmed: 12789176
Nutr Cancer. 1991;15(2):97-106
pubmed: 2038569
Lancet. 1994 Dec 3;344(8936):1570-1
pubmed: 7983967
Int J Vitam Nutr Res. 1991;61(1):3-9
pubmed: 1856042
Cancer Epidemiol Biomarkers Prev. 1997 Nov;6(11):949-56
pubmed: 9367069
Free Radic Biol Med. 1998 Jan 1;24(1):55-65
pubmed: 9436614
J Clin Invest. 2000 Jun;105(12):1751-9
pubmed: 10862790
Sci Rep. 2019 Oct 10;9(1):14528
pubmed: 31601842
Radiat Res. 2005 Mar;163(3):296-306
pubmed: 15733037
Exp Dermatol. 2012 Aug;21(8):638-40
pubmed: 22776002
Cancer Biother Radiopharm. 2014 Aug;29(6):257-64
pubmed: 25003799
J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):567-70
pubmed: 15225840
Biochem Biophys Res Commun. 1994 Jun 30;201(3):1132-9
pubmed: 8024554
J Invest Dermatol. 2003 Nov;121(5):1163-7
pubmed: 14708621
Biomed Rep. 2014 May;2(3):419-423
pubmed: 24748986
J Invest Dermatol. 1996 May;106(5):1086-9
pubmed: 8618044
Photodermatol Photoimmunol Photomed. 1999 Jun-Aug;15(3-4):120-6
pubmed: 10404722
Oncogene. 2013 May 23;32(21):2682-9
pubmed: 22751115
Toxicol Appl Pharmacol. 2004 Mar 15;195(3):370-8
pubmed: 15020200
N Engl J Med. 2016 Feb 25;374(8):789
pubmed: 26933857
Cancer Prev Res (Phila). 2014 Feb;7(2):186-98
pubmed: 24217507
Sci Rep. 2018 Jan 11;8(1):423
pubmed: 29323251
Cancer Prev Res (Phila). 2009 Jul;2(7):665-72
pubmed: 19584078
Annu Rev Plant Physiol Plant Mol Biol. 2001 Jun;52:437-467
pubmed: 11337405
Pharmaceutics. 2020 Nov 27;12(12):
pubmed: 33260886
Toxicol Appl Pharmacol. 2001 Oct 15;176(2):110-7
pubmed: 11601887
Front Physiol. 2014 Jun 03;5:166
pubmed: 24917821
Nutr Cancer. 1997;29(2):157-62
pubmed: 9427980
Semin Cancer Biol. 1997 Apr;8(2):63-73
pubmed: 9299584
Cancer Lett. 1996 Oct 22;107(2):217-22
pubmed: 8947516
Photodermatol Photoimmunol Photomed. 1997 Feb-Apr;13(1-2):50-60
pubmed: 9361129
J Invest Dermatol. 2016 May;136(5):1012-1021
pubmed: 26854493
Biochem Biophys Res Commun. 2006 Oct 27;349(3):1171-5
pubmed: 16970913
Ann Surg. 2001 Jul;234(1):10-20
pubmed: 11420478
J Invest Dermatol. 2013 Jan;133(1):258-67
pubmed: 22951730
J Am Acad Dermatol. 2021 Jan 20;:
pubmed: 33484768
J Invest Dermatol. 2017 Oct;137(10):2078-2086
pubmed: 28576736
J Photochem Photobiol B. 2013 Jan 5;118:16-21
pubmed: 23178081
Biology (Basel). 2020 Nov 27;9(12):
pubmed: 33261116
Nat Rev Mol Cell Biol. 2014 Dec;15(12):786-801
pubmed: 25415508
Mol Carcinog. 2002 Jul;34(3):121-30
pubmed: 12112306
Chemother Res Pract. 2012;2012:282570
pubmed: 23320169
Proc Natl Acad Sci U S A. 1984 Apr;81(7):2085-7
pubmed: 6425826
Chem Rev. 2011 Oct 12;111(10):5944-72
pubmed: 21861450
Photochem Photobiol. 2016 Nov;92(6):816-825
pubmed: 27859308
Carcinogenesis. 1998 Apr;19(4):663-6
pubmed: 9600352
Photochem Photobiol. 2010 Nov-Dec;86(6):1318-26
