Is There
Drake equation
circulating tumor cells
metastasis
metastatic process
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
22 Jul 2021
22 Jul 2021
Historique:
received:
06
06
2021
revised:
17
07
2021
accepted:
19
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
The majority of cancer-related deaths are the result of metastases (i.e., dissemination and establishment of tumor cells at distant sites from the origin), which develop through a multi-step process classically termed the metastatic cascade. The respective contributions of each step to the metastatic process are well described but are also currently not completely understood. Is there, for example, a critical phase that disproportionately affects the probability of the development of metastases in individual patients? Here, we address this question using a modified Drake equation, initially formulated by the astrophysicist Frank Drake to estimate the probability of the emergence of intelligent civilizations in the Milky Way. Using simulations based on realistic parameter values obtained from the literature for breast cancer, we examine, under the linear progression hypothesis, the contribution of each component of the metastatic cascade. Simulations demonstrate that the most critical parameter governing the formation of clinical metastases is the survival duration of circulating tumor cells (CTCs).
Identifiants
pubmed: 34359593
pii: cancers13153693
doi: 10.3390/cancers13153693
pmc: PMC8345184
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Marie Skłodowska-Curie
ID : 765492
Organisme : ERA-NET EU/TRANSCAN
ID : 2 JTC 2016 PROLIPSY
Organisme : SIRIC Montpellier Cancer Grant
ID : INCa_Inserm_DGOS_12553
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