pubmed: 20946358
Bioessays. 1995 Jul;17(7):651-60
pubmed: 7646487
Clin Cancer Res. 2000 Oct;6(10):3864-9
pubmed: 11051231
Am J Pathol. 2010 Aug;177(2):555-62
pubmed: 20616346
Mol Cell Biol. 2014 Jan;34(2):148-57
pubmed: 24190973
J Nutr. 2006 Jun;136(6):1565-9
pubmed: 16702322
Br J Dermatol. 2017 May;176(5):1402-1404
pubmed: 28118480
Carcinogenesis. 2005 Mar;26(3):657-64
pubmed: 15618233
Curr Biol. 2005 Jan 26;15(2):105-15
pubmed: 15668165
Immunol Today. 1992 Jul;13(7):250-4
pubmed: 1388651
J Clin Invest. 2012 Sep;122(9):3316-29
pubmed: 22922257
Free Radic Biol Med. 1998 Dec;25(9):1006-12
pubmed: 9870553
Arch Dermatol Res. 1979 Aug;266(1):91-4
pubmed: 507933
Mol Aspects Med. 2003 Aug-Oct;24(4-5):149-59
pubmed: 12892992
Chin Med J (Engl). 2006 Feb 20;119(4):282-7
pubmed: 16537022
Exp Dermatol. 2014 Jul;23(7):526-8
pubmed: 24862559
Cancer Chemother Pharmacol. 2005 Jul;56(1):63-9
pubmed: 15791456
Sci Rep. 2017 Jun 27;7(1):4310
pubmed: 28655934
Acta Derm Venereol. 2002;82(1):21-4
pubmed: 12013192
J Agric Food Chem. 2000 Oct;48(10):4581-9
pubmed: 11052704
Cell Mol Neurobiol. 2017 Jan;37(1):155-168
pubmed: 26961544
J Clin Aesthet Dermatol. 2015 Feb;8(2):19-23
pubmed: 25741399
Photodermatol Photoimmunol Photomed. 2008 Jun;24(3):134-41
pubmed: 18477132
J Invest Dermatol. 1981 Mar;76(3):178-80
pubmed: 7240786
Photochem Photobiol. 2020 Jul;96(4):870-876
pubmed: 32077107
Photochem Photobiol Sci. 2012 Dec;11(12):1825-30
pubmed: 22907250
Antioxidants (Basel). 2021 Jan 27;10(2):
pubmed: 33514043
J Photochem Photobiol B. 2019 Jul;196:111511
pubmed: 31129510
J Steroid Biochem Mol Biol. 2013 Jul;136:131-8
pubmed: 23165145
J Invest Dermatol. 1997 Mar;108(3):302-6
pubmed: 9036929
Cancer Prev Res (Phila). 2018 May;11(5):265-278
pubmed: 29437671
J Food Sci. 2009 Mar;74(2):H47-51
pubmed: 19323750
Clin Exp Dermatol. 2013 Mar;38(2):185-8
pubmed: 23397947
Crit Care Med. 2010 Aug;38(8):1685-94
pubmed: 20562702
J Immunol. 1983 Apr;130(4):1586-91
pubmed: 6187815
Cancer Epidemiol Biomarkers Prev. 1997 Nov;6(11):957-61
pubmed: 9367070
J Invest Dermatol. 2007 Mar;127(3):698-706
pubmed: 17008880
J Immunol. 1998 Apr 15;160(8):3783-9
pubmed: 9558081
Nat Cell Biol. 2002 Jan;4(1):26-31
pubmed: 11780128
J Cosmet Dermatol. 2008 Dec;7(4):290-7
pubmed: 19146606
J Invest Dermatol. 2021 Jan;141(1):11-14
pubmed: 33342506
J Am Acad Dermatol. 2021 Jul;85(1):56-61
pubmed: 33610593
Carcinogenesis. 1999 Oct;20(10):1939-44
pubmed: 10506108
Am J Kidney Dis. 2005 Mar;45(3):531-9
pubmed: 15754275
PLoS One. 2020 Apr 30;15(4):e0232009
pubmed: 32353018
JAMA Dermatol. 2019 Nov 1;155(11):1260-1268
pubmed: 31365038
J Biol Chem. 1958 Aug;233(2):493-500
pubmed: 13563527
Photodermatol Photoimmunol Photomed. 1996 Apr;12(2):45-56
pubmed: 8897589
Photochem Photobiol. 2008 Mar-Apr;84(2):350-5
pubmed: 18179621
Antioxidants (Basel). 2019 Jul 31;8(8):
pubmed: 31370257
Br J Dermatol. 2009 Dec;161(6):1357-64
pubmed: 19804594
Photochem Photobiol. 2008 Mar-Apr;84(2):477-83
pubmed: 18266821
Photochem Photobiol. 2019 Jul;95(4):1029-1034
pubmed: 30663066
Ann Dermatol. 2016 Jun;28(3):304-13
pubmed: 27274628
Biochem Biophys Res Commun. 2003 Jun 6;305(3):761-70
pubmed: 12763058
Trends Mol Med. 2003 Apr;9(4):169-76
pubmed: 12727143
Mol Cell. 2003 Oct;12(4):829-39
pubmed: 14580335
J Natl Cancer Inst. 2010 Dec 15;102(24):1835-44
pubmed: 21115882
Trends Biochem Sci. 2007 Jan;32(1):12-9
pubmed: 17161604
Photochem Photobiol. 2008 Mar-Apr;84(2):522-7
pubmed: 18266822
Am J Clin Dermatol. 2010;11(1):45-50
pubmed: 20000874
J Am Acad Dermatol. 2004 Jan;50(1):41-9
pubmed: 14699363
Neoplasia. 2003 Nov-Dec;5(6):555-65
pubmed: 14965448
Biomark Res. 2020 Sep 7;8:39
pubmed: 32944243
Carcinogenesis. 2013 May;34(5):1144-9
pubmed: 23349012
Free Radic Biol Med. 2015 Aug;85:1-11
pubmed: 25845487
J Am Acad Dermatol. 2017 Jul;77(1):33-41.e1
pubmed: 28341348
J Am Acad Dermatol. 2018 Feb;78(2):414-416
pubmed: 29332714
Cancer Prev Res (Phila). 2017 Oct;10(10):598-606
pubmed: 28912118
Arch Dermatol. 1994 Oct;130(10):1257-61
pubmed: 7944506
Nature. 2011 Aug 21;477(7364):349-53
pubmed: 21857681
J Agric Food Chem. 2003 May 7;51(10):2866-87
pubmed: 12720366
Am J Clin Nutr. 2004 Nov;80(5):1270-5
pubmed: 15531675
Nature. 1991 Jan 31;349(6308):431-4
pubmed: 1992344
J Invest Dermatol. 1995 Apr;104(4):484-8
pubmed: 7706763
Nutr Cancer. 1999;34(1):36-41
pubmed: 10453439
Cancer Prev Res (Phila). 2011 Sep;4(9):1485-94
pubmed: 21733837
Cancer Lett. 2003 Jul 10;196(2):169-77
pubmed: 12860275
J Dermatol Sci. 2018 Jan;89(1):3-10
pubmed: 29111181
Toxicol Res. 2010 Mar;26(1):61-6
pubmed: 24278507
Biochem Pharmacol. 1996 Jun 28;51(12):1727-38
pubmed: 8687488
Nutr J. 2014 Jun 27;13:66
pubmed: 24970388
J Am Acad Dermatol. 2003 Oct;49(4):644-50
pubmed: 14512910
Eur J Pharmacol. 2019 Jun 15;853:256-263
pubmed: 30930249
Br J Dermatol. 2012 May;166(5):1069-80
pubmed: 22251204
J Invest Dermatol. 2021 Jan;141(1):132-141.e3
pubmed: 32569596
Cancer Epidemiol Biomarkers Prev. 1998 Apr;7(4):351-4
pubmed: 9568793
J Invest Dermatol. 1996 Jun;106(6):1182-6
pubmed: 8752654
J Invest Dermatol. 2021 Jan;141(1):152-163
pubmed: 32619504
Mol Cancer Res. 2005 Feb;3(2):90-9
pubmed: 15755875
Future Oncol. 2010 Mar;6(3):457-70
pubmed: 20222801
J Biol Chem. 2015 Nov 6;290(45):27158-27167
pubmed: 26408197
J Invest Dermatol. 2000 May;114(5):923-7
pubmed: 10771472
Photochem Photobiol. 2012 Sep-Oct;88(5):1126-34
pubmed: 22181855
J Am Chem Soc. 2011 May 11;133(18):7016-24
pubmed: 21506564
Am J Clin Nutr. 2015 Sep;102(3):608-15
pubmed: 26178731
Cell. 2004 May 14;117(4):495-502
pubmed: 15137942
J Immunol. 2008 Jul 1;181(1):217-24
pubmed: 18566387
J Invest Dermatol. 2008 Oct;128(10):2508-17
pubmed: 18509362
J Cell Mol Med. 2009 Sep;13(9B):3632-43
pubmed: 18681908
Arch Biochem Biophys. 1992 Aug 1;296(2):575-82
pubmed: 1632644
Physiol Rev. 1999 Oct;79(4):1193-226
pubmed: 10508233
J Immunol. 1992 Dec 15;149(12):3865-71
pubmed: 1460278
Dermatology. 1999;198(1):52-5
pubmed: 10026402
Br J Dermatol. 1998 Aug;139(2):332-9
pubmed: 9767255
Arch Dermatol Res. 1981;270(4):453-62
pubmed: 7283473
Mol Endocrinol. 2012 Apr;26(4):574-82
pubmed: 22322599
Clin Cancer Res. 2013 Nov 1;19(21):5849-55
pubmed: 24100626
J Immunol. 2002 Jun 15;168(12):6128-35
pubmed: 12055224
Environ Mol Mutagen. 2017 Jun;58(5):235-263
pubmed: 28485537
Pharm Res. 2010 Jun;27(6):1092-102
pubmed: 20143255
Front Pharmacol. 2020 Jan 28;10:1614
pubmed: 32116665
J Invest Dermatol. 1981 Mar;76(3):202-10
pubmed: 6453905
PLoS One. 2013 May 14;8(5):e63809
pubmed: 23691100
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7532-6
pubmed: 6961430
J Invest Dermatol. 2012 May;132(5):1497-500
pubmed: 22297641
Am J Clin Nutr. 1991 Dec;54(6 Suppl):1252S-1255S
pubmed: 1962578
Sci STKE. 2003 Jan 28;2003(167):RE2
pubmed: 12554854
Br J Dermatol. 2017 Feb;176(2):551-552
pubmed: 27880000
Mycoses. 2010 May;53(3):204-7
pubmed: 19761490
Cancer Prev Res (Phila). 2010 Dec;3(12):1621-9
pubmed: 20947490
Cancer Causes Control. 2002 Apr;13(3):221-30
pubmed: 12020103
J Photochem Photobiol B. 2005 Feb 1;78(2):141-8
pubmed: 15664501
Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1658-63
pubmed: 23319653
Arch Dermatol Res. 2004 Feb;295(8-9):307-11
pubmed: 14648074
Mol Pharmacol. 2011 Jan;79(1):34-41
pubmed: 20881006
J Invest Dermatol. 2005 Oct;125(4):826-32
pubmed: 16185284
BMJ. 2011 Jan 11;342:c7086
pubmed: 21224324
Photochem Photobiol. 2012 Sep-Oct;88(5):1149-56
pubmed: 22540890
Acta Derm Venereol. 2000 Jan-Feb;80(1):66-7
pubmed: 10721847
J Invest Dermatol. 2002 Apr;118(4):565-72
pubmed: 11918700
J Invest Dermatol. 2008 Feb;128(2):447-54
pubmed: 17882270
Toxicol Appl Pharmacol. 2015 Apr 1;284(1):92-99
pubmed: 25680589
Exp Dermatol. 2007 Oct;16(10):823-9
pubmed: 17845214
Carcinogenesis. 2009 Jan;30(1):101-5
pubmed: 19028705
Avicenna J Phytomed. 2020 May-Jun;10(3):287-296
pubmed: 32523883
Nutrients. 2014 Aug 11;6(8):3202-13
pubmed: 25116848
Toxicol In Vitro. 2006 Jun;20(4):464-71
pubmed: 16263237
J Dairy Sci. 1989 Sep;72(9):2257-65
pubmed: 2592640
Mol Cell. 2005 Apr 29;18(3):283-93
pubmed: 15866171
Oxid Med Cell Longev. 2019 Jan 6;2019:9529676
pubmed: 30723535
J Invest Dermatol. 2005 Feb;124(2):304-7
pubmed: 15675947
Cancer Cell. 2014 Mar 17;25(3):304-17
pubmed: 24651012